Signal recognition particle binds to translating ribosomes before emergence of a signal anchor sequence

Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome

(2017) Ahmad Jomaa et al.   Nature Communications

The signal recognition particle contacts uL23 and scans substrate translation inside the ribosomal tunnel

(2017) Kärt Denks et al.   Nature Microbiology

The bacterial SRP receptor, FtsY, is activated on binding to the translocon

(2016) Albena Draycheva et al.   MOLECULAR MICROBIOLOGY

Cotranslational signal-independent SRP preloading during membrane targeting

(2016) Justin W. Chartron et al.   NATURE

Global profiling of SRP interaction with nascent polypeptides

(2016) Daniela Schibich et al.   NATURE

Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon

(2016) Ahmad Jomaa et al.   Nature Communications

Cotranslational protein folding on the ribosome monitored in real time

(2015) W. Holtkamp et al.   SCIENCE

Regulation of cargo recognition, commitment, and unloading drives cotranslational protein targeting

(2014) Ishu Saraogi et al.   JOURNAL OF CELL BIOLOGY

Lateral opening of the bacterial translocon on ribosome binding and signal peptide insertion

(2014) Yan Ge et al.   Nature Communications

Deducing the Kinetics of Protein Synthesis In Vivo from the Transition Rates Measured In Vitro

(2014) Sophia Rudorf et al.   PLoS Computational Biology

Protein translocation across the inner membrane of Gram-negative bacteria: the Sec and Tat dependent protein transport pathways

(2013) Renuka Kudva et al.   RESEARCH IN MICROBIOLOGY

Dynamic switch of the signal recognition particle from scanning to targeting

(2012) Wolf Holtkamp et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lipids Trigger a Conformational Switch That Regulates Signal Recognition Particle (SRP)-mediated Protein Targeting

(2011) Goran Stjepanovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

(2011) Jens Frauenfeld et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lipid activation of the signal recognition particle receptor provides spatial coordination of protein targeting

(2010) Vinh Q. Lam et al.   JOURNAL OF CELL BIOLOGY

Recognition of a signal peptide by the signal recognition particle

(2010) Claudia Y. Janda et al.   NATURE

Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting

(2010) X. Zhang et al.   SCIENCE

A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel

(2009) U. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Kinetic Explorer: A new computer program for dynamic simulation and fitting of kinetic data

(2008) Kenneth A. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Signal sequence–independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel

(2008) Thomas Bornemann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY