Combined metabolome and transcriptome profiling provides new insights into diterpene biosynthesis in S. pomifera glandular trichomes

Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer

(2015) Radha Munagala et al.   CANCER LETTERS

Redox-dependent induction of antioxidant defenses by phenolic diterpenes confers stress tolerance in normal human skin fibroblasts: Insights on replicative senescence

(2015) Ana C. Carvalho et al.   FREE RADICAL BIOLOGY AND MEDICINE

The prevention and treatment effects of tanshinone IIA on oestrogen/androgen-induced benign prostatic hyperplasia in rats

(2015) Chao Wang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Reconstructing the chemical diversity of labdane-type diterpene biosynthesis in yeast

(2015) Codruta Ignea et al.   METABOLIC ENGINEERING

Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase

(2015) Codruta Ignea et al.   METABOLIC ENGINEERING

The Gymnosperm Cytochrome P450 CYP750B1 Catalyzes Stereospecific Monoterpene Hydroxylation of (+)-Sabinene in Thujone Biosynthesis in Western Redcedar

(2015) Andreas Gesell et al.   PLANT PHYSIOLOGY

Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis

(2015) Dragana Božić et al.   PLoS One

RNA sequencing on Solanum lycopersicum trichomes identifies transcription factors that activate terpene synthase promoters

(2014) Eleni A Spyropoulou et al.   BMC GENOMICS

Next generation sequencing unravels the biosynthetic ability of Spearmint (Mentha spicata) peltate glandular trichomes through comparative transcriptomics

(2014) Jingjing Jin et al.   BMC PLANT BIOLOGY

Tanshinone IIA Promotes Pulmonary Artery Smooth Muscle Cell Apoptosisin Vitroby Inhibiting the JAK2/STAT3 Signaling Pathway

(2014) Minggang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes

(2014) Kathleen Brückner et al.   PHYTOCHEMISTRY

Dual Function of the Cytochrome P450 CYP76 Family from Arabidopsis thaliana in the Metabolism of Monoterpenols and Phenylurea Herbicides

(2014) R. Hofer et al.   PLANT PHYSIOLOGY

Computational Identification and Systematic Classification of Novel Cytochrome P450 Genes in Salvia miltiorrhiza

(2014) Haimei Chen et al.   PLoS One

Investigation of terpene diversification across multiple sequenced plant genomes

(2014) Alexander M. Boutanaev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism

(2014) A. L. Robertson et al.   Science Translational Medicine

Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer

(2013) Wenxing Chen et al.   Anti-Cancer Agents in Medicinal Chemistry

Tanshinone I Activates the Nrf2-Dependent Antioxidant Response and Protects Against As(III)-Induced Lung Inflammation In Vitro and In Vivo

(2013) Shasha Tao et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway

(2013) Justin T. Fischedick et al.   BIOORGANIC & MEDICINAL CHEMISTRY

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae

(2013) Jiachen Zi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Unusual properties of the cytochrome P450 superfamily

(2013) D. C. Lamb et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Plant P450s as versatile drivers for evolution of species-specific chemical diversity

(2013) B. Hamberger et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Transcriptome Analysis of Medicinal Plant Salvia miltiorrhiza and Identification of Genes Related to Tanshinone Biosynthesis

(2013) Lei Yang et al.   PLoS One

CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts

(2013) J. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Burch. ex Benth. (Lamiaceae)

(2013) Tsholofelo A. Mokoka et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Constituents from Salvia Species and Their Biological Activities

(2012) Yi-Bing Wu et al.   CHEMICAL REVIEWS

Tanshinone IIA Protects Against Cardiac Hypertrophy via Inhibiting Calcineurin/Nfatc3 Pathway

(2012) Xueying Tan et al.   International Journal of Biological Sciences

Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza

(2012) Yimian Ma et al.   JOURNAL OF EXPERIMENTAL BOTANY

Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production

(2012) Yongjin J. Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae

(2012) Codruta Ignea et al.   Microbial Cell Factories

Cardiovascular actions and therapeutic potential of tanshinone IIA

(2011) Si Gao et al.   ATHEROSCLEROSIS

Diterpenoid Tanshinones and Phenolic Acids from Cultured Hairy Roots of Salvia miltiorrhiza Bunge and Their Antimicrobial Activities

(2011) Jianglin Zhao et al.   MOLECULES

Full-length transcriptome assembly from RNA-Seq data without a reference genome

(2011) Manfred G Grabherr et al.   NATURE BIOTECHNOLOGY

A P450-centric view of plant evolution

(2011) David Nelson et al.   PLANT JOURNAL

The family of terpene synthases in plants: a mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom

(2011) Feng Chen et al.   PLANT JOURNAL

Two rings in them all: The labdane-related diterpenoids

(2010) Reuben J. Peters   NATURAL PRODUCT REPORTS

Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells

(2010) N. Aburai et al.   PHYTOMEDICINE

Comparative Functional Genomic Analysis of Solanum Glandular Trichome Types

(2010) E. T. McDowell et al.   PLANT PHYSIOLOGY

Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing

(2009) Wei Wang et al.   BMC GENOMICS

Alkaline pH enhances farnesol production by Saccharomyces cerevisiae

(2009) Masayoshi Muramatsu et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

(2009) Wei Gao et al.   ORGANIC LETTERS

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes

(2008) Daniel Poeckel et al.   BIOCHEMICAL PHARMACOLOGY

Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway

(2008) Jeremy J. Johnson et al.   PHARMACEUTICAL RESEARCH