Tungstate-Targeting of BKαβ1 Channels Tunes ERK Phosphorylation and Cell Proliferation in Human Vascular Smooth Muscle

BK channel activation by tungstate requires the β1 subunit extracellular loop residues essential to modulate voltage sensor function and channel gating

(2013) Ana I. Fernández-Mariño et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Novel Phenolic Inhibitors of Small/Intermediate-Conductance Ca2+-Activated K+ Channels, KCa3.1 and KCa2.3

(2013) Aida Oliván-Viguera et al.   PLoS One

Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel

(2013) Anirban Banerjee et al.   eLife

Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation

(2012) Ana I. Fernández-Mariño et al.   CARDIOVASCULAR RESEARCH

Heavy metal to lower the pressure?

(2012) R. Kohler   CARDIOVASCULAR RESEARCH

Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins

(2012) Delia Zafra et al.   FEBS LETTERS

Modulation of BK channel voltage gating by different auxiliary   subunits

(2012) G. F. Contreras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating

(2011) Xixi Chen et al.   JOURNAL OF GENERAL PHYSIOLOGY

An extracellular domain of the accessory β1 subunit is required for modulating BK channel voltage sensor and gate

(2011) Aleksandra Gruslova et al.   JOURNAL OF GENERAL PHYSIOLOGY

Calcium-activated K+ channels increase cell proliferation independent of K+ conductance

(2010) Joanne E. Millership et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Characterization of Ion Channels Involved in the Proliferative Response of Femoral Artery Smooth Muscle Cells

(2010) Pilar Cidad et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sodium Tungstate and Vanadyl Sulfate Effects on Blood Pressure and Vascular Prostanoids Production in Fructose-Overloaded Rats

(2010) Horatio A. Peredo et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Proof-of-concept trial on the efficacy of sodium tungstate in human obesity

(2010) F. Hanzu et al.   DIABETES OBESITY & METABOLISM

Sodium tungstate regulates food intake and body weight through activation of the hypothalamic leptin pathway

(2010) M. Amigó-Correig et al.   DIABETES OBESITY & METABOLISM

Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation

(2010) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The glucose-lowering agent sodium tungstate increases the levels and translocation of GLUT4 in L6 myotubes through a mechanism associated with ERK1/2 and MEF2D

(2008) M. D. Girón et al.   DIABETOLOGIA

M2Muscarinic Receptors Induce Airway Smooth Muscle Activation via a Dual, Gβγ-mediated Inhibition of Large Conductance Ca2+-activated K+Channel Activity

(2008) Xiao-Bo Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a New Activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the Endothelium-Derived Hyperpolarizing Factor Response and Lowers Blood Pressure

(2008) A. Sankaranarayanan et al.   MOLECULAR PHARMACOLOGY