Understanding the conformational motions of RCK gating rings

Molecular Determinants of BK Channel Functional Diversity and Functioning

(2017) Ramon Latorre et al.   PHYSIOLOGICAL REVIEWS

Role of an Intersubunit Ca2+ Bridge in Structure and Function of BK Channels

(2016) Alexandre G. Vouga et al.   BIOPHYSICAL JOURNAL

Structural basis for gating the high-conductance Ca2+-activated K+ channel

(2016) Richard K. Hite et al.   NATURE

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

(2016) Xiao Tao et al.   NATURE

MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain

(2016) H. Singh et al.   NEUROSCIENCE

Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ring

(2016) Pablo Miranda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage Dependence of BK Channels Gating Ring Motion Studied by State Dependent FRET

(2015) Pablo Miranda et al.   BIOPHYSICAL JOURNAL

Cryo-electron microscopy structure of the Slo2.2 Na+-activated K+ channel

(2015) Richard K. Hite et al.   NATURE

Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating

(2015) Vivian Gonzalez-Perez et al.   Nature Communications

Recent progress on the structure and function of the TrkH/KtrB ion channel

(2014) Elena J Levin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

BK channel activators and their therapeutic perspectives

(2014) Bo H. Bentzen et al.   Frontiers in Physiology

Phosphorylation of a constitutive serine inhibits BK channel variants containing the alternate exon “SRKR”

(2013) Chris Shelley et al.   JOURNAL OF GENERAL PHYSIOLOGY

Interaction between residues in the Mg2+-binding site regulates BK channel activation

(2013) Junqiu Yang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Ligand-Gating by Ca2+ Is Rate Limiting for Physiological Operation of BKCa Channels

(2013) H. Berkefeld et al.   JOURNAL OF NEUROSCIENCE

The structure of the KtrAB potassium transporter

(2013) Ricardo S. Vieira-Pires et al.   NATURE

Gating of the TrkH ion channel by its associated RCK protein TrkA

(2013) Yu Cao et al.   NATURE

BK channel opening involves side-chain reorientation of multiple deep-pore residues

(2013) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels

(2013) P. Miranda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of allosteric interactions among Ca2+-binding sites in a K+ channel RCK domain

(2013) Frank J. Smith et al.   Nature Communications

The Contribution of RCK Domains to Human BK Channel Allosteric Activation

(2012) Nicoletta Savalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel

(2012) M. D. Leonetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Barium ions selectively activate BK channels via the Ca2+-bowl site

(2012) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BK potassium channel modulation by leucine-rich repeat-containing proteins

(2012) J. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Ba2+-Bound Gating Ring Reveals Elementary Steps in RCK Domain Activation

(2012) Frank J. Smith et al.   STRUCTURE

The BK channel: a vital link between cellular calcium and electrical signaling

(2012) Brad S. Rothberg   Protein & Cell

Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

(2012) Chunguang Kong et al.   eLife

Metal-driven Operation of the Human Large-conductance Voltage- and Ca2+-dependent Potassium Channel (BK) Gating Ring Apparatus

(2011) Anoosh D. Javaherian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel

(2011) Peng Yuan et al.   NATURE

Crystal structure of a potassium ion transporter, TrkH

(2011) Yu Cao et al.   NATURE

Intragenic alternative splicing coordination is essential for Caenorhabditis elegans slo-1 gene function

(2011) D. A. Glauser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domain

(2011) V. P. T. Pau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region

(2011) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternatively spliced domains interact to regulate BK potassium channel gating

(2011) B. E. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric mechanism of Ca2+activation and H+-inhibited gating of the MthK K+channel

(2010) Victor P.T. Pau et al.   JOURNAL OF GENERAL PHYSIOLOGY

The RCK1 domain of the human BKCachannel transduces Ca2+binding into structural rearrangements

(2010) Taleh Yusifov et al.   JOURNAL OF GENERAL PHYSIOLOGY

Modulation of BK Channel Gating by the  2 Subunit Involves Both Membrane-Spanning and Cytoplasmic Domains of Slo1

(2010) U. S. Lee et al.   JOURNAL OF NEUROSCIENCE

Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

(2010) Yunkun Wu et al.   NATURE

Operation of the voltage sensor of a human voltage- and Ca2+-activated K+ channel

(2010) A. Pantazis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ion sensing in the RCK1 domain of BK channels

(2010) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution

(2010) P. Yuan et al.   SCIENCE

BK channel activation: structural and functional insights

(2010) Urvi S. Lee et al.   TRENDS IN NEUROSCIENCES

KTN (RCK) Domains Regulate K+ Channels and Transporters by Controlling the Dimer-Hinge Conformation

(2009) Tarmo P. Roosild et al.   STRUCTURE

Measurements of the BKCaChannel's High-Affinity Ca2+Binding Constants: Effects of Membrane Voltage

(2008) Tara-Beth Sweet et al.   JOURNAL OF GENERAL PHYSIOLOGY

Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains

(2008) Huanghe Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain

(2008) Shangwei Hou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY