Autophagy Inhibitor LRPPRC Suppresses Mitophagy through Interaction with Mitophagy Initiator Parkin

Elevated levels of mitochondrion-associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer

(2014) Xianhan Jiang et al.   CANCER

Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability

(2013) Jing Zou et al.   BIOCHEMICAL JOURNAL

The significance of LRPPRC overexpression in gastric cancer

(2013) Xiaosa Li et al.   MEDICAL ONCOLOGY

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Profiling of Parkin-Binding Partners Using Tandem Affinity Purification

(2013) Alessandra Zanon et al.   PLoS One

MAP1S enhances autophagy to suppress tumorigenesis

(2012) Leyuan Liu et al.   Autophagy

Autophagy Enhanced by Microtubule- and Mitochondrion-Associated MAP1S Suppresses Genome Instability and Hepatocarcinogenesis

(2011) R. Xie et al.   CANCER RESEARCH

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

(2011) Saori R. Yoshii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Ubiquitinates Drp1 for Proteasome-dependent Degradation

(2011) Hongxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-associated Protein 1S (MAP1S) Bridges Autophagic Components with Microtubules and Mitochondria to Affect Autophagosomal Biogenesis and Degradation

(2011) Rui Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

(2011) Liliane Glauser et al.   JOURNAL OF NEUROCHEMISTRY

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies

(2010) Saroj P. Mathupala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Robust autophagy/mitophagy persists during mitosis

(2010) Leyuan Liu et al.   CELL CYCLE

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

(2010) Dong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea

(2010) Hélène Plun-Favreau et al.   PLoS Genetics

Parkin-induced mitophagy in the pathogenesis of Parkinson disease

(2009) Derek Narendra et al.   Autophagy

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function

(2009) Eleanor J. Davison et al.   PROTEOMICS

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

BCL-2 family antagonists for cancer therapy

(2008) Guillaume Lessene et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

(2008) Claire Henchcliffe et al.   Nature clinical practice. Neurology