Ligand channel in pharmacologically stabilized rhodopsin

Structural role of the T94I rhodopsin mutation in congenital stationary night blindness

(2016) Ankita Singhal et al.   EMBO REPORTS

Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state

(2016) Christopher T. Schafer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological folding chaperones act as allosteric ligands of Frizzled4

(2015) Serena F Generoso et al.   Nature Chemical Biology

Characterization of the Simultaneous Decay Kinetics of Metarhodopsin States II and III in Rhodopsin by Solution-State NMR Spectroscopy

(2014) Jochen Stehle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chaperoning G Protein-Coupled Receptors: From Cell Biology to Therapeutics

(2014) Ya-Xiong Tao et al.   ENDOCRINE REVIEWS

Conformational Selection and Equilibrium Governs the Ability of Retinals to Bind Opsin

(2014) Christopher T. Schafer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive phospholipid scramblase activity of a G protein-coupled receptor

(2014) Michael A. Goren et al.   Nature Communications

Opsin, a Structural Model for Olfactory Receptors?

(2013) Jung Hee Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into congenital stationary night blindness based on the structure of G90D rhodopsin

(2013) Ankita Singhal et al.   EMBO REPORTS

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy

(2013) J. A. Janovick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin A Metabolism in Rod and Cone Visual Cycles

(2012) John C. Saari   Annual Review of Nutrition

Effect of channel mutations on the uptake and release of the retinal ligand in opsin

(2012) R. Piechnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Fluorescence-Detection Size-Exclusion Chromatography-Based Thermostability Assay for Membrane Protein Precrystallization Screening

(2012) Motoyuki Hattori et al.   STRUCTURE

Preparation of an Activated Rhodopsin/Transducin Complex Using a Constitutively Active Mutant of Rhodopsin

(2011) Guifu Xie et al.   BIOCHEMISTRY

Retinitis Pigmentosa: Genes and Disease Mechanisms

(2011) Francesco Parmeggiani et al.   CURRENT GENOMICS

Structural insights into agonist-induced activation of G-protein-coupled receptors

(2011) Xavier Deupi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of the human histamine H1 receptor complex with doxepin

(2011) Tatsuro Shimamura et al.   NATURE

The structural basis of agonist-induced activation in constitutively active rhodopsin

(2011) Jörg Standfuss et al.   NATURE

Molecular Basis of Ligand Dissociation in β-Adrenergic Receptors

(2011) Angel González et al.   PLoS One

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

(2011) X. Deupi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinobenzaldehydes as proper-trafficking inducers of folding-defective P23H rhodopsin mutant responsible for Retinitis Pigmentosa

(2010) Kenji Ohgane et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ligand Entry and Exit Pathways in the β2-Adrenergic Receptor

(2009) Ting Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Mechanisms of Rhodopsin Retinitis Pigmentosa and the Efficacy of Pharmacological Rescue

(2009) Mark P. Krebs et al.   JOURNAL OF MOLECULAR BIOLOGY

Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa

(2008) Hugo F. Mendes et al.   HUMAN MOLECULAR GENETICS

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE

Microscale Fluorescent Thermal Stability Assay for Membrane Proteins

(2008) Alexander I. Alexandrov et al.   STRUCTURE