Article
Nutrition & Dietetics
Patricia Budihartanti Liman, Karina Shasri Anastasya, Nabila Maudy Salma, Yenny Yenny, Meutia Atika Faradilla
Summary: The aim of this study was to analyze scientific articles on advanced glycation end products (AGEs) and obesity using bibliometric methods. The results showed an increase in studies on processed foods and obesity, with the United States making the largest contribution in this field. Open access journals had higher citation numbers and younger publication years compared to closed access journals.
Article
Nutrition & Dietetics
Marco Mouanness, Zaher Merhi
Summary: Advanced glycation end products (AGEs), formed by the reaction between protein and reducing sugars, can impact reproductive health and fertility through inducing inflammation and oxidative stress. This review summarizes the recent data on the pathogenesis of dietary AGEs and their potential impact on female reproductive health and offspring reproduction.
Review
Nutrition & Dietetics
Marco Mouanness, Henry Nava, Christelle Dagher, Zaher Merhi
Summary: Recent studies have found that dietary advanced glycation end products (AGEs) play a significant role in reproductive and metabolic dysfunctions associated with polycystic ovary syndrome (PCOS). AGEs are reactive molecules formed by the non-enzymatic glycation process between reducing sugars and proteins, lipids, or nucleic acids. This review discusses the involvement of AGEs in key elements of the PCOS phenotype and pathophysiology and suggests targeting AGEs as a potential novel approach to treating PCOS symptoms.
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Review
Cardiac & Cardiovascular Systems
Lakshmi Arivazhagan, Raquel Lopez-Diez, Alexander Shekhtman, Ravichandran Ramasamy, Ann Marie Schmidt
Summary: Obesity and non-alcoholic fatty liver disease (NAFLD) are increasing globally. Consumption of high fat/high sugar diet leads to biochemical and molecular reactions that contribute to atherosclerosis and cardiovascular disease. RAGE/DIAPH1 signaling pathway plays a role in foam cell formation, cholesterol metabolism, and exacerbation of metabolic disorders and cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Nutrition & Dietetics
Melpomeni Peppa, Ioanna Mavroeidi
Summary: Research indicates that dietary advanced glycation end products play a significant role in health and disease, contributing to the pathogenesis of various diseases and their complications in animal models. They are also involved in changes related to the aging process.
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Endocrinology & Metabolism
Sara Csiha, Istvan Molnar, Sandor Halmi, David Hutkai, Hajnalka Lorincz, Sandor Somodi, Monika Katko, Mariann Harangi, Gyorgy Paragh, Endre V. Nagy, Eszter Berta, Miklos Bodor
Summary: The levels of advanced glycation end products (AGEs) in the serum of patients with Hashimoto thyroiditis (HT) are lower, and soluble RAGE (sRAGE) can reduce the interaction between AGEs and their receptor in a competitive manner, which is beneficial for thyroid function balance in patients. Further research is needed to confirm these results.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Biochemistry & Molecular Biology
Xiao Yang, Cong-Jin Liu, Zhen-Zhen Wang, Dong Ding, Jing-Wen Shi, Xin-Tong Wu, Lian-Wen Sun, Yu-Bo Fan
Summary: AGEs negatively impact the mechanosensitivity of osteocytes, affecting the bone remodeling process. This study provides a new perspective on exploring the mechanism of osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Gopal Ammanath, Carla Giorgia Delachi, Soner Karabacak, Yusuf Ali, Bernhard O. Boehm, Umit Hakan Yildiz, Palaniappan Alagappan, Bo Liedberg
Summary: A simple method for colorimetric and fluorometric profiling of AGEs was reported in this study, utilizing changes in optical properties of PTs and Apts to estimate the concentrations of AGEs in plasma, and achieving distinct profiling of different AGEs through PCA analysis. The approach allows for rapid analysis of spiked AGEs in plasma samples without the need for preanalytical processing and advanced instrumentation, facilitating on-site diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Obstetrics & Gynecology
Jennifer C. Hutchison, Jemma Evans, Tracey A. Edgell, Guiying Nie, David K. Gardner, Lois A. Salamonsen
Summary: The study found that obese infertile women have elevated levels of advanced glycation end-products (AGE) in their uterine environment. The detrimental effects of AGE on endometrial epithelial cells can be reduced with therapeutics and replicated in a more physiologically relevant primary model (organoids).
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Endocrinology & Metabolism
Xingyu Zhang, Xiaoyu Chen, Shengjie Li, Mengze Gao, Peipei Han, Liou Cao, Jing Gao, Qiongying Tao, Jiayi Zhai, Dongyu Liang, Li Qin, Qi Guo
Summary: This study found that elevated levels of AGEs are associated with sarcopenia, but not with presarcopenia. Osteoporosis plays a partial mediating role in the association between AGEs and sarcopenia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)