4.8 Article

Biosafe, Eco-Friendly Levan Polysaccharide toward Transient Electronics

Journal

SMALL
Volume 14, Issue 32, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201801332

Keywords

biocompatible; biodegradable; implantable electronics; polysaccharide; transient electronics

Funding

  1. Basic Science Research Program through National Research Foundation of Korea - Ministry of Science, ICT, and Future Planning [NRF-2017R1D1A1B03033089, NRF-2017R1A5A1070259]
  2. KU-KIST Graduate School of Converging Science and Technology Program, KU Future Research Grant
  3. Basic Science Research Program through National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [NRF-2015R1C1A1A02037560, NRF-2017R1E1A1A01075027]

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New options in the material context of transient electronics are essential to create or expand potential applications and to progress in the face of technological challenges. A soft, transparent, and cost-effective polymer of levan polysaccharide that is capable of complete, programmable dissolution is described when immersed in water and implanted in an animal model. The results include chemical analysis, the kinetics of hydrolysis, and adjustable dissolution rates of levan, and a simple theoretical model of reactive diffusion governed by temperature. In vivo experiments of the levan represent nontoxicity and biocompatibility without any adverse reactions. On-demand, selective control of dissolution behaviors with an animal model demonstrates an effective triggering strategy to program the system's lifetime, providing the possibility of potential applications in envisioned areas such as bioresorbable electronic implants and drug release systems.

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