Shared epitope–aryl hydrocarbon receptor crosstalk underlies the mechanism of gene–environment interaction in autoimmune arthritis

Cigarette Smoke Induces Immune Responses to Vimentin in both, Arthritis-Susceptible and -Resistant Humanized Mice

(2016) Mitali Bidkar et al.   PLoS One

Notch-regulated miR-223 targets the aryl hydrocarbon receptor pathway and increases cytokine production in macrophages from rheumatoid arthritis patients

(2016) Jesús Ogando et al.   Scientific Reports

Aryl Hydrocarbon Receptors in Osteoclast Lineage Cells Are a Negative Regulator of Bone Mass

(2015) Tai-yong Yu et al.   PLoS One

Shared Epitope-Antagonistic Ligands: A New Therapeutic Strategy in Mice With Erosive Arthritis

(2015) Song Ling et al.   Arthritis & Rheumatology

Delineating the Role of the HLA-DR4 "Shared Epitope" in Susceptibility versus Resistance to Develop Arthritis

(2014) V. Taneja et al.   JOURNAL OF IMMUNOLOGY

The aryl hydrocarbon receptor suppresses osteoblast proliferation and differentiation through the activation of the ERK signaling pathway

(2014) Haitao Yu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cross-talk between Aryl Hydrocarbon Receptor and the Inflammatory Response

(2013) Christoph F. A. Vogel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dominant Negative MCP-1 Blocks Human Osteoclast Differentiation

(2013) Nigel A. Morrison et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A Small Shared Epitope-Mimetic Compound Potently Accelerates Osteoclast-Mediated Bone Damage in Autoimmune Arthritis

(2013) J. Fu et al.   JOURNAL OF IMMUNOLOGY

On the Origin of Rheumatoid Arthritis: The Impact of Environment and Genes—A Population Based Twin Study

(2013) Anders J. Svendsen et al.   PLoS One

C/EBP  regulates osteoclast lineage commitment

(2013) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes

(2013) J. Iqbal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Citrullinated calreticulin potentiates rheumatoid arthritis shared epitope signaling

(2012) Song Ling et al.   ARTHRITIS AND RHEUMATISM

The environment and the origins of islet autoimmunity and Type 1 diabetes

(2012) S. Eringsmark Regnéll et al.   DIABETIC MEDICINE

Epidemiology of environmental exposures and human autoimmune diseases: Findings from a National Institute of Environmental Health Sciences Expert Panel Workshop

(2012) Frederick W. Miller et al.   JOURNAL OF AUTOIMMUNITY

Mechanisms of environmental influence on human autoimmunity: A national institute of environmental health sciences expert panel workshop

(2012) Carlo Selmi et al.   JOURNAL OF AUTOIMMUNITY

An HLA-DRB1-Coded Signal Transduction Ligand Facilitates Inflammatory Arthritis: A New Mechanism of Autoimmunity

(2012) J. Holoshitz et al.   JOURNAL OF IMMUNOLOGY

Constitutively Active Canonical NF-κB Pathway Induces Severe Bone Loss in Mice

(2012) Jesse E. Otero et al.   PLoS One

Environmental and Gene-Environment Interactions and Risk of Rheumatoid Arthritis

(2012) Elizabeth W. Karlson et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis

(2012) Marina G Kazantseva et al.   ARTHRITIS RESEARCH & THERAPY

Developing potent backbone cyclic peptides bearing the shared epitope sequence as rheumatoid arthritis drug-leads

(2011) Shirly Naveh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New insights into the functional role of the rheumatoid arthritis shared epitope

(2011) Denise E. de Almeida et al.   FEBS LETTERS

Understanding joint damage and physical disability in RA

(2011) Yvonne M. R. de Punder et al.   Nature Reviews Rheumatology

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

A role for calreticulin in the pathogenesis of rheumatoid arthritis

(2010) Joseph Holoshitz et al.   Annals of the New York Academy of Sciences

Immune Dysregulation by the Rheumatoid Arthritis Shared Epitope

(2010) D. E. De Almeida et al.   JOURNAL OF IMMUNOLOGY

Identification of the Rheumatoid Arthritis Shared Epitope Binding Site on Calreticulin

(2010) Song Ling et al.   PLoS One

Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis

(2009) E W Karlson et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1β through the NF-κB and MAPK pathways in rheumatoid arthritis

(2009) Wenxin Zheng et al.   ARTHRITIS AND RHEUMATISM

Gene discovery in rheumatoid arthritis highlights the CD40/NF-ĸB signaling pathway in disease pathogenesis

(2009) Lindsey A. Criswell   IMMUNOLOGICAL REVIEWS

Neonatal Exposure to Low-Dose 2,3,7,8-Tetrachlorodibenzo- p -Dioxin Causes Autoimmunity Due to the Disruption of T Cell Tolerance

(2009) Naozumi Ishimaru et al.   JOURNAL OF IMMUNOLOGY

The aryl hydrocarbon receptor in immunity

(2009) Charlotte Esser et al.   TRENDS IN IMMUNOLOGY

Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

(2008) D Makrygiannakis et al.   ANNALS OF THE RHEUMATIC DISEASES

Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells

(2008) Marc Veldhoen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis

(2008) S. Kobayashi et al.   RHEUMATOLOGY