Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing

Mitochondrial ROS production correlates with, but does not directly regulate lifespan in drosophila

(2016) Alberto Sanz et al.   Aging-US

How the mitochondrion was shaped by radical differences in substrates

(2014) Dave Speijer   BIOESSAYS

Leigh syndrome: the genetic heterogeneity story continues

(2014) Mike Gerards   BRAIN

Engineering the alternative oxidase gene to better understand and counteract mitochondrial defects: state of the art and perspectives

(2014) Riyad El-Khoury et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intronic and plasmid-derived regions contribute to the large mitochondrial genome sizes of Agaricomycetes

(2014) Kajsa Himmelstrand et al.   CURRENT GENETICS

Mitochondrial DNA disease—molecular insights and potential routes to a cure

(2014) Oliver Russell et al.   EXPERIMENTAL CELL RESEARCH

High Variability of Mitochondrial Gene Order among Fungi

(2014) Gabriela Aguileta et al.   Genome Biology and Evolution

Mitochondrial myopathy, lactic acidosis, and sideroblastic anemia (MLASA) plus associated with a novel de novo mutation (m.8969G>A) in the mitochondrial encoded ATP6 gene

(2014) Lindsay C. Burrage et al.   MOLECULAR GENETICS AND METABOLISM

Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant

(2014) Jahda H Hill et al.   NATURE GENETICS

Transmission of mitochondrial mutations and action of purifying selection in Drosophila melanogaster

(2014) Hansong Ma et al.   NATURE GENETICS

Regular bottlenecks and restrictions to somatic fusion prevent the accumulation of mitochondrial defects in Neurospora

(2014) E. Bastiaans et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

How to deal with oxygen radicals stemming from mitochondrial fatty acid oxidation

(2014) D. Speijer et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mitonuclear interactions: evolutionary consequences over multiple biological scales

(2014) J. N. Wolff et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Relationship between mitochondrial DNA Copy Number and SIRT1 Expression in Porcine Oocytes

(2014) Daichi Sato et al.   PLoS One

Phylogenomic Reconstruction Indicates Mitochondrial Ancestor Was an Energy Parasite

(2014) Zhang Wang et al.   PLoS One

Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals

(2014) K. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

(2014) Laura C. Greaves et al.   PLoS Genetics

The Challenges of Mitochondrial Replacement

(2014) Patrick F. Chinnery et al.   PLoS Genetics

Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System: Implications for Health, Fitness, and Fertility

(2014) Won-Hee Song et al.   Biomed Research International

Maternal inheritance of mitochondrial DNA by diverse mechanisms to eliminate paternal mitochondrial DNA

(2013) Miyuki Sato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The power of yeast to model diseases of the powerhouse of the cell

(2013) Steven Claypool   Frontiers in Bioscience-Landmark

Plant Mitochondrial Genome Evolution Can Be Explained by DNA Repair Mechanisms

(2013) Alan C. Christensen   Genome Biology and Evolution

Mutation dependance of the mitochondrial DNA copy number in the first stages of human embryogenesis

(2013) Sophie Monnot et al.   HUMAN MOLECULAR GENETICS

Embryo developmental capability and pregnancy outcome are related to the mitochondrial DNA copy number and ooplasmic volume

(2013) Yukitaka Murakoshi et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Very Low-Level Heteroplasmy mtDNA Variations Are Inherited in Humans

(2013) Yan Guo et al.   Journal of Genetics and Genomics

Preimplantation genetic diagnosis in mitochondrial DNA disorders: challenge and success

(2013) Suzanne C E H Sallevelt et al.   JOURNAL OF MEDICAL GENETICS

Resveratrol Improves the Mitochondrial Function and Fertilization Outcome of Bovine Oocytes

(2013) Shun TAKEO et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

The activity and copy number of mitochondrial DNA in ovine oocytes throughout oogenesis in vivo and during oocyte maturation in vitro

(2013) Matthew Cotterill et al.   MOLECULAR HUMAN REPRODUCTION

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

(2013) Sandra R Bacman et al.   NATURE MEDICINE

No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline

(2013) E. Hagstrom et al.   NUCLEIC ACIDS RESEARCH

New rRNA Gene-Based Phylogenies of the Alphaproteobacteria Provide Perspective on Major Groups, Mitochondrial Ancestry and Phylogenetic Instability

(2013) Matteo P. Ferla et al.   PLoS One

Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup

(2013) Kevin A. Strauss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria functionality and sperm quality

(2013) Alexandra Amaral et al.   REPRODUCTION

Preventing the transmission of mitochondrial DNA disorders: selecting the good guys or kicking out the bad guys

(2013) Hubert J.M. Smeets   REPRODUCTIVE BIOMEDICINE ONLINE

Mitochondrial Replacement, Evolution, and the Clinic

(2013) K. Reinhardt et al.   SCIENCE

HIV Treatment and Associated Mitochondrial Pathology

(2013) Kristian Gardner et al.   TOXICOLOGIC PATHOLOGY

Patient-derived fibroblasts indicate oxidative stress status and may justify antioxidant therapy in OXPHOS disorders

(2012) A.M. Voets et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Loss, replacement and gain of proteins at the origin of the mitochondria

(2012) Martijn A. Huynen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Dynamic Mutation-Selection Balance as an Evolutionary Attractor

(2012) S. Goyal et al.   GENETICS

Universal heteroplasmy of human mitochondrial DNA

(2012) B. A. I. Payne et al.   HUMAN MOLECULAR GENETICS

Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes

(2012) X.-H. Ou et al.   HUMAN REPRODUCTION

PGD and heteroplasmic mitochondrial DNA point mutations: a systematic review estimating the chance of healthy offspring

(2012) D.M.E.I. Hellebrekers et al.   HUMAN REPRODUCTION UPDATE

Epigenetics, epidemiology and mitochondrial DNA diseases

(2012) Patrick F Chinnery et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Evidence for Compensatory Evolution of Ribosomal Proteins in Response to Rapid Divergence of Mitochondrial rRNA

(2012) F. S. Barreto et al.   MOLECULAR BIOLOGY AND EVOLUTION

Effects of Hoechst 33342 staining and ultraviolet irradiation on mitochondrial distribution and DNA copy number in porcine oocytes and preimplantation embryos

(2012) Maria Antonia Gil et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

The importance of mitochondrial metabolic activity and mitochondrial DNA replication during oocyte maturation in vitro on oocyte quality and subsequent embryo developmental competence

(2012) Hongshan Ge et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Towards germline gene therapy of inherited mitochondrial diseases

(2012) Masahito Tachibana et al.   NATURE

Genetic Counseling in Mitochondrial Disease

(2012) Jodie M. Vento et al.   Neurotherapeutics

The quality of porcine oocytes is affected by sexual maturity of the donor gilt

(2012) Piotr Pawlak et al.   Reproductive Biology

Regulation of oocyte mitochondrial DNA copy number by follicular fluid, EGF, and neuregulin 1 during in vitro maturation affects embryo development in pigs

(2012) J. Mao et al.   THERIOGENOLOGY

Mitochondrial Evolution

(2012) M. W. Gray   Cold Spring Harbor Perspectives in Biology

Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis

(2011) Jaime I Davila et al.   BMC BIOLOGY

The intriguing evolutionary dynamics of plant mitochondrial DNA

(2011) Nicolas Galtier   BMC BIOLOGY

The association of reproductive senescence with mitochondrial quantity, function, and DNA integrity in human oocytes at different stages of maturation

(2011) Hakan E. Duran et al.   FERTILITY AND STERILITY

Mitochondrial DNA disease: new options for prevention

(2011) L. Craven et al.   HUMAN MOLECULAR GENETICS

Mitophagy Plays an Essential Role in Reducing Mitochondrial Production of Reactive Oxygen Species and Mutation of Mitochondrial DNA by Maintaining Mitochondrial Quantity and Quality in Yeast

(2011) Yusuke Kurihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

(2011) Liliane Glauser et al.   JOURNAL OF NEUROCHEMISTRY

Large scale mtDNA sequencing reveals sequence and functional conservation as major determinants of homoplasmic mtDNA variant distribution

(2011) A.M. Voets et al.   MITOCHONDRION

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations

(2011) Brendan A I Payne et al.   NATURE GENETICS

The Strength and Timing of the Mitochondrial Bottleneck in Salmon Suggests a Conserved Mechanism in Vertebrates

(2011) Jonci N. Wolff et al.   PLoS One

Effect of maternal age on mitochondrial DNA copy number, ATP content and IVF outcome of bovine oocytes

(2011) Hisataka Iwata et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Experimental Evidence Supports a Sex-Specific Selective Sieve in Mitochondrial Genome Evolution

(2011) P. Innocenti et al.   SCIENCE

Cytoskeleton proteins F-actin and tubulin distribution and interaction with mitochondria in the granulosa cells surrounding stage III zebrafish (Danio rerio) oocytes

(2011) T. Zampolla et al.   THERIOGENOLOGY

Mediating effect of ROS on mtDNA damage and low ATP content induced by arsenic trioxide in mouse oocytes

(2011) Wenya Zhang et al.   TOXICOLOGY IN VITRO

Evolution Meets Disease: Penetrance and Functional Epistasis of Mitochondrial tRNA Mutations

(2011) Raquel Moreno-Loshuertos et al.   PLoS Genetics

The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1

(2010) Timothy Wai et al.   BIOLOGY OF REPRODUCTION

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Muller's Ratchet and the Degeneration of the Drosophila miranda Neo-Y Chromosome

(2010) V. B. Kaiser et al.   GENETICS

Effect of maternal age on the developmental competence and progression of nuclear maturation in bovine oocytes

(2010) T. Yamamoto et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

(2010) Lyndsey Craven et al.   NATURE

The energetics of genome complexity

(2010) Nick Lane et al.   NATURE

Recombination and the maintenance of plant organelle genome stability

(2010) Alexandre Maréchal et al.   NEW PHYTOLOGIST

Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?

(2010) Ester Perales-Clemente et al.   NUCLEIC ACIDS RESEARCH

Fewer genes than organelles: extremely low and variable gene copy numbers in mitochondria of somatic plant cells

(2010) Tobias Preuten et al.   PLANT JOURNAL

Ooplast-mediated developmental rescue of bovine oocytes exposed to ethidium bromide

(2010) Marcos Roberto Chiaratti et al.   REPRODUCTIVE BIOMEDICINE ONLINE

The origin and early evolution of eukaryotes in the light of phylogenomics

(2010) Eugene V Koonin   GENOME BIOLOGY

Production of Reactive Oxygen Species Is Turned On and Rapidly Shut Down in Epithelial Cells Infected with Chlamydia trachomatis

(2009) G. Boncompain et al.   INFECTION AND IMMUNITY

An Ancient Fission of Mitochondrial cox1

(2009) R. M.R. Gawryluk et al.   MOLECULAR BIOLOGY AND EVOLUTION

Maternal Diabetes Causes Mitochondrial Dysfunction and Meiotic Defects in Murine Oocytes

(2009) Qiang Wang et al.   MOLECULAR ENDOCRINOLOGY

Alternative oxidase: a target and regulator of stress responses

(2009) Olivier Van Aken et al.   PHYSIOLOGIA PLANTARUM

Mutational Meltdown in Primary Endosymbionts: Selection Limits Muller's Ratchet

(2009) Julie M. Allen et al.   PLoS One

Pathogenic Mitochondrial DNA Mutations Are Common in the General Population

(2008) Hannah R. Elliott et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The crucial role of plant mitochondria in orchestrating drought tolerance

(2008) Owen K. Atkin et al.   ANNALS OF BOTANY

Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution

(2008) Dana K Howe et al.   BMC EVOLUTIONARY BIOLOGY

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mitochondrial DNA integrity and copy number in sperm from infertile men

(2008) Gyun Jee Song et al.   FERTILITY AND STERILITY

In vitro–matured rat oocytes have low mitochondrial deoxyribonucleic acid and adenosine triphosphate contents and have abnormal mitochondrial redistribution

(2008) Hai-tao Zeng et al.   FERTILITY AND STERILITY

The Temporal Dynamics of Processes Underlying Y Chromosome Degeneration

(2008) D. Bachtrog   GENETICS

Lost in the zygote: the dilution of paternal mtDNA upon fertilization

(2008) J N Wolff et al.   HEREDITY

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

(2008) Timothy Wai et al.   NATURE GENETICS

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

(2008) Lynsey M Cree et al.   NATURE GENETICS

Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease

(2008) James Bruce Stewart et al.   NATURE REVIEWS GENETICS

Genetic Evidence for a Mitochondriate Ancestry in the ‘Amitochondriate’ Flagellate Trimastix pyriformis

(2008) Vladimir Hampl et al.   PLoS One

Sidestepping Mutational Meltdown

(2008) Eric A. Shoubridge et al.   SCIENCE

A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

(2008) Weiwei Fan et al.   SCIENCE

Evolutionary implications of non-neutral mitochondrial genetic variation

(2008) D DOWLING et al.   TRENDS IN ECOLOGY & EVOLUTION

Mitigating Mutational Meltdown in Mammalian Mitochondria

(2008) David M Rand   PLOS BIOLOGY

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

(2008) James Bruce Stewart et al.   PLOS BIOLOGY