Article
Biochemistry & Molecular Biology
Marta Borges-Canha, Joao Sergio Neves, Maria Manuel Silva, Fernando Mendonca, Telma Moreno, Sara Ribeiro, Joao Correa, Catarina Vale, Juliana Goncalves, Helena Urbano Ferreira, Sara Gil-Santos, Vanessa Guerreiro, Ana Sande, Selma B. Souto, Jorge Pedro, Paula Freitas, Davide Carvalho
Summary: Non-alcoholic fatty liver disease is associated with other metabolic disorders and inflammation. Body fat content, especially abdominal fat, is linked to negative cardiometabolic outcomes.
Article
Endocrinology & Metabolism
Na Lu, Gang Cheng, Chun-Ming Ma, Xiao-Li Liu
Summary: This study evaluated the relationship between hypertriglyceridemic waist (HW) phenotype, hypertriglyceridemic waist-to-height ratio (HWHtR) phenotype, and abnormal glucose metabolism in adolescents. The study found that the HWHtR phenotype was closely associated with abnormal glucose metabolism in adolescents, leading to increased insulin resistance and compensatory insulin secretion.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Obstetrics & Gynecology
Mervi Jokelainen, Beata Stach-Lempinen, Kari Teramo, Arja Nenonen, Hannu Kautiainen, Miira M. Klemetti
Summary: This study examined the associations and interactions between maternal early-pregnancy waist circumference (WC), height, and pre-pregnancy body mass index (BMI) with plasma glucose concentrations. The results showed that a large waist circumference and short height are associated with higher glucose levels, and a waist-to-height ratio above 0.5 is correlated with both fasting and post-load glucose concentrations.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Nutrition & Dietetics
Shih-Yao Su, Tsung-Han Lin, Yi-Hsueh Liu, Pei-Yu Wu, Jiun-Chi Huang, Ho-Ming Su, Szu-Chia Chen
Summary: Hyperuricemia is associated with diabetes, gout, kidney, and cardiovascular diseases, but there is limited data on sex differences in this association. This study aimed to explore sex differences in the correlations between obesity indices and hyperuricemia in Taiwan. The results showed that obesity-related indices were significantly associated with hyperuricemia in both men and women, with stronger associations found in women. This large Taiwanese study provides important insights into the relationship between obesity and hyperuricemia, highlighting the need for considering sex differences in these associations.
Article
Public, Environmental & Occupational Health
Fatemeh Moosaie, Seyede Marzie Fatemi Abhari, Niloofar Deravi, Arman Karimi Behnagh, Sadaf Esteghamati, Fatemeh Dehghani Firouzabadi, Soghra Rabizadeh, Manouchehr Nakhjavani, Alireza Esteghamati
Summary: This study followed up on 1,685 normotensive patients with type 2 diabetes and found that WHtR was a more accurate tool for predicting hypertension compared to WHR and BMI in these patients.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Jun Gyo Gwon, Jimi Choi, Cheol Woong Jung, Chang Hun Lee, Se Won Oh, Sang-Kyung Jo, Won Yong Cho, Jae Berm Park, Kyu Ha Huh, Han Ro, Seungyeup Han, Jang-Hee Cho, Sik Lee, Jaeseok Yang, Myung-Gyu Kim
Summary: This study found that an increase in waist to hip ratio (WHR) among kidney transplant recipients can increase the risk of developing cardiovascular diseases, especially in older age and diabetes patients. However, baseline body mass index (BMI) did not predict the incidence of new onset CVD in these patients. Strategies to prevent metabolic burden post-transplantation may improve cardiovascular outcomes and patient survival.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Ya Mei Li, Zhi Yong Zou, Ying Hua Ma, Jia You Luo, Jin Jing, Xin Zhang, Chun Yan Luo, Hong Wang, Hai Ping Zhao, De Hong Pan, Mi Yang Luo
Summary: The study found that anthropometric indices have good predictive performance for metabolic syndrome in Chinese adolescents, but perform poorly in overweight and obese participants. Waist circumference showed relatively better performance in all subgroup analyses.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jiang-Feng Ke, Jun-Wei Wang, Jun-Xi Lu, Zhi-Hui Zhang, Yun Liu, Lian-Xi Li
Summary: Comparing the associations between four anthropometric indices and cardio-cerebrovascular events in Chinese T2DM patients, it was found that waist-to-height ratio (WHtR) had a stronger association and may be a better indicator for evaluating cardiovascular risks in this population.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Medicine, Research & Experimental
Mridusmita Saikia, Marlena M. Holter, Leanne R. Donahue, Isaac S. Lee, Qiaonan C. Zheng, Journey L. Wise, Jenna E. Todero, Daryl J. Phuong, Darline Garibay, Reilly Coch, Kyle W. Sloop, Adolfo Garcia-Ocana, Charles G. Danko, Bethany P. Cummings
Summary: Studies have shown that liraglutide, a GLP-1 receptor agonist, can increase alpha cell GLP-1 expression in a beta cell GLP-1R-dependent manner, providing potential new targets for diabetes treatment.
Article
Nutrition & Dietetics
Nawoda Hewage, Udaya Wijesekara, Rasika Perera
Summary: The study evaluates the accuracy of anthropometric indices in identifying obesity and risk factors for non-communicable diseases (NCDs), as well as investigating the emergence of obesity-related NCDs in young women in Sri Lanka. Measurements of height, weight, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and other indicators were taken. The results show that BMI, WC, WHtR, and hip circumference (HC) are intercorrelated measurements that can be used alone or in combination to define obesity and detect NCD risk. Additionally, BMI, A Body Shape Index (ABSI), and hip index (HI) combine separate risks to generate an overall anthropometric risk index (ARI), which appears to be a highly effective predictor of cardiovascular disease.
Article
Endocrinology & Metabolism
Xue Bao, Biao Xu, Songjiang Yin, Jingxue Pan, Peter M. Nilsson, Jan Nilsson, Olle Melander, Marju Orho-Melander, Gunnar Engstrom
Summary: This study examines the differences in plasma proteomic profiles between body mass index (BMI) and waist-to-hip ratio (WHR), and their associations with the incidence of diabetes. It is found that WHR-specific proteins are associated with diabetes risk, while BMI-specific proteins are not.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Psychology, Developmental
Asima Karim, Rizwan Qaisar, M. Azhar Hussain
Summary: The study found that the mean age at menarche in the surveyed girls was 12.4 years, and there was a normal distribution of age at menarche. Girls who reached menarche were taller, heavier, and had higher BMIs, as well as larger waist and hip circumferences compared to pre-menarcheal girls. Additionally, girls from low socioeconomic status backgrounds experienced a delayed onset of menarche compared to those from middle/high SES backgrounds.
JOURNAL OF ADOLESCENCE
(2021)
Article
Gastroenterology & Hepatology
Oscar Danielsson, Markku J. Nissinen, Antti Jula, Veikko Salomaa, Satu Mannisto, Annamari Lundqvist, Markus Perola, Fredrik Aberg
Summary: The waist circumference (WC) and hip circumference (HC) show independent and opposite associations with liver disease and liver enzymes, particularly among men. HC can modify the associations between WC and liver enzymes and liver disease. WC and HC jointly reflect body fat distribution and muscle mass, which are important factors contributing to overall health.
LIVER INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Gil Zandani, Sarit Anavi-Cohen, Tamar Yudelevich, Abraham Nyska, Nativ Dudai, Zecharia Madar, Jonathan Gorelick
Summary: This study found that supplementing high-fat diet with C. iphionoides can improve metabolic effects in a NAFLD model. Consumption of C. iphionoides can reduce weight gain, liver and adipose tissue weights, and improve liver function and lipid metabolism.
Article
Endocrinology & Metabolism
Kim K. B. Clemmensen, Annemarie Koster, Johannes T. H. Nielen, Pieter C. Dagnelie, Coen D. A. Stehouwer, Hans Bosma, Anke Wesselius, Kristine Faerch, Simone J. P. M. Eussen
Summary: The timing of sleep, physical activity, and dietary intake varies between weekends and weekdays, potentially leading to impaired glucose and lipid regulation on Mondays. This study found that fasting glucose, insulin, and triglyceride concentrations were slightly higher on Mondays compared to other weekdays. There was a pronounced association between Monday and insulin concentrations in men, but not in women. The associations with glucose and triglycerides were only seen in individuals with known type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Letter
Dermatology
Mattias Henning, Kristina Ibler, Isabella Loft, Poul Jennum, Maria Didriksen, Henrik Ullum, Christian Erikstrup, Kaspar Nielsen, Mie Topholm Bruun, Henrik Hjalgrim, Erik Sorensen, Khoa Dinh, Lise Wegner Thorner, Gregor B. Jemec, Ole Pedersen
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Amalia Christina Vadmand, Anne Anker Nissen, Sidsel Mathiesen, Maria Schou Ebbesen, Tina Gerbek, Martin Kaj Fridh, Kaspar Sorensen, Bolette Hartmann, Jens Juul Holst, Klaus Muller
Summary: This study demonstrates that survivors of pediatric HSCT previously treated with total body irradiation have altered production of incretin hormones, resulting in dyslipidemia and abdominal adiposity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Maria Buur Nordskov Gabe, Liv von Voss, Jenna Elizabeth Hunt, Sarina Gadgaard, Laerke Smidt Gasbjerg, Jens Juul Holst, Hannelouise Kissow, Bolette Hartmann, Mette Marie Rosenkilde
Summary: Biased GLP-2R agonists with modifications at the N-terminal have shown improved therapeutic effects on gut and bone growth. Variants like [F6A], [F6W], and [S7W] have less GLP-2R internalization and enhanced gut trophic actions, including increased small intestine weight, villus height, and crypt depth.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Amra Jujic, Christopher Godina, Mattias Belting, Olle Melander, Jens Juul Holst, Emma Ahlqvist, Maria F. Gomez, Peter M. Nilsson, Helena Jernstrom, Martin Magnusson
Summary: Concerns have been raised about the potential increased cancer risk associated with treatment using GLP-1 receptor agonists. However, this prospective study found no association between fasting and post-challenge levels of GLP-1 and GIP and the risk of incident first cancer. Instead, higher levels of fasting GLP-1 were associated with a lower risk of incident first cancer.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Miriam Hoene, Xinjie Zhao, Juergen Machann, Andreas L. L. Birkenfeld, Martin Heni, Andreas Peter, Andreas Niess, Anja Moller, Rainer Lehmann, Guowang Xu, Cora Weigert
Summary: Physical exercise is a powerful preventative measure for cardiometabolic diseases. The individual response to lifestyle interventions varies and cannot currently be predicted. Recent research has shown that Lac-Phe produced during exercise could contribute to weight loss and potentially explain differences in the effectiveness of exercise interventions in humans.
Article
Physiology
Marina. K. K. Gerstenberg, Daniel. B. B. Andersen, Lola Torz, Carlos. M. M. Castorena, Angie. L. L. Bookout, Bolette Hartmann, Jens. F. F. Rehfeld, Natalia Petersen, Jens. J. J. Holst, Rune. E. E. Kuhre
Summary: After weight loss, the secretion of appetite-inhibiting hormones such as GLP-1 and PYY is still reduced, and other appetite-inhibiting hormones are also decreased. These results suggest that the reduced secretion of gut hormones in individuals with obesity may persist after weight loss and contribute to their susceptibility to weight regain.
Article
Endocrinology & Metabolism
Mette K. Andersen, Lars Angquist, Jette Bork-Jensen, Anna E. Jonsson, Sara E. Stinson, Camilla H. Sandholt, Malte Thodberg, Laura Maarit Pikkupeura, Emily L. Ongstad, Niels Grarup, Arne Astrup, Oluf Pedersen, Kristine Williams, Romain Barres, Thorkild I. A. Sorensen, Allan Linneberg, Joseph Grimsby, Christopher J. Rhodes, Torben Hansen
Summary: The association between FTO rs9939609 and obesity is modified by physical activity and insulin sensitivity, and these modifications are independent. High physical activity and insulin sensitivity can attenuate the effect of the FTO rs9939609 A allele on BMI. Moreover, greater physical activity and insulin sensitivity may weaken the associations between the FTO rs9939609 A allele and all-cause mortality and certain cardiometabolic outcomes. The FTO rs9939609 A allele is associated with higher expression of FTO in skeletal muscle.
Article
Gastroenterology & Hepatology
Yun Huang, Sara E. Stinson, Helene Baek Juel, Morten A. V. Lund, Louise Aas Holm, Cilius E. Fonvig, Trine Nielsen, Niels Grarup, Oluf Pedersen, Michael Christiansen, Elizaveta Chabanova, Henrik S. Thomsen, Aleksander Krag, Stefan Stender, Jens-Christian Holm, Torben Hansen
Summary: This study investigated the effects of eight previously reported genome-wide significant steatogenic variants on liver and cardiometabolic traits in children and adolescents. The results showed that these variants were associated with higher liver fat and distinct patterns of plasma lipids. The genetic risk score (GRS) based on these variants was also associated with higher prevalence of hepatic steatosis and had potential clinical utility for risk stratification.
LIVER INTERNATIONAL
(2023)
Review
Endocrinology & Metabolism
J. D. Watkins, S. Carter, G. Atkinson, F. Koumanov, J. A. Betts, J. J. Holst, J. T. Gonzalez
Summary: This systematic review aims to investigate the effect of type 2 diabetes (T2D) on GLP-1 secretion and explore potential moderators. The findings show that there is minimal and inconsistent difference in GLP-1 secretion between individuals with T2D and without T2D.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Medicine, General & Internal
Marie Moller, Rikke Borg, Iain Bressendorff, Lisbeth N. Fink, Eva Gravesen, Karina Haar Jensen, Torben Hansen, Dorrit Krustrup, Frederik Persson, Peter Rossing, Frederikke E. Sembach, Anne C. B. Thuesen, Ditte Hansen
Summary: Diabetic kidney disease is a severe complication of diabetes, and a kidney biopsy is the only way to accurately diagnose it. This study aims to investigate the prevalence of diabetic kidney disease in individuals with type 2 diabetes and explore potential targets for individualized treatment through in-depth molecular analysis of kidney tissue samples.
Article
Endocrinology & Metabolism
Tummas Ternhamar, Andreas Moller, Christoffer Martinussen, Maria S. Svane, Morten Hindso, Nils B. Jorgensen, Carsten Dirksen, Jens-Erik Beck Jensen, Bolette Hartmann, Jens J. Holst, Bente Kiens, Sten Madsbad, Kirstine N. Bojsen-Moller
Summary: Moderate intensity cycling shortly after meal intake does not increase the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery. A low glycemic index meal increases nadir glucose and reduces glucose excursions compared with a high glycemic index meal. Participants who underwent Roux-en-Y gastric bypass surgery had lower postexercise glucagon responses compared with controls.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Yordi van de Vegte, Ruben P. Eppinga, M. Yldau van der Ende, Yanick Hagemeijer, Yuvaraj V. Mahendran, Elias Y. Salfati, Albert E. Smith, Vanessa Tan, Dan V. Arking, Ioanna Ntalla, Emil A. Appel, Claudia Schurmann, Jennifer Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina U. Mononen, Kirsi F. Auro, Anne Jackson, Lawrence Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Mueller-Nurasyid, Carolina E. Roselli, Weihua Zhang, Marcus J. Kleber, Xiuqing Guo, Henry E. Lin, Francesca Pavani, Tessel Galesloot, Raymond E. Noordam, Yuri Milaneschi, Katharina Schraut, Marcel den Hoed, Frauke E. Degenhardt, Stella Trompet, Marten van den Berg, Giorgio Pistis, Yih-Chung S. Tham, Stefan L. Weiss, Xueling J. Sim, Hengtong M. Li, Peter van der Most, Ilja Nolte, Leo-Pekka R. Lyytikaeinen, M. Abdullah Said, Daniel Witte, Carlos M. Iribarren, Lenore S. Launer, Susan Ring, Paul de Vries, Peter P. Sever, Allan Linneberg, Erwin M. Bottinger, Sandosh Padmanabhan, Bruce Psaty, Nona Sotoodehnia, Ivana Kolcic, Delnaz D. Roshandel, Andrew O. Paterson, David F. Arnar, Daniel Gudbjartsson, Hilma Holm, Beverley T. Balkau, Claudia H. Silva, Christopher Newton-Cheh, Kjell Nikus, Perttu L. Salo, Karen A. Mohlke, Patricia Peyser, Heribert Schunkert, Mattias Lorentzon, Jari C. Lahti, Dabeeru C. Rao, Marilyn D. Cornelis, Jessica A. Faul, Jennifer Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie F. Waldenberger, Moritz Sinner, Konstantin E. Strauch, Graciela D. Delgado, Kent Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renee de Mutsert, Eco J. C. de Geus, Asa K. Johansson, Peter K. Joshi, Lars Lind, Andre W. Franke, Peter V. Macfarlane, Kirill Tarasov, Nicholas B. Tan, Stephan Felix, E-Shyong Q. Tai, Debra Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia P. Lindgren, Andrew T. Morris, Olli Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur J. Gudnason, Nicholas C. Timpson, Alanna B. Morrison, Patricia P. Munroe, David Strachan, Niels Grarup, Ruth J. F. R. Loos, Susan Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif J. Groop, Nicholas M. Wareham, Cornelia F. van Duijn, Mary J. Feitosa, Christopher O'Donnell, Mika Kaehoenen, Markus Perola, Michael Boehnke, Sharon L. R. Kardia, Jeanette Erdmann, Colin N. A. Palmer, Claes J. Ohlsson, David G. Porteous, Johan Eriksson, Claude Bouchard, Susanne Moebus, Peter R. Kraft, David Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kaeaeb, Annette C. Peters, John S. Chambers, Jaspal Kooner, Winfried I. Maerz, Jerome A. Rotter, Andrew Hicks, J. Gustav Smith, Lambertus A. L. M. O. Kiemeney, Dennis Mook-Kanamori, Brenda W. J. H. Penninx, Ulf F. Gyllensten, James Wilson, Stephen Burgess, Johan Sundstroem, Wolfgang Lieb, J. Wouter Jukema, Mark Eijgelsheim, Edward L. M. Lakatta, Ching-Yu Cheng, Marcus Doerr, Tien-Yin Wong, Charumathi J. Sabanayagam, Albertine Oldehinkel, Harriette Riese, Terho Lehtimaeki, Niek Verweij, Pim van der Harst
Summary: This study identifies new genetic variants associated with resting heart rate (RHR) and demonstrates that higher genetically predicted RHR is associated with a decreased risk of atrial fibrillation and ischemic stroke. Genome-wide analysis reveals multiple genetic variants in cardiomyocyte-related genes and provides insights into their electrocardiogram (ECG) signature. Mendelian randomization analyses indicate that higher genetically predicted RHR increases the risk of dilated cardiomyopathy, but reduces the risk of atrial fibrillation, ischemic stroke, and cardio-embolic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Sidsel Madsen, Steffen Yde Bak, Christian Clement Yde, Henrik Max Jensen, Tine Ahrendt Knudsen, Cecilie Baech-Laursen, Jens Juul Holst, Christoffer Laustsen, Mette Skou Hedemann
Summary: This study investigated the preventive effect of rosemary extract on obesity-related conditions and found that it can alleviate the effects of a high-fat diet through increased GLP-1 secretion and changes in microbiota composition.
Article
Public, Environmental & Occupational Health
Maria Overvad, Lars Jorge Diaz, Peter Bjerregaard, Michael Lynge Pedersen, Christina Viskum Lytken Larsen, Niels Grarup, Torben Hansen, Peter Rossing, Marit Eika Jorgensen
Summary: The aim of this study was to investigate the impact of diabetes and the diabetogenic TBC1D4 variant on kidney function in a population-based setting in Greenland. Data from a health survey and TBC1D4 genotypes of 5,336 Greenlanders were analyzed to assess the odds ratios (ORs) of albuminuria and chronic kidney disease (CKD) in individuals with and without diabetes, taking into account the effect of the TBC1D4 variant. The results showed that diabetes was associated with an elevated risk of albuminuria, while the TBC1D4 variant was protective against the development of albuminuria. However, neither diabetes nor the TBC1D4 variant were significantly associated with CKD. The findings suggest a potential renoprotective effect of the TBC1D4 variant on albuminuria, warranting further investigation.
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Ninna Karsbaek Senftleber, Kristine Skott Pedersen, Cecilie Schnoor Jorgensen, Hanne Pedersen, Marie Mathilde Bjerg Christensen, Emilie Kabel Madsen, Kristine Andersen, Emil Jorsboe, Matthew Paul Gillum, Michael Bom Frost, Torben Hansen, Marit Eika Jorgensen
Summary: In Greenland, traditional marine foods are being replaced by sucrose- and starch-rich foods. A common genetic variant in the sucrase-isomaltase (SI) gene has been found in Greenlanders, which affects their ability to digest sucrose and some starch. This variant is associated with a healthier metabolic phenotype, and this study aims to investigate the metabolic and microbial differences and food preferences among individuals with different SI genotypes.
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2023)