A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides

Rapid Characterization of a Mechanically Labile α-Helical Protein Enabled by Efficient Site-Specific Bioconjugation

(2017) Robert Walder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-molecule probing of amyloid nano-ensembles using the polymer nanoarray approach

(2017) Sibaprasad Maity et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Gating of TonB-dependent transporters by substrate-specific forced remodelling

(2017) Samuel J. Hickman et al.   Nature Communications

Direct Identification of Protein-Protein Interactions by Single-Molecule Force Spectroscopy

(2016) Andrés M. Vera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ESI-IMS–MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules

(2016) Lydia M. Young et al.   METHODS

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extraction of Accurate Biomolecular Parameters from Single-Molecule Force Spectroscopy Experiments

(2015) Oliver E. Farrance et al.   ACS Nano

Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry

(2015) Lydia M. Young et al.   ANALYST

Toxic species in amyloid disorders: Oligomers or mature fibrils

(2015) Vibha Taneja et al.   Annals of Indian Academy of Neurology

Direct Detection of α-Synuclein Dimerization Dynamics: Single-Molecule Fluorescence Analysis

(2015) Zhengjian Lv et al.   BIOPHYSICAL JOURNAL

A Flexible Nanoarray Approach for the Assembly and Probing of Molecular Complexes

(2015) Alexey V. Krasnoslobodtsev et al.   BIOPHYSICAL JOURNAL

pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers

(2015) Kevin W. Tipping et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging role of native mass spectrometry in characterizing the structure and dynamics of macromolecular complexes

(2015) Elisabetta Boeri Erba et al.   PROTEIN SCIENCE

Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein

(2015) Maria K. Janowska et al.   Scientific Reports

Folding of an Unfolded Protein by Macromolecular Crowding in Vitro

(2014) Jörgen Ådén et al.   BIOCHEMISTRY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein Misfolding Assessed with Single Molecule AFM Force Spectroscopy: Effect of Pathogenic Mutations

(2013) Alexey V. Krasnoslobodtsev et al.   BIOCHEMISTRY

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel polymer linkers for single molecule AFM force spectroscopy

(2013) Zenghan Tong et al.   METHODS

Mechanism of amyloid β−protein dimerization determined using single−molecule AFM force spectroscopy

(2013) Zhengjian Lv et al.   Scientific Reports

Unequivocal Single-Molecule Force Spectroscopy of Proteins by AFM Using pFS Vectors

(2012) Javier Oroz et al.   BIOPHYSICAL JOURNAL

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein

(2012) Alexey V. Krasnoslobodtsev et al.   PLoS One

Direct observation of multiple misfolding pathways in a single prion protein molecule

(2012) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common Features at the Start of the Neurodegeneration Cascade

(2012) Rubén Hervás et al.   PLOS BIOLOGY

Single-Molecule Atomic Force Microscopy Force Spectroscopy Study of Aβ-40 Interactions

(2011) Bo-Hyun Kim et al.   BIOCHEMISTRY

Nonspecific interactions in AFM force spectroscopy measurements

(2011) Emrah Celik et al.   JOURNAL OF MOLECULAR RECOGNITION

Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

(2011) Lucy A Woods et al.   Nature Chemical Biology

Environmental Conditions Affect the Kinetics of Nucleation of Amyloid Fibrils and Determine Their Morphology

(2010) Bertrand Morel et al.   BIOPHYSICAL JOURNAL

Nanoprobing of α-synuclein misfolding and aggregation with atomic force microscopy

(2010) Junping Yu et al.   Nanomedicine-Nanotechnology Biology and Medicine

Identification of a Mechanical Rheostat in the Hydrophobic Core of Protein L

(2009) David P. Sadler et al.   JOURNAL OF MOLECULAR BIOLOGY

Single homopolypeptide chains collapse into mechanically rigid conformations

(2009) L. Dougan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of α-synuclein in an aggregation prone state

(2009) Min-Kyu Cho et al.   PROTEIN SCIENCE

Pathogenic Mutations Shift the Equilibria of α-Synuclein Single Molecules towards Structured Conformers

(2008) Marco Brucale et al.   CHEMBIOCHEM

α-Synuclein Misfolding: Single Molecule AFM Force Spectroscopy Study

(2008) Junping Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Early Stages for Parkinson’s Development: α-Synuclein Misfolding and Aggregation

(2008) Junping Yu et al.   Journal of Neuroimmune Pharmacology

Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level

(2008) Massimo Sandal et al.   PLOS BIOLOGY