Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth

MED12 exon 2 mutations are common in uterine leiomyomas from South African patients

(2015) Netta Mäkinen et al.   Oncotarget

Cell cultures in uterine leiomyomas: Rapid disappearance of cells carryingMED12mutations

(2014) Dominique Nadine Markowski et al.   GENES CHROMOSOMES & CANCER

Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications

(2014) Molly B. Moravek et al.   HUMAN REPRODUCTION UPDATE

MicroRNAs in the development and pathobiology of uterine leiomyomata: does evidence support future strategies for clinical intervention?

(2014) Anatte E. Karmon et al.   HUMAN REPRODUCTION UPDATE

Incidence of Additional Treatments in Women Treated with MR-Guided Focused US for Symptomatic Uterine Fibroids: Review of 138 Patients with an Average Follow-up of 2.8 Years

(2014) Krzysztof R. Gorny et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

Overexpression of the truncated form of High Mobility Group A proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation

(2014) Aymara Mas et al.   MOLECULAR HUMAN REPRODUCTION

Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Müllerian duct mesenchyme-derived myometria

(2014) Tomoko Kaneko-Tarui et al.   MOLECULAR HUMAN REPRODUCTION

Paricalcitol, a Vitamin D Receptor Activator, Inhibits Tumor Formation in a Murine Model of Uterine Fibroids

(2014) Sunil K. Halder et al.   Reproductive Sciences

Cytokine Patterns Differ Seasonally between Women with and without Uterine Leiomyomata

(2013) Ganesa Wegienka et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

World of Reproductive Biology

(2013) Charlotte Schubert   BIOLOGY OF REPRODUCTION

Proteus syndrome review: molecular, clinical, and pathologic features

(2013) M. Michael Cohen   CLINICAL GENETICS

Progesterone Action in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer

(2013) J. Julie Kim et al.   ENDOCRINE REVIEWS

Vitamin D and the Risk of Uterine Fibroids

(2013) Donna Day Baird et al.   EPIDEMIOLOGY

Vaginal mifepristone for the treatment of symptomatic uterine leiomyomata: an open-label study

(2013) Gil M. Yerushalmi et al.   FERTILITY AND STERILITY

Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages

(2013) Andrzej Plewka et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

The associations between the Val158Met in the catechol-O-methyltransferase (COMT) gene and the risk of uterine leiomyoma (ULM)

(2013) Yi Feng et al.   GENE

Signalling pathways in succinate dehydrogenase B-associated renal carcinoma

(2013) Stewart Fleming et al.   HISTOPATHOLOGY

Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity

(2013) Marieke A. de Graaff et al.   HUMAN PATHOLOGY

MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors

(2013) Katherine E. Schwetye et al.   HUMAN PATHOLOGY

The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy

(2013) Reshef Tal et al.   HUMAN REPRODUCTION UPDATE

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Vitamin D Status in Women With Uterine Leiomyomas

(2013) Alessio Paffoni et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Uterine-Specific Loss of Tsc2 Leads to Myometrial Tumors in Both the Uterus and Lungs

(2013) Hen Prizant et al.   MOLECULAR ENDOCRINOLOGY

Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice

(2013) T. Daikoku et al.   MOLECULAR HUMAN REPRODUCTION

Clonality of smooth muscle and fibroblast cell populations isolated from human fibroid and myometrial tissues

(2013) Sarah J. Holdsworth-Carson et al.   MOLECULAR HUMAN REPRODUCTION

The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells

(2013) Michael R. Copley et al.   NATURE CELL BIOLOGY

Uterine Fibroids

(2013) Serdar E. Bulun   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of Uterine Leiomyomas by Whole-Genome Sequencing

(2013) Miika Mehine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Paracrine activation of WNT/ -catenin pathway in uterine leiomyoma stem cells promotes tumor growth

(2013) M. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway

(2013) B. V. Varghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Racial and Ethnic Differences in the Pathogenesis and Clinical Manifestations of Uterine Leiomyoma

(2013) William Catherino et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Racial and Ethnic Health Disparities in Reproductive Medicine: An Evidence-Based Overview

(2013) Carter Owen et al.   SEMINARS IN REPRODUCTIVE MEDICINE

African Ancestry and Genetic Risk for Uterine Leiomyomata

(2012) L. A. Wise et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Germline PIK3CA and AKT1 Mutations in Cowden and Cowden-like Syndromes

(2012) Mohammed S. Orloff et al.   AMERICAN JOURNAL OF HUMAN GENETICS

World of Reproductive Biology

(2012) Charlotte Schubert   BIOLOGY OF REPRODUCTION

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia

(2012) M. E. McNerney et al.   BLOOD

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer

(2012) K Kämpjärvi et al.   BRITISH JOURNAL OF CANCER

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

(2012) Sidong Huang et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Cutl1: A potential target for cancer therapy

(2012) Kuan-can Liu et al.   CELLULAR SIGNALLING

Treatment of uterine myoma with 5 or 10mg mifepristone daily during 6 months, post-treatment evolution over 12 months: double-blind randomised clinical trial

(2012) Josep Ll. Carbonell Esteve et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Identification and characterization of the human leiomyoma side population as putative tumor-initiating cells

(2012) Aymara Mas et al.   FERTILITY AND STERILITY

A novel mouse model that closely mimics human uterine leiomyomas

(2012) Michael Drosch et al.   FERTILITY AND STERILITY

CUX1 transcription factors: From biochemical activities and cell-based assays to mouse models and human diseases

(2012) Laura Hulea et al.   GENE

MED12mutations occurring in benign and malignant mammalian smooth muscle tumors

(2012) Dominique Nadine Markowski et al.   GENES CHROMOSOMES & CANCER

Identification ofCUX1as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma

(2012) Eric F. P. M. Schoenmakers et al.   GENES CHROMOSOMES & CANCER

Recent developments in uterine mesenchymal neoplasms

(2012) Sarah Chiang et al.   HISTOPATHOLOGY

Prevalence ofMED12mutations in uterine and extrauterine smooth muscle tumours

(2012) Akiko Matsubara et al.   HISTOPATHOLOGY

Expression profiling of uterine leiomyomata cytogenetic subgroups reveals distinct signatures in matched myometrium: transcriptional profiling of the t(12;14) and evidence in support of predisposing genetic heterogeneity

(2012) Jennelle C. Hodge et al.   HUMAN MOLECULAR GENETICS

MED12 mutations in uterine fibroids-their relationship to cytogenetic subgroups

(2012) Dominique Nadine Markowski et al.   INTERNATIONAL JOURNAL OF CANCER

Succinate Dehydrogenase Kidney Cancer: An Aggressive Example of the Warburg Effect in Cancer

(2012) Christopher J. Ricketts et al.   JOURNAL OF UROLOGY

Are uterine leiomyoma a consequence of a chronically inflammatory immune system?

(2012) Ganesa Wegienka   MEDICAL HYPOTHESES

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma

(2012) Gloria Ravegnini et al.   MODERN PATHOLOGY

Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism

(2012) C. Bardella et al.   MOLECULAR AND CELLULAR BIOLOGY

Ulipristal Acetate versus Placebo for Fibroid Treatment before Surgery

(2012) Jacques Donnez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ulipristal Acetate versus Leuprolide Acetate for Uterine Fibroids

(2012) Jacques Donnez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Homologous recombination and its regulation

(2012) L. Krejci et al.   NUCLEIC ACIDS RESEARCH

An update on the pathomechanisms and future therapies of Alport syndrome

(2012) Damien Noone et al.   PEDIATRIC NEPHROLOGY

Whole Exome Sequencing in a Random Sample of North American Women with Leiomyomas Identifies MED12 Mutations in Majority of Uterine Leiomyomas

(2012) Megan M. McGuire et al.   PLoS One

MED12 Alterations in Both Human Benign and Malignant Uterine Soft Tissue Tumors

(2012) Gaëlle Pérot et al.   PLoS One

Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death

(2012) K.-M. Noh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fumarate hydratase inactivation in renal tumors: HIF1 alpha, NRF2, and "cryptic targets" of transcription factors

(2012) Aikseng Ooi et al.   Chinese Journal of Cancer

The estimated annual cost of uterine leiomyomata in the United States

(2011) Eden R. Cardozo et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCFβ-TRCP in neuroblastoma cells

(2011) Akanksha Singh et al.   CANCER

Deletion of Tuberous Sclerosis 1 in Somatic Cells of the Murine Reproductive Tract Causes Female Infertility

(2011) Yoshihiro Tanaka et al.   ENDOCRINOLOGY

Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications

(2011) Pasquapina Ciarmela et al.   HUMAN REPRODUCTION UPDATE

Predicting PTEN mutations: an evaluation of Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome clinical features

(2011) R. Pilarski et al.   JOURNAL OF MEDICAL GENETICS

The role of progesterone signaling in the pathogenesis of uterine leiomyoma

(2011) J. Julie Kim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Mosaic Activating Mutation inAKT1Associated with the Proteus Syndrome

(2011) Marjorie J. Lindhurst et al.   NEW ENGLAND JOURNAL OF MEDICINE

MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas

(2011) N. Makinen et al.   SCIENCE

Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling

(2010) P. P. Rocha et al.   DEVELOPMENT

Progesterone Is Essential for Maintenance and Growth of Uterine Leiomyoma

(2010) Hiroshi Ishikawa et al.   ENDOCRINOLOGY

Solitary and multiple uterine leiomyomas among Caucasian women: two different disorders?

(2010) Maja Pakiz et al.   FERTILITY AND STERILITY

Pregnancy-related fibroid reduction

(2010) Shannon K. Laughlin et al.   FERTILITY AND STERILITY

Reproductive characteristics and risk of uterine leiomyomata

(2010) Kathryn L. Terry et al.   FERTILITY AND STERILITY

Increased expression of tuberin in human uterine leiomyoma

(2010) Lihua Cui et al.   FERTILITY AND STERILITY

Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase

(2010) Chakradhari Sharan et al.   FERTILITY AND STERILITY

CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer

(2010) S. Ripka et al.   GUT

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism

(2010) Linda O'Flaherty et al.   HUMAN MOLECULAR GENETICS

HMGA proteins regulate the expression of FGF2 in uterine fibroids

(2010) B. M. Helmke et al.   MOLECULAR HUMAN REPRODUCTION

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

Mifepristone for the Treatment of Uterine Leiomyomas

(2010) Josep Lluis Carbonell Esteve et al.   OBSTETRICS AND GYNECOLOGY

Establishment of a Novel Xenograft Model for Human Uterine Leiomyoma in Immunodeficient Mice

(2010) Kenji Tsuiji et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

ORIGINAL ARTICLE: Uterine Leiomyoma is Associated with a Polymorphism in the Interleukin 1-β Gene

(2009) Detlef Pietrowski et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Low-dose mifepristone in treatment of uterine leiomyoma: A randomised double-blind placebo-controlled clinical trial

(2009) Madhu BAGARIA et al.   AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

Constitutive Activation of Beta-Catenin in Uterine Stroma and Smooth Muscle Leads to the Development of Mesenchymal Tumors in Mice1

(2009) Pradeep S. Tanwar et al.   BIOLOGY OF REPRODUCTION

Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway

(2009) J. S. Crabtree et al.   CANCER RESEARCH

Open-label study of ultra low-dose mifepristone for the treatment of uterine leiomyomata

(2009) Steve H. Eisinger et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Mifepristone for treatment of uterine leiomyoma. A prospective randomized placebo controlled trial

(2009) M. Engman et al.   HUMAN REPRODUCTION

High Aromatase Expression in Uterine Leiomyoma Tissues of African-American Women

(2009) Hiroshi Ishikawa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Uterine Leiomyomas Exhibit Fewer Stem/Progenitor Cell Characteristics When Compared With Corresponding Normal Myometrium

(2009) Henry L. Chang et al.   Reproductive Sciences

Murine Xenograft Model for Human Uterine Fibroids: An In Vivo Imaging Approach

(2009) Guangli Suo et al.   Reproductive Sciences

The High Mobility Group Protein HMGA2: A Co-Regulator of Chromatin Structure and Pluripotency in Stem Cells?

(2009) Kurt Pfannkuche et al.   Stem Cell Reviews and Reports

Multi- and Inter-Disciplinary Science in Personalized Delivery of Stem Cells for Tissue Repair

(2009) Andrew Heinrich et al.   Current Stem Cell Research & Therapy

Memy I: a novel murine model for uterine leiomyoma using adenovirus-enhanced human fibroid explants in severe combined immune deficiency mice

(2008) Memy H. Hassan et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

How Much REST Is Enough?

(2008) Allan M. Weissman   CANCER CELL

Lack of Hypoxic Response in Uterine Leiomyomas despite Severe Tissue Hypoxia

(2008) A. Mayer et al.   CANCER RESEARCH

Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression

(2008) Jinsuke Nishino et al.   CELL

Vitamin D inhibits myometrial and leiomyoma cell proliferation in vitro

(2008) Merja Bläuer et al.   FERTILITY AND STERILITY

The multiple roles of CUX1: Insights from mouse models and cell-based assays

(2008) Laurent Sansregret et al.   GENE

Association of theCYP17gene polymorphism with risk for uterine leiomyoma in Brazilian women

(2008) Lucinda Coelho Esperança Vieira et al.   GYNECOLOGICAL ENDOCRINOLOGY

Tuberous sclerosis

(2008) Paolo Curatolo et al.   LANCET

The catechol-O-methyltransferase (COMT) gene polymorphism and prevalence of uterine fibroids

(2008) Emerson de Oliveira et al.   MATURITAS

Antiproliferative Effects by Let-7 Repression of High-Mobility Group A2 in Uterine Leiomyoma

(2008) Y. Peng et al.   MOLECULAR CANCER RESEARCH

Mediator Links Epigenetic Silencing of Neuronal Gene Expression with X-Linked Mental Retardation

(2008) Ning Ding et al.   MOLECULAR CELL

A mesenchymal perspective of müllerian duct differentiation and regression inAmhr2-lacZ mice

(2008) Nelson A. Arango et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

(2008) Thomas F. Westbrook et al.   NATURE

Control of chromosome stability by the β-TrCP–REST–Mad2 axis

(2008) Daniele Guardavaccaro et al.   NATURE

Growth of uterine leiomyomata among premenopausal black and white women

(2008) S. D. Peddada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells

(2008) Julie Douville et al.   STEM CELLS AND DEVELOPMENT