Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Article
Engineering, Biomedical
Lipeng Qiao, Yongping Liang, Jueying Chen, Ying Huang, Saeed A. Alsareii, Abdulrahman Manaa Alamri, Farid A. Harraz, Baolin Guo
Summary: In this study, adhesive self-healing conductive antibacterial hydrogel dressings were prepared for the repair of infected wounds. The hydrogel exhibited self-healing properties, good conductivity, photothermal anti-bacterial properties, and improved wound healing in the infected skin wound repair test. These hydrogels have potential as promising candidates for wound healing dressings for the treatment of infected skin wounds.
BIOACTIVE MATERIALS
(2023)
Article
Immunology
Fang Zhang, Ye Liu, Shiqi Wang, Xin Yan, Yue Lin, Deyan Chen, Qian Tan, Zhiwei Wu
Summary: In this study, we found that interleukin 25 (IL-25) can promote diabetic wound healing by mediating IL-17RB signaling. IL-25 improves angiogenesis and collagen deposition, thus improving the wound healing process. Additionally, IL-25 protects endothelial cells from high glucose damage, promoting cell migration and tube formation. This study provides a new therapeutic strategy for treating poor healing diabetic wounds.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zilong Fang, Tao Lin, Shuai Fan, Xing Qiu, Ziqing Zhong, Ganghua Yang, Jianqiu Yang, Guoqing Zhang, Yang Feng, Fanrong Ai, Qingming Shi, Wenbing Wan
Summary: This study discovered and constructed a novel injectable hydrogel wound dressing based on carboxymethyl chitosan (CMCS) and polyethylenimine (PEI). The hydrogel has good injectability, biocompatibility, antibacterial properties, and certain adhesion properties, which can promote wound healing and cell repair with broad application prospects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Zhi-You He, Mi-Tao Huang, Xu Cui, Si-Tuo Zhou, Ying Wu, Pi-Hong Zhang, Jie Zhou
Summary: The study revealed that GAS5 sponged miR-217 to up-regulate Prox1, promoting lymphangiogenesis and diabetic wound healing. This finding may offer a novel therapeutic strategy to enhance the efficacy of diabetic wound healing.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Quentin D'Arcy, Mehrnaz Gharaee-Kermani, Alisa Zhilin-Roth, Jill A. Macoska
Summary: The IL-4/IL-13 signaling axis plays a crucial role in the development of lower urinary tract symptoms. IL-4 and IL-13 promote the activation of prostate fibroblasts and the secretion of extracellular matrix, leading to fibrosis. These findings have important clinical implications for the treatment of lower urinary tract symptoms.
Article
Microbiology
Xu Wang, Shuangshaung Wu, Wenjie Wu, Wenqing Zhang, Linman Li, Qian Liu, Zhimin Yan
Summary: This study found that Candida albicans infection can promote the occurrence and progression of oral cancer, and attract tumor-associated macrophages (TAMs) infiltration. Further analysis showed that the activation of the IL-17A/IL-17RA signaling pathway played an important role in excessive TAMs infiltration in the tumor inflammatory microenvironment caused by Candida infection.
Article
Oncology
Muna Poudel, Poshan Yugal Bhattarai, Pratikshya Shrestha, Hong Seok Choi
Summary: IL-36 gamma plays a pivotal role in breast cancer by promoting the proliferation and transformation of epithelial cells through the activation of multiple signaling pathways and transcription factors. PIN1 is crucial in regulating IL-36 gamma-induced mammary gland tumorigenesis.
Article
Engineering, Biomedical
Wangbei Cao, Shiqiao Peng, Yuejun Yao, Jieqi Xie, Shifen Li, Chenxi Tu, Changyou Gao
Summary: A wound dressing with immunomodulation and electroconductivity properties was prepared and tested for its effectiveness in promoting diabetic wound healing. The dressing successfully accelerated skin regeneration, collagen deposition, revascularization, and re-epithelialization in diabetic wounds. It achieved this by regulating the wound microenvironment, scavenging reactive oxygen species (ROS), and polarizing macrophages to the M2 phenotype.
ACTA BIOMATERIALIA
(2022)
Article
Oncology
Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen, Hai Rao
Summary: PRMT5 and LSD1 form a complex with Slug and promote breast cancer invasion. They inhibit E-cadherin expression and activate vimentin expression through dual transcriptional activities. Both PRMT5 and LSD1 are coordinately expressed in breast cancer patients and simultaneous inhibition of both proteins shows a synergetic effect in inhibiting breast tumor growth and metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell & Tissue Engineering
Yi Li, Yujun Xu, Xinhan Liu, Xin Yan, Yue Lin, Qian Tan, Yayi Hou
Summary: The study found that the wound healing process in diabetic patients is slow, with abnormal accumulation of MDSCs and activation of the mTOR signaling pathway. Treatment with the mTOR signaling inhibitor INK128 can reduce MDSCs and promote wound healing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Ophthalmology
Xihong Lan, Wang Zhang, Jin Zhu, Huaxing Huang, Kunlun Mo, Huizhen Guo, Liqiong Zhu, Jiafeng Liu, Mingsen Li, Li Wang, Chunqiao Liu, Jianping Ji, Hong Ouyang
Summary: This study investigates the role of dsRNA and its regulatory network in corneal wound healing. The results show that dsRNA activates IFN-I signaling, primarily IFN-beta, to promote corneal epithelial reconstruction, and identify MMP13 as a downstream effector in this process.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Livia Interdonato, Ylenia Marino, Gianluca Antonio Franco, Alessia Arangia, Ramona D'Amico, Rosalba Siracusa, Marika Cordaro, Daniela Impellizzeri, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Recently, wound healing has become a topic of increased interest in both scientific and clinical communities. The study aimed to investigate the molecular mechanism of acai berry in wound healing using a mouse model. The results showed that acai berry could modulate the Wnt/beta-catenin pathway, reducing the expression of Wnt3a and FZ8, and the accumulation of beta-catenin. It also showed anti-inflammatory activities by reducing the expression of TNF-alpha and IL-18, and modulating the NF-kappa B pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Chen-Hung Lee, Dong-Yi Chen, Ming-Jer Hsieh, Kuo-Chun Hung, Shu-Chun Huang, Chia-Jung Cho, Shih-Jung Liu
Summary: This study developed an advanced and encouraging vehicle to improve clinically applicable diabetic wound care. Nanofibrous insulin/vildagliptin core-shell biodegradable (PLGA) scaffolds were prepared to deliver vildagliptin and insulin for the repair of diabetic wounds. The core-shell nanofibrous scaffolds released vildagliptin and insulin effectively and accelerated wound healing. The insulin/vildagliptin-loaded core-shell nanofibers extended drug delivery and enhanced wound repair associated with diabetes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xi Chen, Yizhong Peng, Hang Xue, Guohui Liu, Ning Wang, Zengwu Shao
Summary: This study identified a promising option for diabetic wound treatment in the form of a modified graphene oxide-based wound dressing material. The biomaterial was found to enhance the secretion of small extracellular vesicles containing miR-21, promoting wound healing. Additionally, a key axis related to DFU wound healing was discovered through bioinformatics analysis and experiments.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)