Rhinovirus infection induces distinct transcriptome profiles in polarized human macrophages

Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways

(2017) Christina Draijer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of PIM2 in allergic asthma

(2017) Wei Du et al.   Molecular Medicine Reports

Alternative Macrophage Activation Is Increased in Asthma

(2016) Pierre-Olivier Girodet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Emerging role of microRNAs in regulating macrophage activation and polarization in immune response and inflammation

(2016) Xiao-qin Wu et al.   IMMUNOLOGY

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

(2016) Sudipta Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct macrophage phenotypes in allergic and nonallergic lung inflammation

(2015) Patricia Robbe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages

(2015) Abdullah A. Tarique et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Recruited Alveolar Macrophages, in Response to Airway Epithelial–Derived Monocyte Chemoattractant Protein 1/CCL2, Regulate Airway Inflammation and Remodeling in Allergic Asthma

(2015) Yong Gyu Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response

(2015) Chang Xiao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol

(2015) Emma S. Chambers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

High IFN-γ and low SLPI mark severe asthma in mice and humans

(2015) Mahesh Raundhal et al.   JOURNAL OF CLINICAL INVESTIGATION

Rhinovirus-Induced Macrophage Cytokine Expression Does Not Require Endocytosis or Replication

(2014) Thomas G. Saba et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IL-17-Producing Alveolar Macrophages Mediate Allergic Lung Inflammation Related to Asthma

(2014) C. Song et al.   JOURNAL OF IMMUNOLOGY

CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and Mortality

(2014) K. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Resident Alveolar Macrophages Suppress, whereas Recruited Monocytes Promote, Allergic Lung Inflammation in Murine Models of Asthma

(2014) Zbigniew Zasłona et al.   JOURNAL OF IMMUNOLOGY

Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma

(2014) Jun Hong et al.   RESPIRATORY RESEARCH

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

(2013) J. L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

MicroRNA-17/20a/106a modulate macrophage inflammatory responses through targeting signal-regulatory protein α

(2013) Dihan Zhu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rhinovirus colocalizes with CD68- and CD11b-positive macrophages following experimental infection in humans

(2013) J. Kelley Bentley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Systemic Inflammation Is Associated with Differential Gene Expression and Airway Neutrophilia in Asthma

(2013) Juan-juan Fu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Genome-Wide Association Study for Levels of Total Serum IgE Identifies HLA-C in a Japanese Population

(2013) Yohei Yatagai et al.   PLoS One

Argonaute 2 sustains the gene expression program driving human monocytic differentiation of acute myeloid leukemia cells

(2013) I Iosue et al.   Cell Death & Disease

Macrophage Colony Stimulating Factor and Monocyte Chemoattractant Protein 2 are elevated in intrinsic asthmatics

(2011) Rana Dajani et al.   CYTOKINE

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization

(2011) Julia Winter et al.   RNA Biology

MDA5 and TLR3 Initiate Pro-Inflammatory Signaling Pathways Leading to Rhinovirus-Induced Airways Inflammation and Hyperresponsiveness

(2011) Qiong Wang et al.   PLoS Pathogens

Innate signals from Nod2 block respiratory tolerance and program TH2-driven allergic inflammation

(2010) Wei Duan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

More alternative activation of macrophages in lungs of asthmatic patients

(2010) Barbro N. Melgert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rhinovirus Infection of Allergen-Sensitized and -Challenged Mice Induces Eotaxin Release from Functionally Polarized Macrophages

(2010) D. R. Nagarkar et al.   JOURNAL OF IMMUNOLOGY

Role of viral respiratory infections in asthma and asthma exacerbations

(2010) William W Busse et al.   LANCET

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Haplotypes covering the TNFSF10 gene are associated with bronchial asthma

(2010) Markus Weckmann et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Gene Transcription Changes in Asthmatic Chronic Rhinosinusitis with Nasal Polyps and Comparison to Those in Atopic Dermatitis

(2010) Douglas A. Plager et al.   PLoS One

Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16

(2009) Jennifer P. DeMore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

Human Rhinovirus 1B Exposure Induces Phosphatidylinositol 3-Kinase–dependent Airway Inflammation in Mice

(2008) Dawn C. Newcomb et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MDA5/RIG-I and virus recognition

(2008) Osamu Takeuchi et al.   CURRENT OPINION IN IMMUNOLOGY