Article
Biochemistry & Molecular Biology
Jeong Woo Kim, Jinwon Choi, Moon Nyeo Park, Bonglee Kim
Summary: Pancreatic cancer is the seventh leading cause of cancer-related mortality. Gallic acid, as a potential anticancer agent, has shown inhibitory effects on cell proliferation and induction of apoptosis in pancreatic cancer cells. It activates the p38 pathway and endoplasmic reticulum stress pathway through the generation of reactive oxygen species, suggesting its therapeutic potential for pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Meghashyama Prabhakara Bhat, Bidhayak Chakraborty, Shashiraj Kareyellappa Nagaraja, Pooja Vidyasagar Gunagambhire, Raju Suresh Kumar, Sreenivasa Nayaka, Abdulrahman I. Almansour, Karthikeyan Perumal
Summary: Nowadays, the increased number of multidrug-resistant strains among pathogens and the threat of cancer pose serious public health concerns. In this study, bioactive secondary metabolites from Aspergillus niger CJ6 were extracted, characterized, and evaluated for their antimicrobial, antifungal, and anticancer activities. The crude ethyl acetate extract displayed increasing antimicrobial activity with concentration and showed promising potential against Shigella flexneri. The extract also exhibited moderate cytotoxic activity against MIA PaCa-2 cell line, inducing apoptosis in a dose-dependent manner. These findings suggest the need for further exploration and development of novel bioactive agents to combat fatal diseases in humans.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kirill Nikitich Kashkin, Elena Sergeevna Kotova, Irina Vasilievna Alekseenko, Svetlana Sergeevna Bulanenkova, Sergey Borisovich Akopov, Eugene Pavlovich Kopantzev, Lev Grigorievich Nikolaev, Igor Pavlovich Chernov, Dmitry Alexandrovich Didych
Summary: A library of active genome regulatory elements from MIA PaCa-2 pancreatic adenocarcinoma cells was constructed using ChIP-lentiMPRA. Highly expressed genes were found to be enriched in those associated with multiple distal regions, while genes associated with 1-2 distal regions or proximal regions were more often related to housekeeping functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Nunzia Novizio, Raffaella Belvedere, Elva Morretta, Richard Tomasini, Maria Chiara Monti, Silvana Morello, Antonello Petrella
Summary: This study highlights the importance of using in vitro three-dimensional models for studying pancreatic cancer and the role of Annexin A1 (ANXA1) in these models. The results suggest that ANXA1 can influence the formation, stability, and drug resistance of pancreatic cancer models, and the extracellular ANXA1 action is strengthened through extracellular vesicles. Therefore, ANXA1 may serve as a potential therapeutic target for pancreatic cancer.
Article
Chemistry, Medicinal
Chao-Wen Hsueh, Chun Chen, Po-Yen Chiu, Ni-Na Chiang, Chi-Cheng Lu, Jai-Sing Yang, Fu-An Chen
Summary: Research has indicated that BITC induces apoptotic cell death in gemcitabine-resistant pancreatic cancer cells through a mitochondrial-dependent signaling pathway.
PHARMACOGNOSY MAGAZINE
(2022)
Article
Medicine, Research & Experimental
Fangfang Zhu, Jie Gao, Fuling Zeng, Yuling Lai, Xiaofeng Ruan, Gaopi Deng
Summary: This study investigated the protective effects and mechanisms of hyperoside against cyclophosphamide-induced ovarian damage and reduced fertility. The results showed that hyperoside can diminish follicular depletion, prevent excessive hypoxia and autophagy activation, and increase follicular reserve, thereby improving fertility in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Nguyen Duy Phan, Ashraf M. Omar, Sijia Sun, Juthamart Maneenet, Dya Fita Dibwe, Mao Sato, Surya Kant Kalauni, Naoki Toyooka, Tsutomu Fujii, Suresh Awale
Summary: An ethanolic extract of Abies spectabilis stem demonstrated strong cytotoxicity against MIA PaCa-2 pancreatic cancer cells, particularly under nutrient-deprived conditions. Further investigation led to the isolation of ten compounds, including a new abietane-type diterpene. The most potent compound, dehydroabietinol, not only exhibited strong anti-cancer activity but also showed potential as an anti-metastatic agent.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Multidisciplinary Sciences
Lingxia Chen, Zhi Qin, Zhong-bao Ruan
Summary: This study found that hyperoside, a flavonoid glycoside extracted from herbs, can alleviate apoptosis in cardiomyocytes induced by doxorubicin (DOX) by inhibiting the ASK1/p38 signaling pathway, thereby protecting the heart from DOX-induced cardiotoxicity. However, hyperoside does not affect the cytotoxicity of DOX in MDA-MB-231 cells.
Article
Plant Sciences
Kai Sun, Jiahui Luo, Xingzhi Jing, Wei Xiang, Jiachao Guo, Xudong Yao, Shuang Liang, Fengjing Guo, Tao Xu
Summary: The study demonstrated that Hyperoside (Hyp) can inhibit IL-1 beta-induced apoptosis and inflammatory responses in chondrocytes, while regulating the expression of key proteins, suggesting its potential for the treatment of osteoarthritis.
Article
Chemistry, Physical
Abdul Rahman, N. Prashanth, B. N. Nippu, H. M. Kumaraswamy, A. N. Rajeshwara, N. D. Satyanarayan
Summary: Indole is an important component in evaluating anticancer agents for its versatility and biodiversity. A series of 3-methyl-indole-2-pyridine secondary amines has been synthesized and shown potential binding and inhibitory activities against the HIF-1 alpha enzyme. Compound 9d exhibited strong antiproliferation activity against pancreatic cancer cells and may be a promising lead for further studies.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Vaclav Mandys, Alexey Popov, Robert Gurlich, Jan Havranek, Lucie Pfeiferova, Michal Kolar, Jana Vranova, Karel Smetana Jr, Lukas Lacina, Pavol Szabo
Summary: Therapy for pancreatic ductal adenocarcinoma is challenging and a complete cure is rare. The role of miRNAs in controlling the biological properties of this tumor type has been extensively studied. In this study, the expression of miR-21, -96, -196a, -210, and -217 in different types of cells was compared, revealing significant differences in miRNA expression between cancer-associated fibroblasts and normal tissue. The findings suggest that miR-21 and -210 may play a role in the development of pancreatic cancer and could be potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Lijie Jiang, Tianming Qiu, Xiaofeng Yao, Huangben Chen, Kun Yao, Xiance Sun, Guang Yang, Liping Jiang, Cong Zhang, Ningning Wang, Hongying Zhang, Xiaofang Liu
Summary: Exposure to MEHP induces pyroptosis and upregulates autophagy levels in a CTSB-dependent manner, and autophagy plays an essential role in pyroptosis onset in INS-1 cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Cihan Gur, Fatih Mehmet Kandemir, Cuneyt Caglayan, Emine Satici
Summary: This study found that hesperidin has a protective effect against paclitaxel-induced hepatorenal toxicity by reducing oxidative stress, inflammation, apoptosis, and autophagy, and improving liver and kidney functions.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Huijie Fan, Yanrong Li, Mengying Sun, Wushuai Xiao, Lijuan Song, Qing Wang, Bo Zhang, Jiezhong Yu, Xiaoming Jin, Cungen Ma, Zhi Chai
Summary: Hyperoside has shown neuroprotective effects in rotenone-induced PD rat model and SH-SY5Y cell model by affecting autophagy pathways, providing potential therapeutic benefits for Parkinson's disease treatment.
NEUROCHEMICAL RESEARCH
(2021)
Article
Oncology
Lihui Guo, Bernadette Schurink, Eva Roos, Esther J. Nossent, Jan Willem Duitman, Alexander P. J. Vlaar, Paul van der Valk, Frederic M. Vaz, Syun-Ru Yeh, Zachary Geeraerts, Annemiek Dijkhuis, Lonneke van Vught, Marianna Bugiani, Rene Lutter
Summary: COVID-19 is associated with the accumulation of tryptophan degradation products in the lungs, heart, and brain. The expression of IDO-2, an isoform rarely expressed, is related to cell death and severe cellular stress in these organs. The early activation of the kynurenine/aryl-hydrocarbon receptor/IDO-2 axis may contribute to the pathology of severe COVID-19.
JOURNAL OF PATHOLOGY
(2022)
Article
Plant Sciences
Mutiat Ibrahim, Nutan Kaushik, Abimbola Sowemimo, Hemraj Chhipa, Trevor Koekemoer, Maryna van de Venter, Olukemi A. Odukoya
PHARMACEUTICAL BIOLOGY
(2017)
Article
Neurosciences
R. van Onselen, L. Venables, M. van de Venter, T. G. Downing
NEUROTOXICITY RESEARCH
(2018)
Article
Plant Sciences
G. J. Boukes, T. C. Koekemoer, M. van de Venter, S. Govender
SOUTH AFRICAN JOURNAL OF BOTANY
(2017)
Article
Plant Sciences
O. Eboji, L. Venables, A. A. Sowemimo, M. O. Sofidiya, T. Koekemoer, M. Van de Venter
SOUTH AFRICAN JOURNAL OF BOTANY
(2017)
Article
Integrative & Complementary Medicine
Idowu Jonas Sagbo, Maryna van de Venter, Trevor Koekemoer, Graeme Bradley
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Plant Sciences
Nadine A. Pringle, Trevor C. Koekemoer, Andrea Holzer, Carly Young, Luanne Venables, Maryna van de Venter
Article
Plant Sciences
M. B. Ibrahim, A. A. Sowemimo, L. Venables, Na. Koorbanally, G. V. Awolola, M. O. Sofidiya, O. A. Odukoya, T. Koekemoer, M. van de Venter
SOUTH AFRICAN JOURNAL OF BOTANY
(2018)
Article
Food Science & Technology
Anna C. Hattingh, Maryna van de Venter, Trevor C. Koekemoer
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Biochemistry & Molecular Biology
Bresler Swanepoel, George Mihai Nitulescu, Octavian Tudorel Olaru, Luanne Venables, Maryna van de Venter
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Agriculture, Dairy & Animal Science
Maryna van de Venter, Jenske Didloff, Shanika Reddy, Bresler Swanepoel, Sharlene Govender, Ntokozo Shirley Dambuza, Saralene Williams, Trevor Craig Koekemoer, Luanne Venables
Summary: This review highlights the increasing importance of developing new drugs to treat diabetes and its complications, emphasizing the value of using wild-type zebrafish larvae as a suitable animal model. It discusses organ development in zebrafish larvae and provides an overview of technical aspects in using them for diabetes research, suggesting them as a cost-effective alternative to mutant zebrafish lines.
Article
Chemistry, Multidisciplinary
Babatunde Ayodeji Adeagbo, Akintunde Oluseto Akinlalu, Tony Phan, Jeff Guderian, Gerhardt Boukes, Elize Willenburg, Caryn Fenner, Oluseye Oladotun Bolaji, Christopher B. Fox
Article
Plant Sciences
Nadine A. Pringle, Maryna van de Venter, Gerhardt J. Boukes, Trevor C. Koekemoer
Summary: This study investigated the potential of four wild mushroom species for diabetic wound healing, using various in vitro models to assess antioxidant, collagenase inhibition, immune modulatory capacity, and fibroblast migration. Results showed different macrophage responses to the mushroom species, with the ethanol extract of Russula capensis producing the most favorable effects in attenuating inflammation, promoting macrophage transition, re-establishing phagocytic activity, and stimulating fibroblast cell migration in diabetic wounds.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Plant Sciences
Khumo M. Rampa, Maryna van de Venter, Trevor C. Koekemoer, Bresler Swanepoel, Luanne Venables, Anna C. Hattingh, Alvaro M. Viljoen, Guy P. Kamatou
Summary: The study evaluated the potential anti-inflammatory activity of four South African Croton species extracts and assessed the potential risk for hepatotoxicity and genotoxicity using an in vitro cellomics approach. Research found that while the selected species have anti-inflammatory components, there is a risk for possible hepatotoxic and genotoxic side effects which may limit their prospect for further drug development.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
G. Boukes, J. Didloff, M. van de Venter, S. Govender
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
