A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage

Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease

(2017) Parakkal Deepak et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

IL-36γ Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing via REG3A

(2017) Ziwei Jiang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-36γ signaling controls the induced regulatory T cell–Th9 cell balance via NFκB activation and STAT transcription factors

(2017) A Harusato et al.   Mucosal Immunology

An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target

(2017) Satveer K. Mahil et al.   Science Translational Medicine

The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases

(2016) Patrick T. Walsh et al.   Annals of the New York Academy of Sciences

Distinct expression of interleukin (IL)-36α, βandγ, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease

(2016) M.-A. Boutet et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytokines and intestinal inflammation

(2016) Giorgos Bamias et al.   CURRENT OPINION IN GASTROENTEROLOGY

Suppression of innate inflammation and immunity by interleukin-37

(2016) Charles A. Dinarello et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

(2016) Anny-Claude Luissint et al.   GASTROENTEROLOGY

IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo

(2016) Kristina Scheibe et al.   GUT

Increased Expression of Interleukin-36, a Member of the Interleukin-1 Cytokine Family, in Inflammatory Bowel Disease

(2016) Atsushi Nishida et al.   INFLAMMATORY BOWEL DISEASES

mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production

(2016) Feidi Chen et al.   JOURNAL OF IMMUNOLOGY

IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation

(2016) S E Russell et al.   Mucosal Immunology

NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury

(2016) S S Seregin et al.   Mucosal Immunology

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation

(2016) Konrad Aden et al.   Cell Reports

Interleukin-22: Immunobiology and Pathology

(2015) Jarrod A. Dudakov et al.   Annual Review of Immunology

The interleukin (IL)-1 cytokine family – Balance between agonists and antagonists in inflammatory diseases

(2015) Jennifer Palomo et al.   CYTOKINE

Innate Cytokines Dictate the Fate of Acute Intestinal Inflammation

(2015) Giorgos Bamias et al.   GASTROENTEROLOGY

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage

(2015) Oscar Medina-Contreras et al.   JOURNAL OF IMMUNOLOGY

Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions

(2015) Cem Gabay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions

(2015) Laurel A. Monticelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin (IL)-1β Is a Strong Inducer of IL-36γ Expression in Human Colonic Myofibroblasts

(2015) Kenichiro Takahashi et al.   PLoS One

IL-36γ Sustains a Proinflammatory Self-amplifying Loop with IL-17C in Anti-TNF–induced Psoriasiform Skin Lesions of Patients with Crohnʼs Disease

(2014) Matthias Friedrich et al.   INFLAMMATORY BOWEL DISEASES

Alarmin Function of Cathelicidin Antimicrobial Peptide LL37 through IL-36γ Induction in Human Epidermal Keratinocytes

(2014) Na Li et al.   JOURNAL OF IMMUNOLOGY

IL-36 has proinflammatory effects in skin but not in joints

(2014) Damien Dietrich et al.   Nature Reviews Rheumatology

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota

(2014) V. F.-S. Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice

(2013) Marina Bersudsky et al.   GUT

IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

(2013) L. A. Zenewicz et al.   JOURNAL OF IMMUNOLOGY

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

(2013) Ansuman T Satpathy et al.   NATURE IMMUNOLOGY

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

(2013) C. L. Zindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of IL-36 cytokines and their role in disease

(2013) Mark S. Gresnigt et al.   SEMINARS IN IMMUNOLOGY

Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease

(2013) Loris R. Lopetuso et al.   Frontiers in Immunology

New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation

(2012) Giorgos Bamias et al.   CYTOKINE

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

Healing of intestinal inflammation by IL-22

(2012) Atsushi Mizoguchi   INFLAMMATORY BOWEL DISEASES

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity

(2011) Peter J. Morrison et al.   IMMUNOLOGY

Recent advances in IL-22 biology

(2011) L. A. Zenewicz et al.   INTERNATIONAL IMMUNOLOGY

Functional Specializations of Intestinal Dendritic Cell and Macrophage Subsets That Control Th17 and Regulatory T Cell Responses Are Dependent on the T Cell/APC Ratio, Source of Mouse Strain, and Regional Localization

(2011) T. L. Denning et al.   JOURNAL OF IMMUNOLOGY

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

Interleukin 37 expression protects mice from colitis

(2011) E. N. McNamee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

(2010) K. P. A. MacDonald et al.   BLOOD

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Interleukin-22-Producing Natural Killer Cells and Lymphoid Tissue Inducer-like Cells in Mucosal Immunity

(2009) Marco Colonna   IMMUNITY

Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells

(2009) Amit Awasthi et al.   JOURNAL OF IMMUNOLOGY

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

(2008) Ken Sugimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE