Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody–drug conjugates

Towards antibody-drug conjugates and prodrug strategies with extracellular stimuli-responsive drug delivery in the tumor microenvironment for cancer therapy

(2017) Nicolas Joubert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates

(2016) Alain Beck et al.   Expert Review of Proteomics

In-depth structural characterization of Kadcyla® (ado-trastuzumab emtansine) and its biosimilar candidate

(2016) Liuxi Chen et al.   mAbs

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

(2015) João P. M. Nunes et al.   CHEMICAL COMMUNICATIONS

In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab–MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios

(2015) Penny Bryant et al.   MOLECULAR PHARMACEUTICS

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

(2015) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Current ADC Linker Chemistry

(2015) Nareshkumar Jain et al.   PHARMACEUTICAL RESEARCH

Bridging Disulfides for Stable and Defined Antibody Drug Conjugates

(2014) George Badescu et al.   BIOCONJUGATE CHEMISTRY

Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer

(2014) John M. Lambert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

(2014) Felix F. Schumacher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Trastuzumab emtansine (T-DM1) for HER2-positive breast cancer

(2013) Baris Boyraz et al.   CURRENT MEDICAL RESEARCH AND OPINION

Unknown

(2013) Myra Barginear et al.   MOLECULAR MEDICINE

Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

(2012) Mathew W. Jones et al.   CHEMICAL COMMUNICATIONS

Development of Novel Bisphosphonate Prodrugs of Doxorubicin for Targeting Bone Metastases That Are Cleaved pH Dependently or by Cathepsin B: Synthesis, Cleavage Properties, and Binding Properties to Hydroxyapatite As Well As Bone Matrix

(2012) Katrin Hochdörffer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates

(2011) Robert Y. Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polymeric Dibromomaleimides As Extremely Efficient Disulfide Bridging Bioconjugation and Pegylation Agents

(2011) Mathew W. Jones et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance

(2010) Y. V. Kovtun et al.   CANCER RESEARCH

Expanded Utility of the β-Glucuronide Linker: ADCs That Deliver Phenolic Cytotoxic Agents

(2010) Scott C. Jeffrey et al.   ACS Medicinal Chemistry Letters

Antibody Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN-38) for Targeted Cancer Chemotherapy

(2008) Sung-Ju Moon et al.   JOURNAL OF MEDICINAL CHEMISTRY