Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 115, Issue 10, Pages 2455-2460
Publisher
Proceedings of the National Academy of Sciences
Online
2018-02-21
DOI
10.1073/pnas.1712107115
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action
- (2017) Wenwen Du et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
- (2016) Ana C. Anderson et al. IMMUNITY
- Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation
- (2015) Binh L. Phong et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Overcoming T cell exhaustion in infection and cancer
- (2015) Kristen E. Pauken et al. TRENDS IN IMMUNOLOGY
- Regulation of T cell responses by the receptor molecule Tim-3
- (2014) Jacob V. Gorman et al. IMMUNOLOGIC RESEARCH
- Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion
- (2014) Robert L. Ferris et al. JOURNAL OF IMMUNOLOGY
- Tim-3 Directly Enhances CD8 T Cell Responses to Acute Listeria monocytogenes Infection
- (2014) J. V. Gorman et al. JOURNAL OF IMMUNOLOGY
- Tim-3: An Activation Marker and Activation Limiter of Innate Immune Cells
- (2013) Gencheng Han et al. Frontiers in Immunology
- Endogenous antigen tunes the responsiveness of naive B cells but not T cells
- (2012) Julie Zikherman et al. NATURE
- An intermediate dose of LCMV clone 13 causes prolonged morbidity that is maintained by CD4+ T cells
- (2012) Andrew Stamm et al. VIROLOGY
- Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions
- (2012) Yueqin Qiu et al. PLoS Pathogens
- Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism
- (2011) Andrew N. Macintyre et al. IMMUNITY
- Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways
- (2011) J. Lee et al. MOLECULAR AND CELLULAR BIOLOGY
- T cell exhaustion
- (2011) E John Wherry NATURE IMMUNOLOGY
- HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression
- (2010) Bahareh Vali et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin
- (2010) Rajesh R. Rao et al. IMMUNITY
- Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity
- (2010) Rachel H. McMahan et al. JOURNAL OF CLINICAL INVESTIGATION
- Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients
- (2010) Julien Fourcade et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
- (2010) Kaori Sakuishi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Regulation of Virus-Specific CD4+ T Cell Function by Multiple Costimulatory Receptors during Chronic HIV Infection
- (2010) A. Kassu et al. JOURNAL OF IMMUNOLOGY
- Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival
- (2010) T. W. Hand et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
- (2010) H.-T. Jin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTOR regulates memory CD8 T-cell differentiation
- (2009) Koichi Araki et al. NATURE
- Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
- (2008) R. Brad Jones et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
- (2008) Yoichi Maekawa et al. NATURE IMMUNOLOGY
- Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo
- (2007) Megan M. McCausland et al. JOURNAL OF VIROLOGICAL METHODS
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started