Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments

TORC1-dependent epilepsy caused by acute biallelicTsc1deletion in adult mice

(2013) Elisabeth Abs et al.   ANNALS OF NEUROLOGY

Everolimus treatment of refractory epilepsy in tuberous sclerosis complex

(2013) Darcy A. Krueger et al.   ANNALS OF NEUROLOGY

Chronic rapamycin treatment or lack ofS6K1does not reduce ribosome activity in vivo

(2013) Michael G Garelick et al.   CELL CYCLE

Rapamycin extends murine lifespan but has limited effects on aging

(2013) Frauke Neff et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

Systemic inhibition of mTOR kinase via rapamycin disrupts consolidation and reconsolidation of auditory fear memory

(2013) Phillip E. Mac Callum et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Prenatal Rapamycin Results in Early and Late Behavioral Abnormalities in Wildtype C57Bl/6 Mice

(2012) Peter T. Tsai et al.   BEHAVIOR GENETICS

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

(2012) J. Halloran et al.   NEUROSCIENCE

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

(2011) Smita Majumder et al.   AGING CELL

Rheb1 Is Required for mTORC1 and Myelination in Postnatal Brain Development

(2011) Jia Zou et al.   DEVELOPMENTAL CELL

Everolimus: an mTOR inhibitor for the treatment of tuberous sclerosis

(2011) David Neal Franz   Expert Review of Anticancer Therapy

 CaMKII Plays a Nonenzymatic Role in Hippocampal Synaptic Plasticity and Learning by Targeting  CaMKII to Synapses

(2011) N. Z. Borgesius et al.   JOURNAL OF NEUROSCIENCE

Rheb Is Essential for Murine Development

(2011) S. M. I. Goorden et al.   MOLECULAR AND CELLULAR BIOLOGY

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differing effects of systemically administered rapamycin on consolidation and reconsolidation of context vs. cued fear memories

(2010) E. M. Glover et al.   LEARNING & MEMORY

Optimal targeting of the mTORC1 kinase in human cancer

(2009) Heidi A Lane et al.   CURRENT OPINION IN CELL BIOLOGY

Novel Translational Control in Arc-dependent Long Term Potentiation Consolidationin Vivo

(2009) Debabrata Panja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity

(2008) M. D. Antion et al.   LEARNING & MEMORY

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE

Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation

(2008) Jacqueline Blundell et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases

(2008) Lianne C. Krab et al.   TRENDS IN GENETICS