Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus

A (–)-kolavenyl diphosphate synthase catalyzes the first step of salvinorin A biosynthesis in Salvia divinorum

(2017) Xiaoyue Chen et al.   JOURNAL OF EXPERIMENTAL BOTANY

Labdane diterpene lactones of Vitex pubescens and their antileukemic properties

(2017) Lenny Anwar et al.   MEDICINAL CHEMISTRY RESEARCH

Biosynthesis of the psychotropic plant diterpene salvinorin A: Discovery and characterization of theSalvia divinorumclerodienyl diphosphate synthase

(2017) Kyle A. Pelot et al.   PLANT JOURNAL

Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii

(2017) Irini Pateraki et al.   eLife

Identification of PTP1B and α-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and α-Glucosidase Inhibition Profiling and HPLC-HRMS-SPE-NMR

(2016) Sileshi G. Wubshet et al.   JOURNAL OF NATURAL PRODUCTS

Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis

(2016) Meirong Jia et al.   METABOLIC ENGINEERING

A Review on the Terpenes from Genus Vitex

(2016) Jin-Long Yao et al.   MOLECULES

Integrative Approaches for the Identification and Localization of Specialized Metabolites in Tripterygium Roots

(2016) B. Markus Lange et al.   PLANT PHYSIOLOGY

Oxidation and cyclization of casbene in the biosynthesis ofEuphorbiafactors from mature seeds ofEuphorbia lathyrisL.

(2016) Dan Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carnosic acid biosynthesis elucidated by a synthetic biology platform

(2016) Codruta Ignea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast

(2016) Ulschan Scheler et al.   Nature Communications

Combined metabolome and transcriptome profiling provides new insights into diterpene biosynthesis in S. pomifera glandular trichomes

(2015) Fotini A. Trikka et al.   BMC GENOMICS

Identification of a New Diterpene Biosynthetic Gene Cluster that ProducesO-Methylkolavelool inHerpetosiphon aurantiacus

(2015) Chiaki Nakano et al.   CHEMBIOCHEM

Evaluation of Chemical Composition and Antimicrobial Activity ofVitex agnus castusL. Fruits’ Essential Oils from West Anatolia, Turkey

(2015) Tamer Eryigit et al.   Journal of Essential Oil Bearing Plants

Antibacterial Labdane Diterpenoids from Vitex vestita

(2015) Nina Corlay et al.   JOURNAL OF NATURAL PRODUCTS

Reconstructing the chemical diversity of labdane-type diterpene biosynthesis in yeast

(2015) Codruta Ignea et al.   METABOLIC ENGINEERING

Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones

(2015) Juan Guo et al.   NEW PHYTOLOGIST

Mass spectrometry imaging for plant biology: a review

(2015) Berin A. Boughton et al.   PHYTOCHEMISTRY REVIEWS

Furanoditerpenoids of the Labdane Series: Occurrence in Plants, Total Synthesis, Several Transformations, and Biological Activity

(2014) E. E. Shul′ts et al.   CHEMISTRY OF NATURAL COMPOUNDS

Synthesis and κ-Opioid Receptor Activity of Furan-Substituted Salvinorin A Analogues

(2014) Andrew P. Riley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes

(2014) Kathleen Brückner et al.   PHYTOCHEMISTRY

Diterpene synthases of the biosynthetic system of medicinally active diterpenoids inMarrubium vulgare

(2014) Philipp Zerbe et al.   PLANT JOURNAL

Manoyl Oxide (13R), the Biosynthetic Precursor of Forskolin, Is Synthesized in Specialized Root Cork Cells in Coleus forskohlii

(2014) I. Pateraki et al.   PLANT PHYSIOLOGY

Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia

(2014) Leonidah K. Omosa et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Anti-inflammatory constituents from the fruits of Vitex rotundifolia

(2013) Chul Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EasyClone: method for iterative chromosomal integration of multiple genes inSaccharomyces cerevisiae

(2013) Niels B. Jensen et al.   FEMS YEAST RESEARCH

Labdane-Type Diterpenoids from the Fruits of Vitex trifolia

(2013) Cheng-Jian Zheng et al.   JOURNAL OF NATURAL PRODUCTS

Antimycobacterial Labdane Diterpenes from Leucas stelligera

(2013) Roshan R. Kulkarni et al.   JOURNAL OF NATURAL PRODUCTS

Building Phylogenetic Trees from Molecular Data with MEGA

(2013) B. G. Hall   MOLECULAR BIOLOGY AND EVOLUTION

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis

(2013) Brian J Haas et al.   Nature Protocols

Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae

(2013) Jiachen Zi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

High-level diterpene production by transient expression in Nicotiana benthamiana

(2013) Kathleen Brückner et al.   Plant Methods

Gene Discovery of Modular Diterpene Metabolism in Nonmodel Systems

(2013) P. Zerbe et al.   PLANT PHYSIOLOGY

CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts

(2013) J. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture

(2012) Anne Caniard et al.   BMC PLANT BIOLOGY

Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae

(2012) Codruta Ignea et al.   Microbial Cell Factories

IeCPS2 is potentially involved in the biosynthesis of pharmacologically active Isodon diterpenoids rather than gibberellin

(2012) Jun-Ling Li et al.   PHYTOCHEMISTRY

A New Diterpenoid Glucoside and Two New Diterpenoids from the Fruit of Vitex agnus-castus

(2011) Masateru Ono et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer

(2011) Jonathan Chee Woei Lim et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Domain loss has independently occurred multiple times in plant terpene synthase evolution

(2011) Matthew L. Hillwig et al.   PLANT JOURNAL

The family of terpene synthases in plants: a mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom

(2011) Feng Chen et al.   PLANT JOURNAL

Reconstitution of the Costunolide Biosynthetic Pathway in Yeast and Nicotiana benthamiana

(2011) Qing Liu et al.   PLoS One

Opioidergic mechanisms underlying the actions of Vitex agnus-castus L.

(2010) Donna E. Webster et al.   BIOCHEMICAL PHARMACOLOGY

Terpenoids from Vitex negundo seeds

(2010) Cheng-Jian Zheng et al.   BIOCHEMICAL SYSTEMATICS AND ECOLOGY

Two rings in them all: The labdane-related diterpenoids

(2010) Reuben J. Peters   NATURAL PRODUCT REPORTS

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annuaThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) Keat H. Teoh et al.   Botany

Three New Diterpenoids from the Fruit of Vitex agnus-castus

(2009) Masateru Ono et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Treatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in China

(2009) Zhong He et al.   MATURITAS

Five New Diterpenoids, Viteagnusins A—E, from the Fruit of Vitex agnus-castus

(2008) Masateru Ono et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Phytochemistry and in vitro pharmacological activities of South African Vitex (Verbenaceae) species

(2008) E. Nyiligira et al.   JOURNAL OF ETHNOPHARMACOLOGY

Can VitexAgnus castusBe Used for the Treatment of Mastalgia? What Is the Current Evidence?

(2007) A. R. Carmichael   Evidence-based Complementary and Alternative Medicine