Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1

(2012) Pradeep S. Tanwar et al.   PLoS Genetics

Deletion of Tuberous Sclerosis 1 in Somatic Cells of the Murine Reproductive Tract Causes Female Infertility

(2011) Yoshihiro Tanaka et al.   ENDOCRINOLOGY

Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes

(2011) Takiko Daikoku et al.   GYNECOLOGIC ONCOLOGY

Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice

(2011) Y. Hirota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of inhibitory insulin receptor substrate-1 phosphorylation: An early event in endometrial hyperplasia and progression to carcinoma

(2010) Adrienne S. McCampbell et al.   CELL CYCLE

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

(2010) C. M. Contreras et al.   Disease Models & Mechanisms

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium

(2010) S. Memarzadeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

(2009) D. Adhikari et al.   HUMAN MOLECULAR GENETICS

Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles

(2009) D. Adhikari et al.   MOLECULAR HUMAN REPRODUCTION

Genetic Loss of Faah Compromises Male Fertility in Mice1

(2008) Xiaofei Sun et al.   BIOLOGY OF REPRODUCTION

Conditional Loss of Uterine Pten Unfailingly and Rapidly Induces Endometrial Cancer in Mice

(2008) T. Daikoku et al.   CANCER RESEARCH

Loss of Tuberous Sclerosis Complex-2 Function and Activation of Mammalian Target of Rapamycin Signaling in Endometrial Carcinoma

(2008) K. H. Lu et al.   CLINICAL CANCER RESEARCH

Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to rapamycin treatment in vitro

(2008) Silvia Darb-Esfahani et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Tuberous sclerosis

(2008) Paolo Curatolo et al.   LANCET

Targeted Disruption ofPtenin Ovarian Granulosa Cells Enhances Ovulation and Extends the Life Span of Luteal Cells

(2008) Heng-Yu Fan et al.   MOLECULAR ENDOCRINOLOGY

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

(2008) P. Reddy et al.   SCIENCE