Article
Anatomy & Morphology
A. F. Ogundola, R. E. Akhigbe, W. A. Saka, A. O. Adeniyi, O. S. Adeshina, D. O. Babalola, T. M. Akhigbe
Summary: Andrographis paniculata may induce reproductive toxicity by suppressing testosterone rather than inducing oxidative stress, suggesting its potential as a male contraceptive.
Article
Plant Sciences
Samah A. El-Newary, Mohamed S. Aly, Amal R. Abd El Hameed, Mohamed S. Kotp, Abdelghany A. Youssef, Naglaa A. Ali
Summary: This study investigates the effect of Cordia fresh fruits hydroethanolic extract on fertility in male rats. The results show that the extract significantly reduces sperm count and motility, and has adverse effects on hormone levels and testicular histopathology. Fortunately, these effects recover after stopping administration for one month.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seun Funmilola Akomolafe, Babatunde Aina, Jumoke Bajulaye, Iyadunni Ogundare, Damola Olulade, Rebecca Adeniji, Faith Fatuase, Ayomide Olojo-Kosoko, Oboh Ganiyu, Nnaemeka Tobechukwu Asogwa
Summary: The combination of cashew nut supplemented diet and clomiphene citrate significantly improved testosterone levels, epididymal sperm count, viability, and motility in male rats. It also increased antioxidant capacity and decreased reactive oxygen species levels without observable histopathologic changes in the testes. This finding supports the potential use of cashew nut and clomiphene citrate combination therapy for male infertility.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Qinrui Liu, Hu Wang, Hualin Wang, Na Li, Ruyi He, Zhiguo Liu
Summary: This study found that disruption of the Per1/Per2 genes can decrease the reproductive capacity of elderly male mice. The mechanism involves the reduction of testosterone synthesis and sperm motility through the PKA-StAR pathway, leading to decreased fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Urology & Nephrology
Daniel E. Nassau, Jordan C. Best, Eliyahu Kresch, Daniel C. Gonzalez, Kajal Khodamoradi, Ranjith Ramasamy
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has disproportionately affected men, with androgens potentially playing a role in more severe disease. However, there are still many unanswered questions regarding the specific mechanisms by which COVID-19 impacts male reproductive organs and the long-term consequences on male reproductive health.
Article
Pharmacology & Pharmacy
Farah Hanan Fathihah Jaffar, Khairul Osman, Chua Kien Hui, Aini Farzana Zulkefli, Siti Fatimah Ibrahim
Summary: The study found that supplementation with 250 mg/kg BW/d of EBN showed a significant increase in sperm concentration, sperm motility, FSH, and LH levels compared to the group receiving 10 mg/kg BW/d. There was a dose-dependent increase in testosterone level, but it was not significant between groups. In conclusion, EBN was found to have significant effects on male reproductive parameters.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Physiology
Sofwatul Mokhtarah Maluin, Khairul Osman, Farah Hanan Fathihah Jaffar, Siti Fatimah Ibrahim
Summary: Exposure to radiofrequency electromagnetic radiation from mobile phones and Wi-Fi devices can have negative effects on male reproductive hormones, potentially leading to a reduction in testosterone levels. However, the impact on gonadotrophic hormones is still inconclusive, with studies showing conflicting results influenced by various factors such as energy absorption and duration of device use. Therefore, limiting the use of wireless devices is recommended to minimize potential risks to male reproductive function.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Obstetrics & Gynecology
R. John Aitken
Summary: In modern post-transition societies, delayed reproduction and increased lifespan are observed. The impact of age on female reproduction has been extensively studied, however, the relationship between age and male reproduction is less known. It is now understood that male fertility declines with advancing age, accompanied by reduced testosterone levels, age-dependent reproductive pathologies, and increased sperm DNA damage. Age-related effects in males also result in an elevated disease burden in offspring, including genetic diseases and neuropsychiatric conditions. The underlying genetic mechanisms involve positive selection of stem cells containing mutations and increased oxidative stress which impairs reproductive function. Antioxidants may play a role in managing age-related effects on male reproduction, although clinical trials are needed.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Trine Holm Johannsen, Jakob Albrethsen, Vassos Neocleous, Federico Baronio, Martine Cools, Lise Aksglaede, Niels Jorgensen, Peter Christiansen, Meropi Toumba, Pavlos Fanis, Marie Lindhardt Ljubicic, Anders Juul
Summary: Congenital adrenal hyperplasia (CAH) is a recessive condition that affects the adrenal glands. Adult males with CAH, despite hormone replacement therapy, exhibit reduced levels of Leydig and Sertoli cell-derived hormones, including insulin-like factor 3 (INSL3) and testosterone. This study suggests that circulating INSL3 may serve as a biomarker to monitor Leydig cell function in CAH patients, particularly those with testicular adrenal rest tumors.
ENDOCRINE CONNECTIONS
(2023)
Article
Biochemistry & Molecular Biology
Kunhong Xie, Yan Li, Guoru He, Xuefeng Zhao, Daiwen Chen, Bing Yu, Yuheng Luo, Xiangbing Mao, Zhiqing Huang, Jie Yu, Junqiu Luo, Ping Zheng, Hui Yan, Hua Li, Jun He
Summary: The supplementation of daidzein in sows has been found to improve fertility and ovarian characteristics. It increases the total number of embryos and the levels of P4 and E2 in the serum. Daidzein also ameliorates ovarian oxidative stress and inflammation through the regulation of multiple signaling pathways.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ya Du, Jiahao Liu, Shaoyuan Liu, Jiahao Hu, Siyuan Wang, Kexin Cui, Ke Yan, Xinxin Liu, Nian-Rong Wu, Xiaogan Yang, Xingwei Liang
Summary: The study demonstrated that MGE can protect aged mice from estrous cycle disorder and significantly increase their ovarian reserves. Furthermore, MGE may ameliorate age-related estrous cycle disorder and ovarian reserve decline in mice by alleviating ovarian inflammatory stress.
Article
Plant Sciences
Lin Chen, Maomao Yun, Zhenqiang Cao, Zhaojun Liang, Wenrui Liu, Min Wang, Jinqiang Yan, Songguang Yang, Xiaoming He, Biao Jiang, Qingwu Peng, Yu'e Lin
Summary: This study evaluated the changes in male flower development in cucumber under normal and heat stress conditions. It was found that heat stress led to decreased pollen fertility, abnormal tapetum and microspores, and significant changes in gene expression related to carbohydrate metabolism. Additionally, a co-expression network analysis revealed specific hub genes associated with heat stress response.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Medicine, General & Internal
O. Sena Aydos, Yunus Yukselten, Tulin Ozkan, Sinan Ozkavukcu, Meltem Tuten Erdogan, Asuman Sunguroglu, Kaan Aydos
Summary: This study found that adding FSH/testosterone to the culture medium can promote the differentiation and maturation of germ cells, and co-culturing with healthy SCs does not provide additional benefits. Additionally, the freezing-thawing process does not affect the viability and proliferation of SCs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Reut Shabtai, Yonatan B. Tzur
Summary: Testis has the highest expression levels of long intergenic non-coding RNAs (lincRNAs) in mammals, but removing highly expressed lincRNA genes does not significantly reduce male fertility. In Caenorhabditis elegans, a nematode with fewer lincRNA genes, we identified five highly expressed lincRNAs in male gonads and observed reduced male fertility when these genes were removed. The effect on fertility is likely due to early deterioration and aging of transferred sperm, rather than critical roles in meiotic processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Shuai Liu, Yongfeng Lao, Yanan Wang, Rongxin Li, Xuefeng Fang, Yunchang Wang, Xiaolong Gao, Zhilong Dong
Summary: Epigenetic alterations, especially RNA methylation, play a crucial role in various diseases, particularly in male infertility and genital system tumors. The biological effects of RNA m6A modification are dynamically regulated by methyltransferases, demethylases, and m6A binding proteins.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Konstantinos Axarlis, Maria G. Daskalaki, Sofia Michailidou, Nikolais Androulaki, Antiopi Tsoureki, Evangelia Mouchtaropoulou, Ourania Kolliniati, Ioanna Lapi, Eirini Dermitzaki, Maria Venihaki, Katerina Kousoulaki, Anagnostis Argiriou, Zouhir El Marsni, Christos Tsatsanis
Summary: Fish-derived supplements showed improvements in glucose intolerance, obesity, and type 2 diabetes, with supplements containing fish collagen having particularly beneficial properties. Additionally, collagen-containing supplements modulated the gut microbiome in high-fat induced obesity in mice.
Review
Immunology
Ourania Kolliniati, Eleftheria Ieronymaki, Eleni Vergadi, Christos Tsatsanis
Summary: Macrophages, as central mediators of innate immune responses, adapt to different environments and nutritional resources by utilizing energy at both normoxic and hypoxic conditions and modulating signaling pathways to shape different activation phenotypes. Systemic changes in diseases can also affect macrophage metabolism, resulting in altered activation phenotypes in adipose tissue or in the periphery.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Chemistry, Medicinal
Ioanna Lapi, Ourania Kolliniati, Tone Aspevik, Eleftherios E. Deiktakis, Konstantinos Axarlis, Maria G. Daskalaki, Eirini Dermitzaki, Maria Tzardi, Sotirios C. Kampranis, Zouhir El Marsni, Katerina C. Kousoulaki, Christos Tsatsanis, Maria Venihaki
Summary: Dietary supplementation with marine collagen-enriched supplements promoted tissue repair in a model of cutaneous wound healing, accelerating the healing process. The collagen-containing supplements increased the expression of chemokines for immune cell recruitment and elevated expression of the angiogenic factor VEGF-A, leading to enhanced collagen deposition in the damaged tissues.
Article
Chemistry, Medicinal
Maria G. Daskalaki, Konstantinos Axarlis, Tone Aspevik, Michail Orfanakis, Ourania Kolliniati, Ioanna Lapi, Maria Tzardi, Eirini Dermitzaki, Maria Venihaki, Katerina Kousoulaki, Christos Tsatsanis
Summary: Inflammatory bowel disease is characterized by extensive intestinal inflammation, with therapies targeting the inflammatory cascade. Nutrition plays a crucial role in the development and suppression of inflammatory bowel disease, with fish protein hydrolysates showing potential anti-inflammatory properties in a DSS-induced colitis model, providing a novel source of health-promoting dietary supplements.
Article
Immunology
Ioanna Pantazi, Ahmed A. Al-Qahtani, Fatimah S. Alhamlan, Hani Alothaid, Sabine Matou-Nasri, George Sourvinos, Eleni Vergadi, Christos Tsatsanis
Summary: The major cause of death in SARS-CoV-2 infected patients is deregulation of the innate immune system and development of cytokine storm. SARS-CoV-2 S protein can induce pro-inflammatory cytokine production in macrophages, potentially exacerbating inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
Summary: AKT-phosphorylated IWS1 promotes the alternative splicing of U2AF2, leading to regulation of mRNA nuclear export, including those encoding Type I interferons. This pathway affects sensitivity to multiple cytolytic virus infections, and may serve as a potential therapeutic target in cancer treatment.
COMMUNICATIONS BIOLOGY
(2021)
Retraction
Biology
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
COMMUNICATIONS BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Eleftherios E. Deiktakis, Eleftheria Ieronymaki, Peter Zaren, Agnes Hagsund, Elin Wirestrand, Johan Malm, Christos Tsatsanis, Ilpo T. Huhtaniemi, Aleksander Giwercman, Yvonne Lundberg Giwercman
Summary: This study explores the direct effects of adding FSH on prostate size and gene expression after androgen ablation with a GnRH antagonist. The results indicate that supplementing FSH can partially restore prostate weight and increase the expression of specific genes in mice. However, in humans, FSH has no effect on PSA production.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Zacharias Christoforakis, Eirini Dermitzaki, Eleni Paflioti, Marianna Katrinaki, Michail Deiktakis, Theodoros H. Tosounidis, Konstantine Ballalis, Christos Tsatsanis, Maria Venihaki, George Kontakis
Summary: This study found that knee osteoarthritis patients with metabolic syndrome had higher concentrations of interleukin 6, and demonstrated the critical role of infrapatellar fat pad in knee joint homeostasis and progression of KOA.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)
Retraction
Multidisciplinary Sciences
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Ahmed A. Al-Qahtani, Ioanna Pantazi, Fatimah S. Alhamlan, Hani Alothaid, Sabine Matou-Nasri, George Sourvinos, Eleni Vergadi, Christos Tsatsanis
Summary: The study found that the S protein of SARS-CoV-2 suppresses inflammatory responses in alveolar epithelial type II cells at early stages of infection by activating the PI3K/AKT pathway. Additionally, when combined with TLR2 signals, the S protein enhances PAI-1 expression, potentially affecting the local coagulation cascade.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Ioanna Pantazi, Iosif Papafragkos, Ourania Kolliniati, Ioanna Lapi, Christos Tsatsanis, Eleni Vergadi
Summary: This study found that inhibition of Akt kinase can enhance the response of non-phagocytic alveolar epithelial cells against Group B Streptococcus (GBS), promoting autophagy and GBS clearance. This finding provides a promising measure to strengthen epithelial barriers and prevent GBS invasion.
Article
Chemistry, Medicinal
Mohamed A. A. Tammam, Maria G. G. Daskalaki, Nikolaos Tsoureas, Ourania Kolliniati, Aldoushy Mahdy, Sotirios C. C. Kampranis, Christos Tsatsanis, Vassilios Roussis, Efstathia Ioannou
Summary: The chemical investigation of the organic extract of the red alga Laurencia majuscula resulted in the isolation of several new natural products with significant anti-inflammatory activity. The structures and configurations of these natural products were determined through NMR, MS, and single-crystal X-ray diffraction analysis. The most prominent anti-inflammatory activity was exhibited by compounds 5 and 18.
Article
Microbiology
Elisavet Stavropoulou, Eleftheria Ieronymaki, Evangelia Dimitroulia, Theodoros C. Constantinidis, Georgia Vrioni, Christos Tsatsanis, Athanasios Tsakris
Summary: The study found that certain Greek honey samples possess anti-inflammatory and antibacterial properties, as they can suppress the production of inflammatory mediators and reduce the translocation of bacteria in tissues. These properties are comparable to or even more potent than manuka honey.
Article
Endocrinology & Metabolism
Christos Tsatsanis, Angel Elenkov, Irene Leijonhufvud, Katerina Vaporidi, Asa Tivesten, Aleksander Giwercman
Summary: Sex hormones and sex chromosomes have different impacts on cytokines involved in sex-dependent inflammatory response. The concentration of BAFF and LPS-stimulated TNF secretion depends on sex hormone levels, while basal TNF is regulated by both sex hormone-dependent and -independent factors.
ENDOCRINE CONNECTIONS
(2023)