Article
Endocrinology & Metabolism
Xingyu Zhang, Xiaoyu Chen, Shengjie Li, Mengze Gao, Peipei Han, Liou Cao, Jing Gao, Qiongying Tao, Jiayi Zhai, Dongyu Liang, Li Qin, Qi Guo
Summary: This study found that elevated levels of AGEs are associated with sarcopenia, but not with presarcopenia. Osteoporosis plays a partial mediating role in the association between AGEs and sarcopenia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Endocrinology & Metabolism
Liu Gao, Chang Liu, Pan Hu, Na Wang, Xiaoxue Bao, Bin Wang, Ke Wang, Yukun Li, Peng Xue
Summary: The objective of this study was to analyze the quantitative association between advanced glycation end products (AGEs) and adjusted FRAX by rheumatoid arthritis (FRAX-RA) in postmenopausal type 2 diabetic (T2D) patients. The optimal cutoff value of AGEs was also explored, which was aimed at demonstrating the potential value of AGEs on evaluating osteoporotic fracture risk in postmenopausal T2D patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Article
Oncology
Weiwei Ge, Jian Jie, Jie Yao, Wei Li, Yahui Cheng, Wenjuan Lu
Summary: This study investigated the effect of AGEs on osteoblast function and the underlying mechanisms. The results showed that AGEs disrupted osteoblast function by inducing cell ferroptosis, contributing to osteoporosis (OP). AGEs and serum from OP patients inhibited cell proliferation, differentiation, and mineralization, while promoting apoptosis and ferroptosis. Serum from OP patients with type-2 diabetes mellitus (T2DM) had a stronger effect than that from OP patients with normal fasting blood glucose (FBG). However, the ferroptosis inhibitor, deferoxamine (DFO), reversed the effects induced by AGEs and serum from OP and T2DM patients on osteoblast cells.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Medicine, General & Internal
So Young Park, Kyoung Hee Choi, Ji Eun Jun, Ho Yeon Chung
Summary: Advanced glycation end products (AGEs) suppress the differentiation and function of osteoclasts and osteoblasts, potentially leading to decreased bone quality and turnover.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Article
Nutrition & Dietetics
Patricia Budihartanti Liman, Karina Shasri Anastasya, Nabila Maudy Salma, Yenny Yenny, Meutia Atika Faradilla
Summary: The aim of this study was to analyze scientific articles on advanced glycation end products (AGEs) and obesity using bibliometric methods. The results showed an increase in studies on processed foods and obesity, with the United States making the largest contribution in this field. Open access journals had higher citation numbers and younger publication years compared to closed access journals.
Article
Nanoscience & Nanotechnology
Gopal Ammanath, Carla Giorgia Delachi, Soner Karabacak, Yusuf Ali, Bernhard O. Boehm, Umit Hakan Yildiz, Palaniappan Alagappan, Bo Liedberg
Summary: A simple method for colorimetric and fluorometric profiling of AGEs was reported in this study, utilizing changes in optical properties of PTs and Apts to estimate the concentrations of AGEs in plasma, and achieving distinct profiling of different AGEs through PCA analysis. The approach allows for rapid analysis of spiked AGEs in plasma samples without the need for preanalytical processing and advanced instrumentation, facilitating on-site diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Cong-Jin Liu, Xiao Yang, Shou-Hui Wang, Xin-Tong Wu, Yan Mao, Jing-Wen Shi, Yu-Bo Fan, Lian-Wen Sun
Summary: Bone loss occurs in astronauts during long-term space flight, and this study investigated the improvement effects of blocking AGEs formation on microgravity-induced bone loss using the AGES formation inhibitor, irbesartan. Results showed that irbesartan significantly inhibited AGEs and 8-OHdG expression, improving bone quality and bone formation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Govigerel Bayarsaikhan, Delger Bayarsaikhan, Pyung Chun Oh, Woong Chol Kang, Bonghee Lee
Summary: Researchers investigated the utility of AGEs as prognostic biomarkers for AMI and found that CUPRAC-reactive AGEs exhibit various patterns of changes in serum samples of AMI patients.
Review
Nutrition & Dietetics
Kate Phuong-Nguyen, Bryony A. A. McNeill, Kathryn Aston-Mourney, Leni R. R. Rivera
Summary: Consuming a high-AGE diet can lead to changes in gastrointestinal structure, modifications in enteric neurons, and reshaping of the microbiota, resulting in poor health outcomes.
Article
Oncology
Ziling Mao, Jacqueline Roshelli Baker, Masayoshi Takeuchi, Hideyuki Hyogo, Anne Tjonneland, Anne Kirstine Eriksen, Gianluca Severi, Joseph Rothwell, Nasser Laouali, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Domenico Palli, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Jeroen W. G. Derksen, Inger T. Gram, Guri Skeie, Torkjel M. Sandanger, Jose Ramon Quiros, Marta Crous-Bou, Maria-Jose Sanchez, Pilar Amiano, Sandra M. Colorado-Yohar, Marcela Guevara, Sophia Harlid, Ingegerd Johansson, Aurora Perez-Cornago, Heinz Freisling, Marc Gunter, Elisabete Weiderpass, Alicia K. Heath, Elom Aglago, Mazda Jenab, Veronika Fedirko
Summary: Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) are associated with the development and progression of colorectal cancer due to their oxidative and inflammatory properties. This study found that circulating glycer-AGEs concentrations are positively associated with both colorectal cancer-specific and all-cause mortality. The association between glycer-AGEs and colorectal cancer-specific mortality is stronger in patients with distal colon cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Engineering, Biomedical
Enze Zhou, Huiwen Huang, Yanbin Zhao, Lizhen Wang, Yubo Fan
Summary: This study analyzed the biomechanical responses of the cervical spine to titanium mesh cages with different heights and trimmed angles using the finite element method. A rating scale was designed to assess the biomechanical performances and help surgeons determine the optimal combination of cage height and trimmed angle. The findings suggest that for single-level Anterior Cervical Corpectomy and Fusion at C5 segment, a cage with a height fitting the space between C4 and C6 and a trimmed angle 2 degrees lower than the sagittal angle of C4 inferior endplate would provide adequate biomechanical environment for the cervical spine.
CLINICAL BIOMECHANICS
(2022)
Review
Engineering, Multidisciplinary
Kun Li, Junwei Xu, Ping Li, Yubo Fan
Summary: Magnetic ordered materials based on MNPs have unique advantages in biomedical applications, and future research should focus on safety, functionality, and structural diversity for interdisciplinary studies.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Xianda Yang, Weirong Zhang, Jie Yao, Anqiang Sun, Yuanming Gao, Meng Guo, Yubo Fan
Summary: This study utilized finite element analysis to simulate the degradation process of poly (lactic-co-glycolic acid) stent, revealing that the fracture time of the stent was delayed by 63% in the surface degradation mode compared to bulk degradation. This indicates significant differences in mass loss rate and scaffolding period between surface degradation and bulk degradation.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Lurong Jia, Chunjuan Wang, Chao Wang, Jinlin Song, Yubo Fan
Summary: This study evaluated the biomechanical effects of various multi-layers of clear aligners on maxillary anterior teeth retraction, showing that increasing soft layer thickness led to decreased tooth displacement, periodontal ligament pressure, and stress. Additionally, higher soft/hard layers ratio resulted in decreased elastic strain of clear aligners. Multi-layer clear aligners were found to be more effective in tooth movement and stress distribution compared to single-layer clear aligners, especially when the soft layer to hard layer ratio exceeded 50%.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Ronghui Liu, Chang Jin, Lizhen Wang, Yisong Yang, Yubo Fan, Weidong Wang
Summary: The study developed a simulation using finite element analysis to evaluate the outcome of stent retriever thrombectomy for clots of different sizes and frictional properties. By characterizing the mechanical behavior of stent retrievers and clots, the simulation method offers a potential tool for optimizing device design and selecting surgical strategies.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Polymer Science
Lichuang Zhang, Xiali Guan, Xiongfu Xiao, Yixin Chai, Zhigang Chen, Gang Zhou, Yubo Fan
Summary: An injectable ferrimagnetic chitosan thermosensitive hydrogel was developed for precise and responsive controlled release of drugs in cancer treatment, showing synergistic effect and sustained treatment in tumor cells killing with good biocompatibility.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Xin-Tong Wu, Xiao Yang, Ran Tian, Ying-Hui Li, Chun-Yan Wang, Yu-Bo Fan, Lian-Wen Sun
Summary: Decades of spaceflight studies have shown that cells are capable of sensing and responding to microgravity in space through cytoskeletal reorganization. The disruption of cytoskeletal equilibrium by the shift from ground to space gravity leads to cellular changes in morphology, mechanical properties, extracellular matrix, and signaling pathways, ultimately affecting cell functionality in microgravity.
Article
Engineering, Biomedical
Hongyan Tang, Shuangshuang Li, Yuan Zhao, Cunli Liu, Xuenan Gu, Yubo Fan
Summary: This study investigates the use of poly(trimethylene carbonate) (PTMC) drug-eluting coatings on magnesium alloys for vascular stent application. The PTMC35 coating provides excellent corrosion resistance and drug release ability, effectively inhibiting cell proliferation.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Kun Li, Junwei Xu, Jingxi Wang, Xuenan Gu, Ping Li, Yubo Fan
Summary: In this study, oriented hydrogel film and chitosan hydrogel film with gradient nanofibrous structure and mechanical property were prepared using the stretching-drying method. These films show great potential in inducing cell migration, orientation, and differentiation.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Multidisciplinary
Meili Liu, Chongquan Huang, Junwei Xu, Zitong An, Xiaomeng Deng, Gang Zhou, Ping Li, Yubo Fan
Summary: This study demonstrated that magnetic materials can effectively promote neuronal growth under magnetic field loading. Fe3O4@PLGA RBC-like MPs, with a red blood cell-like shape, were constructed and shown to significantly increase cell viability and growth indices in primary cultured cortical neurons when combined with magnetic field loading. Additionally, the protective effect of these magnetic particles and magnetic field loading was demonstrated in mice sciatic nerve injury.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Zhuang Han, Lian-Wen Sun, Xin-Tong Wu, Xiao Yang, Yu-Bo Fan
Summary: This study investigates the time-dependent changes and structural characteristics of the membrane skeleton in osteocytes under vibration stimulation. Results show that the membrane skeleton is affected by vibrations and undergoes dynamic responses and structural changes. The vibration at 15Hz has the most destructive effect on the membrane skeleton, suggesting a natural frequency below 15Hz. Chaos phenomena occur in the membrane skeleton during vibration, and the presence of viscosity helps mitigate structural damage.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Xiaoling Jia, Chao Gao, Xia Wang, Lin-Hua Jiang, Yubo Fan
Summary: This study found that mechanical stretch had different effects on the expressions of BKCa and L-VDCC channels in rat uterine smooth muscle cells, with stretch down-regulating BKCa channel expression but upregulating L-VDCC channel expression.
JOURNAL OF MEMBRANE BIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Xinpeng Wang, Hongzhang Wang, Kang Sun, Wanjun Li, Xuelin Wang, Xuanqi Chen, Liang Hu, Yubo Fan
Summary: This study presents a reconfigurable and sustainable liquid metal oxide as an adsorbent for efficient removal of the azo dye Ponceau S in water. The gallium-based alloy exhibits excellent reconfigurability and fluidity, allowing continuous production of surface gallium oxide for adsorption. The adsorption process is fast, energy-saving, and easily reversible. Furthermore, the electrical conductivity of liquid gallium enables impedance sensing for quantification of the adsorption process. This research provides a unique approach for the design and fabrication of adsorbents with continuous and multifunctional performance and opens up possibilities for applications in dye adsorption, environmental engineering, and molecular monitoring.
APPLIED MATERIALS TODAY
(2022)
Article
Biotechnology & Applied Microbiology
Shaowei Jia, He Gong, Yingying Zhang, Hongmei Liu, Haipeng Cen, Rui Zhang, Yubo Fan
Summary: This study assessed and predicted femoral strength and its influencing factors in elderly men with type 2 diabetes mellitus (T2DM). The results showed that femoral strength was higher in the T2DM group, which may be caused by higher bone mineral density and lower bone turnover rate. In addition to bone density and bone formation level, advanced glycation end products (AGEs), blood glucose, and age may significantly impact the prediction of femoral strength in T2DM.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Tianming Du, Zhengwei Li, Xiaoming Li, Xufeng Niu, Yubo Fan
Summary: By adjusting the charge balance mechanism of polyelectrolyte compounds and osmotic pressure, the formation of intrafibrillar mineralization is promoted, providing a basis for the preparation of biomimetic mineralized materials and the development of tissue engineering.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
