Lifetime of muscarinic receptor–G-protein complexes determines coupling efficiency and G-protein subtype selectivity

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

(2016) Brian T. DeVree et al.   NATURE

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

(2016) David M. Thal et al.   NATURE

Universal allosteric mechanism for Gα activation by GPCRs

(2015) Tilman Flock et al.   NATURE

Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution

(2015) Matthias Hillenbrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term exposure to muscarinic agonists decreases expression of contractile proteins and responsiveness of rabbit tracheal smooth muscle cells

(2014) Rodopi Stamatiou et al.   BMC Pulmonary Medicine

Dynamics of Gαi1interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production

(2013) Markus Milde et al.   BIOCHEMICAL JOURNAL

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

(2012) Kazuko Haga et al.   NATURE

Classification of G proteins and prediction of GPCRs-G proteins coupling specificity using continuous wavelet transform and information theory

(2011) Zhanchao Li et al.   AMINO ACIDS

Activation of M3 muscarinic receptors inhibits T-type Ca2+ channel currents via pertussis toxin-sensitive novel protein kinase C pathway in small dorsal root ganglion neurons

(2011) Yiming Zhang et al.   CELLULAR SIGNALLING

G Proteins in Reverse Mode

(2010) Leif G. Hommers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effect of detergents on trimeric G-protein activity in isolated plasma membranes from rat brain cortex: Correlation with studies of DPH and Laurdan fluorescence

(2008) J. Sýkora et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Coupling mode of receptors and G proteins

(2008) Peter Hein et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY