A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages

A module for Rac temporal signal integration revealed with optogenetics

(2017) Brian R. Graziano et al.   JOURNAL OF CELL BIOLOGY

The Protein Kinase C Inhibitor Aeb071 (Sotrastaurin) Modulates Migration and Superoxide Anion Production by Human Neutrophils In Vitro

(2017) F. Capsoni et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Regulation of a Coupled MARCKS–PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module

(2016) Brian P. Ziemba et al.   BIOCHEMISTRY

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway

(2016) Brian P. Ziemba et al.   BIOPHYSICAL JOURNAL

Are Filopodia Privileged Signaling Structures in Migrating Cells?

(2016) Heath E. Johnson et al.   BIOPHYSICAL JOURNAL

PI3K signalling in inflammation

(2015) P.T. Hawkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Locally excitable Cdc42 signals steer cells during chemotaxis

(2015) Hee Won Yang et al.   NATURE CELL BIOLOGY

Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux

(2015) Rebecca W. Beerman et al.   Cell Reports

The Role of Phosphoinositide 3-Kinases in Neutrophil Migration in 3D Collagen Gels

(2015) Kayleigh J. S. Martin et al.   PLoS One

Single-Molecule Studies Reveal a Hidden Key Step in the Activation Mechanism of Membrane-Bound Protein Kinase C-α

(2014) Brian P. Ziemba et al.   BIOCHEMISTRY

Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes

(2014) Yulia Artemenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interplay between phosphoinositide lipids and calcium signals at the leading edge of chemotaxing ameboid cells

(2014) Joseph J. Falke et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

(2014) James E Bear et al.   CURRENT OPINION IN CELL BIOLOGY

Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLCγ/PKCα Pathway

(2014) Sreeja B. Asokan et al.   DEVELOPMENTAL CELL

The Directional Response of Chemotactic Cells Depends on a Balance between Cytoskeletal Architecture and the External Gradient

(2014) Ming-Jie Wang et al.   Cell Reports

Purinergic and Calcium Signaling in Macrophage Function and Plasticity

(2014) Bimal N. Desai et al.   Frontiers in Immunology

Molecular players in neutrophil chemotaxis-focus on PI3K and small GTPases

(2013) Laure Gambardella et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mammalian Phospholipase C

(2012) Ganesh Kadamur et al.   Annual Review of Physiology

The membrane binding kinetics of full-length PKCα is determined by membrane lipid composition

(2012) Ángel Pérez-Lara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration

(2012) Hiroki Kawamura et al.   IMMUNOLOGY

Functional Proteomic Analysis of Long-term Growth Factor Stimulation and Receptor Tyrosine Kinase Coactivation in Swiss 3T3 Fibroblasts

(2012) Kohji Nagano et al.   MOLECULAR & CELLULAR PROTEOMICS

Cooperative Activation of PI3K by Ras and Rho Family Small GTPases

(2012) Hee Won Yang et al.   MOLECULAR CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

How Cells Integrate Complex Stimuli: The Effect of Feedback from Phosphoinositides and Cell Shape on Cell Polarization and Motility

(2012) Athanasius F. M. Marée et al.   PLoS Computational Biology

Activation of the PI3K/Akt signaling pathway through P2Y2 receptors by extracellular ATP is involved in osteoblastic cell proliferation

(2011) Sebastián Katz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sequestration of phosphoinositides by mutated MARCKS effector domain inhibits stimulated Ca2+ mobilization and degranulation in mast cells

(2011) Deepti Gadi et al.   MOLECULAR BIOLOGY OF THE CELL

Moving in the right direction: How eukaryotic cells migrate along chemical gradients

(2011) Huaqing Cai et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Eukaryotic Chemotaxis: A Network of Signaling Pathways Controls Motility, Directional Sensing, and Polarity

(2010) Kristen F. Swaney et al.   Annual Review of Biophysics

Membrane Docking Geometry and Target Lipid Stoichiometry of Membrane-Bound PKCα C2 Domain: A Combined Molecular Dynamics and Experimental Study

(2010) Chun-Liang Lai et al.   JOURNAL OF MOLECULAR BIOLOGY

Large-conductance channel formation mediated by P2X7 receptor activation is regulated through distinct intracellular signaling pathways in peritoneal macrophages and 2BH4 cells

(2010) R. X. Faria et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein Regulation of Human Neutrophil Migration

(2009) Rachael E. Eckert et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Effect of PIP2Binding on the Membrane Docking Geometry of PKCα C2 Domain: An EPR Site-Directed Spin-Labeling and Relaxation Study†

(2008) Kyle E. Landgraf et al.   BIOCHEMISTRY

The regulation of cell motility and chemotaxis by phospholipid signaling

(2008) V. Kolsch et al.   JOURNAL OF CELL SCIENCE

Synthetic Activation of Endogenous PI3K and Rac Identifies an AND-Gate Switch for Cell Polarization and Migration

(2008) Takanari Inoue et al.   PLoS One