Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

(2016) Libin Ye et al.   NATURE

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

(2016) Brian T. DeVree et al.   NATURE

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

(2016) Dean P. Staus et al.   NATURE

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1

(2015) Jonathan F. Fay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distance Mapping in Proteins Using Fluorescence Spectroscopy: Tyrosine, like Tryptophan, Quenches Bimane Fluorescence in a Distance-Dependent Manner

(2014) Amber M. Jones Brunette et al.   BIOCHEMISTRY

Rhodopsin TM6 Can Interact with Two Separate and Distinct Sites on Arrestin: Evidence for Structural Plasticity and Multiple Docking Modes in Arrestin–Rhodopsin Binding

(2014) Abhinav Sinha et al.   BIOCHEMISTRY

Binding Specificity of Retinal Analogs to Photoactivated Visual Pigments Suggest Mechanism for Fine-Tuning GPCR-Ligand Interactions

(2014) Sundaramoorthy Srinivasan et al.   CHEMISTRY & BIOLOGY

Conformational Selection and Equilibrium Governs the Ability of Retinals to Bind Opsin

(2014) Christopher T. Schafer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficiencies of Activation of Transducin by Cone and Rod Visual Pigments

(2013) Yasushi Imamoto et al.   BIOCHEMISTRY

Asymmetry of the rhodopsin dimer in complex with transducin

(2013) Beata Jastrzebska et al.   FASEB JOURNAL

A Constitutively Activating Mutation Alters the Dynamics and Energetics of a Key Conformational Change in a Ligand-free G Protein-coupled Receptor

(2013) Hisao Tsukamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Release of Retinal from a Cone Visual Pigment following Photoactivation

(2012) Min-Hsuan Chen et al.   BIOCHEMISTRY

A Key Agonist-induced Conformational Change in the Cannabinoid Receptor CB1 Is Blocked by the Allosteric Ligand Org 27569

(2012) Jonathan F. Fay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin

(2012) Martha E. Sommer et al.   Nature Communications

Alkylated Hydroxylamine Derivatives Eliminate Peripheral Retinylidene Schiff Bases but Cannot Enter the Retinal Binding Pocket of Light-Activated Rhodopsin

(2011) Ronny Piechnick et al.   BIOCHEMISTRY

Preparation of an Activated Rhodopsin/Transducin Complex Using a Constitutively Active Mutant of Rhodopsin

(2011) Guifu Xie et al.   BIOCHEMISTRY

Rod and Cone Visual Pigments and Phototransduction through Pharmacological, Genetic, and Physiological Approaches

(2011) Vladimir J. Kefalov   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemistry and Biology of Vision

(2011) Krzysztof Palczewski   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved Tyr2235.58Plays Different Roles in the Activation and G-Protein Interaction of Rhodopsin

(2011) Matthias Elgeti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of metarhodopsin II

(2011) Hui-Woog Choe et al.   NATURE

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

(2011) X. Deupi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What site-directed labeling studies tell us about the mechanism of rhodopsin activation and G-protein binding

(2010) David L. Farrens   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function

(2010) Xavier Deupi et al.   PHYSIOLOGY

Highly conserved tyrosine stabilizes the active state of rhodopsin

(2010) J. A. Goncalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Magnitude of the Light-induced Conformational Change in Different Rhodopsins Correlates with Their Ability to Activate G Proteins

(2009) Hisao Tsukamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A G protein-coupled receptor at work: the rhodopsin model

(2009) Klaus Peter Hofmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

11-cis- and All-trans-Retinols Can Activate Rod Opsin: Rational Design of the Visual Cycle†

(2008) Masahiro Kono et al.   BIOCHEMISTRY