Metastatic prostate cancer-associated P62 inhibits autophagy flux and promotes epithelial to mesenchymal transition by sustaining the level of HDAC6

Elevation of SHARPIN Protein Levels in Prostate Adenocarcinomas Promotes Metastasis and Impairs Patient Survivals

(2017) Hai Huang et al.   PROSTATE

Loss of α-Tubulin Acetylation Is Associated with TGF-β-induced Epithelial-Mesenchymal Transition

(2016) Shuchen Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin

(2015) Fei Yue et al.   Aging-US

Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes

(2015) Qi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Elevated levels of mitochondrion-associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer

(2014) Xianhan Jiang et al.   CANCER

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Autophagy defects suggested by low levels of autophagy activator MAP1S and high levels of autophagy inhibitor LRPPRC predict poor prognosis of prostate cancer patients

(2014) Xianhan Jiang et al.   MOLECULAR CARCINOGENESIS

Inflammasome: Cancer's friend or foe?

(2014) Michela Terlizzi et al.   PHARMACOLOGY & THERAPEUTICS

Autophagy Inhibitor LRPPRC Suppresses Mitophagy through Interaction with Mitophagy Initiator Parkin

(2014) Jing Zou et al.   PLoS One

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability

(2013) Jing Zou et al.   BIOCHEMICAL JOURNAL

SQSTM1/p62 Interacts with HDAC6 and Regulates Deacetylase Activity

(2013) Jin Yan et al.   PLoS One

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

MAP1S enhances autophagy to suppress tumorigenesis

(2012) Leyuan Liu et al.   Autophagy

Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration

(2012) Yuichiro Miyaoka et al.   CURRENT BIOLOGY

Emerging avenues linking inflammation and cancer

(2012) Joydeb Kumar Kundu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fibrosis-dependent mechanisms of hepatocarcinogenesis

(2012) David Y. Zhang et al.   HEPATOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Autophagy Enhanced by Microtubule- and Mitochondrion-Associated MAP1S Suppresses Genome Instability and Hepatocarcinogenesis

(2011) R. Xie et al.   CANCER RESEARCH

Epithelial-to-mesenchymal transition in prostate cancer: paradigm or puzzle?

(2011) Jones T. Nauseef et al.   Nature Reviews Urology

Acetylated microtubules are required for fusion of autophagosomes with lysosomes

(2010) Rui Xie et al.   BMC CELL BIOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL