The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells
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Title
The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells
Authors
Keywords
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Journal
NATURE CELL BIOLOGY
Volume 15, Issue 8, Pages 916-925
Publisher
Springer Nature
Online
2013-06-28
DOI
10.1038/ncb2783
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- Lin28b Reprograms Adult Bone Marrow Hematopoietic Progenitors to Mediate Fetal-Like Lymphopoiesis
- (2012) Joan Yuan et al. SCIENCE
- 3'UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice
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- Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells
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- Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria
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- Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms
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- The 12q14 microdeletion syndrome: six new cases confirming the role of HMGA2 in growth
- (2011) Sally Ann Lynch et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial
- (2010) G. P. Wang et al. BLOOD
- Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia
- (2010) Marina Cavazzana-Calvo et al. NATURE
- Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential
- (2009) D. G. Kent et al. BLOOD
- Refinement of the 12q14 microdeletion syndrome: primordial dwarfism and developmental delay with or without osteopoikilosis
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- ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
- (2009) Yifang Hu et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression
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- The Emergence of Hematopoietic Stem Cells Is Initiated in the Placental Vasculature in the Absence of Circulation
- (2008) Katrin E. Rhodes et al. Cell Stem Cell
- Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28
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- Selective Blockade of MicroRNA Processing by Lin28
- (2008) S. R. Viswanathan et al. SCIENCE
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