The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia

Coagulation and sepsis

(2017) Marcel Levi et al.   THROMBOSIS RESEARCH

Thrombin Augments LPS-Induced Human Endometrial Endothelial Cell Inflammation via PAR1 Activation

(2016) Mohak V. Mhatre et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Cross Talk Pathways Between Coagulation and Inflammation

(2016) Jonathan H. Foley et al.   CIRCULATION RESEARCH

Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo

(2016) Michael C. W. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR3 or TLR4 Activation Enhances Mesenchymal Stromal Cell-Mediated Treg Induction via Notch Signaling

(2016) Iran Rashedi et al.   STEM CELLS

TLR4 Activation Promotes Bone Marrow MSC Proliferation and Osteogenic Differentiation via Wnt3a and Wnt5a Signaling

(2016) Xiaoqing He et al.   PLoS One

Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review

(2016) Lauralyn A. McIntyre et al.   PLoS One

Antibacterial effect of mesenchymal stem cells againstEscherichia coliis mediated by secretion of beta- defensin- 2 via toll- like receptor 4 signalling

(2015) Dong Kyung Sung et al.   CELLULAR MICROBIOLOGY

The role of toll-like and protease-activated receptors in the expression of cytokines by gingival fibroblasts stimulated with the periodontal pathogen Porphyromonas gingivalis

(2015) Eleonor Palm et al.   CYTOKINE

LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b

(2015) Dongdong Ti et al.   Journal of Translational Medicine

Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat

(2015) J. Devaney et al.   THORAX

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome

(2015) Oscar E. Simonson et al.   Stem Cells Translational Medicine

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial

(2015) Jennifer G Wilson et al.   Lancet Respiratory Medicine

Multiple roles of the coagulation protease cascade during virus infection

(2014) S. Antoniak et al.   BLOOD

Thrombin promotes fibronectin secretion by bone marrow mesenchymal stem cells via the protease-activated receptor mediated signalling pathways

(2014) Jin Chen et al.   Stem Cell Research & Therapy

Therapeutic Effects of Human Mesenchymal Stem Cells inEx VivoHuman Lungs Injured with Live Bacteria

(2013) Jae W. Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism

(2013) Kohei Tatsumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact

(2013) Frank Gieseler et al.   Cell Communication and Signaling

CD105 (Endoglin)-Negative Murine Mesenchymal Stromal Cells Define a New Multipotent Subpopulation with Distinct Differentiation and Immunomodulatory Capacities

(2013) Per Anderson et al.   PLoS One

TLR Ligands Stimulation Protects MSC from NK Killing

(2013) Massimo Giuliani et al.   STEM CELLS

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR2) is involved in vascular function

(2012) M Bucci et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mesenchymal stem cells enhance survival and bacterial clearance in murineEscherichia colipneumonia

(2012) Naveen Gupta et al.   THORAX

CD105 Protein Depletion Enhances Human Adipose-derived Stromal Cell Osteogenesis through Reduction of Transforming Growth Factor β1 (TGF-β1) Signaling

(2011) Benjamin Levi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate immunity and coagulation

(2011) C. T. ESMON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Toll-Like Receptor-3-Activated Human Mesenchymal Stromal Cells Significantly Prolong the Survival and Function of Neutrophils

(2011) Marco A. Cassatella et al.   STEM CELLS

Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis

(2010) Shirley H. J. Mei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammation and coagulation

(2010) Marcel Levi et al.   CRITICAL CARE MEDICINE

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype

(2010) Ruth S. Waterman et al.   PLoS One

Antibacterial Effect of Human Mesenchymal Stem Cells Is Mediated in Part from Secretion of the Antimicrobial Peptide LL-37

(2010) Anna Krasnodembskaya et al.   STEM CELLS

Cytokine Modulation of TLR Expression and Activation in Mesenchymal Stromal Cells Leads to a Proinflammatory Phenotype

(2009) R. Romieu-Mourez et al.   JOURNAL OF IMMUNOLOGY

Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo

(2009) Q M Nhu et al.   Mucosal Immunology

Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung

(2009) J. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Metalloproteinase 1 Is Necessary for the Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells Toward Human Glioma

(2009) Ivy A. W. Ho et al.   STEM CELLS

Analysis of Proteinase-activated Receptor 2 and TLR4 Signal Transduction

(2008) Prasad Rallabhandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE

Toll-Like Receptors 3 and 4 Are Expressed by Human Bone Marrow-Derived Mesenchymal Stem Cells and Can Inhibit Their T-Cell Modulatory Activity by Impairing Notch Signaling

(2007) Francesco Liotta et al.   STEM CELLS