Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation

Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses

(2015) Tina L. Sumpter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TIMgenes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

(2015) Gordon J. Freeman et al.   IMMUNOLOGICAL REVIEWS

Optimal Aggregation of FcεRI with a Structurally Defined Trivalent Ligand Overrides Negative Regulation Driven by Phosphatases

(2014) Avanika Mahajan et al.   ACS Chemical Biology

Quantification of tryptase-TIM-3 double-positive mast cells in human chronic periodontitis

(2014) Shiguang Huang et al.   ARCHIVES OF ORAL BIOLOGY

NR4A nuclear receptors are orphans but not lonesome

(2014) Kondababu Kurakula et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Orchestrating immune check-point blockade for cancer immunotherapy in combinations

(2014) Jose Luis Perez-Gracia et al.   CURRENT OPINION IN IMMUNOLOGY

Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells

(2014) Chuan Wu et al.   IMMUNITY

Regulation of T cell responses by the receptor molecule Tim-3

(2014) Jacob V. Gorman et al.   IMMUNOLOGIC RESEARCH

Immunoregulation of Dendritic Cells by the Receptor T cell Ig and Mucin Protein-3 via Bruton’s Tyrosine Kinase and c-Src

(2014) Neeraj Maurya et al.   JOURNAL OF IMMUNOLOGY

Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion

(2014) Robert L. Ferris et al.   JOURNAL OF IMMUNOLOGY

Tim-3 Directly Enhances CD8 T Cell Responses to Acute Listeria monocytogenes Infection

(2014) J. V. Gorman et al.   JOURNAL OF IMMUNOLOGY

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

(2014) Yu-Hwa Huang et al.   NATURE

Tim-3: An Emerging Target in the Cancer Immunotherapy Landscape

(2014) A. C. Anderson   Cancer Immunology Research

Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade

(2014) I. P. da Silva et al.   Cancer Immunology Research

T Cell Ig Mucin-3 Promotes Homeostasis of Sepsis by Negatively Regulating the TLR Response

(2013) X. Yang et al.   JOURNAL OF IMMUNOLOGY

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

Tim-3: An Activation Marker and Activation Limiter of Innate Immune Cells

(2013) Gencheng Han et al.   Frontiers in Immunology

Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells

(2012) R. G. Veenstra et al.   BLOOD

Molecular Pathways: The Role of NR4A Orphan Nuclear Receptors in Cancer

(2012) H. M. Mohan et al.   CLINICAL CANCER RESEARCH

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

(2012) Julie Zikherman et al.   NATURE

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion

(2012) Manu Rangachari et al.   NATURE MEDICINE

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways

(2011) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of mitogen activated protein kinase-Erk kinase (MEK) increases T cell immunoglobulin mucin domain-3 (TIM-3) transcription in human T lymphocytes and a human mast cell line

(2011) Soo-Jin Yoon et al.   MOLECULAR IMMUNOLOGY

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

NR4A Orphan Nuclear Receptors

(2010) Yue Zhao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Galectin-9 induces osteoblast differentiation through the CD44/Smad signaling pathway

(2010) Rena Tanikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells

(2010) V. Dardalhon et al.   JOURNAL OF IMMUNOLOGY

Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: Implications for regulation of IgE-mediated degranulation

(2010) Michael P. Sanderson et al.   MOLECULAR IMMUNOLOGY

Ubiquitination and endocytosis of the high affinity receptor for IgE

(2010) Rosa Molfetta et al.   MOLECULAR IMMUNOLOGY

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tyrosine kinase network regulating mast cell activation

(2009) Alasdair M. Gilfillan et al.   IMMUNOLOGICAL REVIEWS

Galectin-9 Is a High Affinity IgE-binding Lectin with Anti-allergic Effect by Blocking IgE-Antigen Complex Formation

(2009) Toshiro Niki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Minor Catalytic Activity of Src Family Kinases Is Sufficient for Maximal Activation of Mast Cells via the High-Affinity IgE Receptor

(2009) Michael Poderycki et al.   JOURNAL OF IMMUNOLOGY

Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices

(2008) A. Nobumoto et al.   GLYCOBIOLOGY

Amplification mechanisms for the enhancement of antigen-mediated mast cell activation

(2008) Alasdair M. Gilfillan et al.   IMMUNOLOGIC RESEARCH

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New developments in mast cell biology

(2008) Janet Kalesnikoff et al.   NATURE IMMUNOLOGY

The multiple roles of phosphoinositide 3-kinase in mast cell biology

(2008) Mi-Sun Kim et al.   TRENDS IN IMMUNOLOGY