Article
Infectious Diseases
Chatte Adawaye, Adda Oumar Souleymane, Abdelrazzack Adoum Fouda, Oumaima Djarma, Amandine Cournil, Edouard Tuaillon, J. D. Franck Mennechet
Summary: This study in the Republic of Chad reveals a high prevalence of syphilis infection among people living with HIV, with significant decline in syphilis antibodies after treatment. Systematic screening for syphilis should be considered in this population.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Yoshiki Hase, Kamar E. Ameen-Ali, Rachel Waller, Julie E. Simpson, Charlotte Stafford, Ayushi Mahesh, Lucy Ryan, Lucy Pickering, Caroline Bodman, Mai Hase, Delphine Boche, Karen Horsburgh, Stephen B. Wharton, Raj N. Kalaria
Summary: This study assessed the status of perivascular microglia in stroke survivors who develop dementia and found that dementia patients accumulate more activated perivascular CD68+ microglia in white matter, rather than TREM2+ cells. This suggests that CD68+ cells play a differential role in perivascular inflammation within the gliovascular unit of the deep white matter.
Article
Clinical Neurology
Rebecca F. Gottesman, Sudha Seshadri
Summary: This article summarizes the relationship between traditional cardiovascular risk factors and stroke, while also exploring their impact on brain health. It emphasizes the importance of genes and biomarkers associated with Alzheimer's disease, as well as the influence of social determinants of health on brain health outcomes.
Article
Clinical Neurology
Christina Mayer, Marcel S. Woo, Thomas Theo Brehm, Andreas Heyer, Marlene Fischer, Felix Fischbach, Lukas C. Bal, Marylyn M. Addo, Stefan Kluge, Goetz Thomalla, Nils Schweingruber, Julian Schulze zur Wiesch
Summary: This study aimed to investigate whether pre-existing neurological conditions, such as dementia and a history of cerebrovascular disease, increase the risk of severe outcomes in patients hospitalized with SARS-CoV-2 infection in 2022. The analysis revealed that pre-existing cerebrovascular disease and all-cause dementia did not increase the risk of mortality or ICU admission. However, patients with pre-existing cerebrovascular disease and myocardial infarction in their medical history may be more susceptible to vascular complications following SARS-CoV-2 infection with the Omicron variant.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Stina Aam, Mari Nordbo Gynnild, Ragnhild Munthe-Kaas, Ingvild Saltvedt, Stian Lydersen, Anne-Brita Knapskog, Hege Ihle-Hansen, Hanne Ellekjaer, Rannveig Sakshaug Eldholm, Brynjar Fure
Summary: Post-stroke cognitive impairment (PSCI) is influenced by vascular risk factors, with atrial fibrillation, coronary heart disease, and previous stroke leading to more severe cognitive deficits. However, some cognitive domains show improvement from 3 to 18 months in patients without specific risk factors. Further research on interventions targeting vascular risk factors is needed to prevent PSCI.
FRONTIERS IN NEUROLOGY
(2021)
Editorial Material
Clinical Neurology
Mayowa O. Owolabi
Summary: Stroke, dementia, and ischemic heart disease are the leading causes of death and disability worldwide, but they share similar risk factors that can be targeted for prevention. In Norway, these diseases have seen significant decline in incidence rates due to equitable income, universal health coverage, and a responsive health system. It is important for all countries to develop national strategies and allocate resources to combat these diseases within the context of sustainable development goals.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Vladimir Hachinski
Summary: The pandemic is driving changes in neurology, with the rise of long COVID and neurologic diseases. Advancements in technology, artificial intelligence, and virtual worlds are also shaping a new era in brain science and creating new roles for neurologists. By focusing on brain health as a unifying theme, neurologists have the opportunity to lead in integrating and applying brain knowledge, serving as advocates, healers, and guardians of the brain.
Article
Chemistry, Analytical
Sugondo Hadiyoso, Hasballah Zakaria, Paulus Anam Ong, Tati Latifah Erawati Rajab
Summary: Dementia refers to a set of symptoms that affect cognitive functions of the brain, including memory, thinking, behavior, and language. Vascular dementia is one of the most common types of dementia, often associated with cerebrovascular disease like stroke. This study discusses the feasibility of using quantitative EEG methods to identify vascular dementia in post-stroke patients, providing additional diagnostic criteria.
Article
Neurosciences
Ren Ding, Yoshiki Hase, Matthew Burke, Vincent Foster, William Stevenson, Tuomo Polvikoski, Raj N. Kalaria
Summary: The study found a 45% decrease in the number of pericytes in the frontal cortical capillaries in older controls compared to normal young controls, while the numbers of pericytes were relatively preserved or increased in PSD, AD and Mixed dementia groups. This suggests aging-related loss but mostly preserved pericytes in the frontal cortex of vascular and AD dementias.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Clinical Neurology
Joanna M. Wardlaw, Fergus Doubal, Rosalind Brown, Ellen Backhouse, Lisa Woodhouse, Philip Bath, Terence J. Quinn, Thompson Robinson, Hugh S. Markus, Richard McManus, John T. O'Brien, David J. Werring, Nikola Sprigg, Adrian Parry-Jones, Rhian M. Touyz, Steven Williams, Yee-Haur Mah, Hedley Emsley
Summary: The R4VaD study aims to recruit a wide range of post-stroke patients in the UK to determine rates and risk factors for cognitive impairments after stroke, assess potential mechanisms and improve prediction models.
EUROPEAN STROKE JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Dominik Michalski, Willi Reimann, Emma Spielvogel, Bianca Mages, Bernd Biedermann, Henryk Barthel, Bjorn Nitzsche, Stefan Schob, Wolfgang Hartig
Summary: This study provides the first spatio-temporal characterization of surfactant protein-G (SP-G) and neurovascular unit (NVU) elements after experimental stroke. The results show a decrease in SP-G signals in ischemic areas and inverse immunosignals of SP-G and vascular elements. In addition, morphological alterations or changed intensities were observed in signals originating from neurons, glial elements, and extracellular matrix.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Satoshi Hosoki, Tomotaka Tanaka, Masafumi Ihara
Summary: Reliable blood biomarkers are crucial in the early diagnosis and therapeutic intervention of vascular dementia (VaD) and acute ischemic stroke (AIS). Both VaD and AIS share similar pathological conditions, and superior VaD blood biomarkers may be found among AIS blood biomarkers. Noncoding RNAs such as microRNA and long noncoding RNA, which can be analyzed using a single drop of blood, are particularly reliable VaD markers that reflect brain tissue damage.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Behavioral Sciences
Tiantian Zhu, Moli Zhu, Yue Qiu, Zeqing Wu, Ning Huang, Guangrui Wan, Jian Xu, Ping Song, Shuangxi Wang, Yaling Yin, Peng Li
Summary: The study demonstrates that Pur has therapeutic potential for VD induced by BCCAO, potentially improving cognitive deficits and vascular injury by reducing oxidative stress. This improvement may be mediated through the ROS-dependent TRPM2/NMDAR pathway.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Minwoo Lee, Jae-Sung Lim, Yerim Kim, Soo Hyun Park, Sang-Hwa Lee, Chulho Kim, Byung-Chul Lee, Kyung-Ho Yu, Jae-Jun Lee, Mi Sun Oh
Summary: The ApoB/ApoA-I ratio in the acute stage of stroke independently predicts the development of post-stroke cognitive impairment (PSCI) at 3-6 months after stroke due to large artery atherosclerosis. Specifically, a high ApoB/ApoA-I ratio is associated with dysfunction in the frontal domain.
Review
Cell Biology
Yi Yang, Xinyuan Zhao, Zirui Zhu, Lihui Zhang
Summary: This article reviews the role of microglia in regulating neuroinflammation in the pathogenesis of vascular dementia (VaD), which is the second most common form of age-related dementia. The commonly used animal and cell models for understanding the disease pathogenesis are summarized. The mechanisms by which microglia contribute to VaD are multifactorial, and this article specifically focuses on their chemotaxis, secretory property, phagocytosis, and crosstalk with other neurovascular unit cells.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Mohammed Hakmi, E. L. Mehdi Bouricha, Jihane Akachar, Badreddine Lmimouni, Jaouad El Harti, Lahcen Belyamani, Azeddine Ibrahimi
Summary: The rapid spread and increasing number of cases of the novel coronavirus requires immediate development of effective therapies, vaccines, and accurate diagnosis tools. This study used computational simulations to explore small-molecule inhibitors that could disrupt the virus's entry into host cells. Critical target regions were identified and promising candidates with favorable binding affinities were found.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
El Mehdi Bouricha, Mohammed Hakmi, Jihane Akachar, Fouad Zouaidia, Azeddine Ibrahimi
Summary: This study identified three potential compounds that may inhibit the ERα signaling pathway and could be used to treat hormone therapy-resistant breast cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Walid Guerrab, Meryem El Jemli, Jihane Akachar, Gunes Demirtas, Joel T. Mague, Jamal Taoufik, Azeddine Ibrahimi, M'Hammed Ansar, Katim Alaoui, Youssef Ramli
Summary: The study reports the synthesis and molecular characterization of a novel phenytoin derivative, involving DFT calculation, crystal structure analysis with Hirshfeld surface, psychotropic activity evaluation, and molecular modeling for potential neurotherapeutic drug development.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Health Care Sciences & Services
Sarah Elhourch, Housna Arrouchi, Nour Mekkaoui, Younes Allou, Fatima Ghrifi, Loubna Allam, Naima Elhafidi, Lahcen Belyamani, Azeddine Ibrahimi, Naoual Elomri, Rachid Eljaoudi
Summary: The study revealed a significant association of TCF7L2 gene polymorphisms (rs7903146 (C/T) and rs12255372 (G/T)) with a higher risk of developing type 2 diabetes mellitus in the Moroccan population, with the T allele being associated with an increased risk of diabetes. There were no significant differences in anthropometric and metabolic parameters between different genotypes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Chemistry, Physical
Karim Chkirate, Jihane Akachar, Brahim Hni, Tuncer Hokelek, El Hassane Anouar, Ahmed Talbaoui, Joel T. Mague, Nada Kheira Sebbar, Azeddine Ibrahimi, El Mokhtar Essassi
Summary: Two novel 1,5-benzodiazepin-2-one derivatives were synthesized and characterized, with compound 3 showing remarkable activity against Streptococcus faecalis and compound 5 exhibiting significant antibacterial activity against Escherichia coli, Staphylococcus aureus, and Streptococcus faecalis. Molecular docking was performed to rationalize the mode of action and binding affinity of the compounds at the active site of the bacteria.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Multidisciplinary Sciences
Jihane Akachar, Catherine Etchebest, Rachid El Jaoudi, Azeddine Ibrahimi
Summary: In this study, molecular dynamics simulations were used to investigate the impact of mutations and conformational changes in CD36 protein on its functionality and stability. The Lys164 residue was found to play an important role in fatty acid uptake and provided a structural basis for the dissociation of palmitic acid. Additionally, simulations revealed two fatty acid holes in the CD36 cavity structure, which were crucial for CD36 structure stabilization.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Abdelmounim Essabbar, Souad Kartti, Tarek Alouane, Mohammed Hakmi, Lahcen Belyamani, Azeddine Ibrahimi
Summary: The paper discusses the International Database of SARS-CoV-2 Variations (IDbSV) as a comprehensive tool for understanding genetic variations and variants of the virus. The database provides user-friendly interactive data visualizations for the scientific and public health communities. IDbSV offers access to over 60,000 annotated variations, making it the largest repository for SARS-CoV-2 variations and genome analysis.
FRONTIERS IN MEDICINE
(2021)
Review
Education & Educational Research
Youness Touissi, Ghita Hjiej, Abderrazak Hajjioui, Azeddine Ibrahimi, Maryam Fourtassi
Summary: The study examines the effects of student-generated multiple-choice questions on medical learning, finding that it has a positive impact on students' perception and performance. Despite some concerns, writing multiple-choice questions as a learning method is proven to be effective.
MEDICAL EDUCATION ONLINE
(2022)
Article
Biochemistry & Molecular Biology
Walid Guerrab, Jihane Akachar, Meryem El Jemli, Abdul-Malik Abudunia, Rachida Ouaabou, Katim Alaoui, Azeddine Ibrahimi, Youssef Ramli
Summary: Hydantoins are an important class of compounds with remarkable biological and pharmacological properties. This study successfully synthesized hydantoin derivatives and evaluated their cytotoxic activity. The synthesized compounds showed significant inhibitory effects on cell lines, suggesting their potential as anticancer drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Physical
El Mehdi Bouricha, Mohammed Hakmi, Souad Kartti, Fouad Zouaidia, Azeddine Ibrahimi
Summary: Small molecule antagonists that bind to the ligand-binding domain of estrogen receptor alpha (ERa) are effective in treating ER alpha-positive breast cancer patients. However, acquired treatment resistance is observed in the presence of somatic mutations in the ligand-binding domain of ER alpha. This study compares the mechanism of resistance to the antagonist 4-hydroxy tamoxifen (4-OHT) in wild-type and mutant ERa, and suggests that the Y537S mutation stabilizes Helix 12 and enhances the agonistic conformation of the receptor.
MOLECULAR SIMULATION
(2022)
Article
Virology
Amal Zouaki, Hakima Kabbaj, Ghizlane El Amin, Mouna Ouadghiri, Bouchra Belefquih, Azeddine Ibrahimi, Myriam Seffar
Summary: This study evaluated the performance of the new Moroccan SARS-CoV-2 detection kit, MAScIR SARS-CoV-2 M 2.0. The results demonstrated that the kit met the requirements for method verification/validation and successfully detected the Alpha, Delta, and Omicron variants.
ADVANCES IN VIROLOGY
(2023)
Article
Microbiology
Tarik Aanniz, Mouna Ouadghiri, Mohammed Amine Bendahou, Mohammed Walid Chemao-Elfihri, Mohamed Chenaoui, Hanae Dakka, Afaf Allaoui, Otmane Touzani, Amina Benaouda, Bouchra Belefquih, Saaid Amzazi, Lahcen Belyamani, Azeddine Ibrahimi
Summary: This report presents the nearly complete genome sequence and genetic variations of SARS-CoV-2 from a clinical sample collected in Morocco, including a recently described deletion and substitution, which are of clinical and research significance.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Review
Chemistry, Applied
Omar El Blidi, Nasreddine El Omari, Abdelaali Balahbib, Rokia Ghchime, Naoual El Menyiy, Azeddine Ibrahimi, Khalid Ben Kaddour, Abdelhakim Bouyahya, Omar Chokairi, Malika Barkiyou
Summary: Developing a standard extraction method for all types of collagen from different tissues is challenging due to their extreme diversity. Different methods have their pros and cons, and some have been optimized for easier extraction. Collagen plays a significant role in biomedical applications.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2021)
Article
Transplantation
Bouchra Rezzouk, Tarik Bouattar, Bouchra Belkadi, Rachid Razine, Rabia Bayahia, Naima Ouzeddoun, Loubna Benamar, Hakima Rhou, Najat Bouihat, Azeddine Ibrahimi, Myriam Seffar, Hakima Kabbaj
Summary: This study found that patients with high-level CMV DNAemia were at increased risk of disease progression and acute rejection. Monitoring viral load during the first year post-transplantation is essential to support current preventive strategies.
TRANSPLANT RESEARCH AND RISK MANAGEMENT
(2021)
Article
Microbiology
M. Laamarti, N. El Mrimar, T. Alouane, S. Kartti, E. Belouad, F. Bssaibis, A. Zegmout, R. El Jaoudi, A. Maleb, A. Abid, N. El Hajjami, A. Lemnouer, S. Siah, L. Belyamani, M. Elouennass, A. Ibrahimi
Summary: This study presents draft genome sequences of two Mycobacterium tuberculosis strains isolated from patients with pulmonary tuberculosis in Morocco, aiming to identify variants associated with drug resistance.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
