Early-onset sleep defects inDrosophilamodels of Huntington's disease reflect alterations of PKA/CREB signaling

A Genetic Screen for Sleep and Circadian Mutants Reveals Mechanisms Underlying Regulation of Sleep in Drosophila

(2017) Mark N. Wu et al.   SLEEP

Genetic Evidence for a Role for Protein Kinase A in the Maintenance of Sleep and Thalamocortical Oscillations

(2017) Kevin Hellman et al.   SLEEP

Sleep Restores Behavioral Plasticity to Drosophila Mutants

(2015) Stephane Dissel et al.   CURRENT BIOLOGY

The Impact of Sleep and Circadian Disturbance on Hormones and Metabolism

(2015) Tae Won Kim et al.   International Journal of Endocrinology

Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment

(2014) A. J. Morton et al.   HUMAN MOLECULAR GENETICS

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease

(2014) X.-H. Lu et al.   Science Translational Medicine

Progressive sleep and electroencephalogram changes in mice carrying the Huntington’s disease mutation

(2013) Sandor Kantor et al.   BRAIN

Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis

(2013) C. Y. Daniel Lee et al.   FEBS Journal

PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model

(2013) Albert Giralt et al.   HIPPOCAMPUS

dCREB2-Mediated Enhancement of Memory Formation

(2013) T. C. Tubon et al.   JOURNAL OF NEUROSCIENCE

Increases in cAMP, MAPK Activity, and CREB Phosphorylation during REM Sleep: Implications for REM Sleep and Memory Consolidation

(2013) J. Luo et al.   JOURNAL OF NEUROSCIENCE

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis

(2013) Marishka K. Brown et al.   NEUROBIOLOGY OF AGING

The Q175 Mouse Model of Huntington’s Disease Shows Gene Dosage- and Age-Related Decline in Circadian Rhythms of Activity and Sleep

(2013) Dawn H. Loh et al.   PLoS One

Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations

(2012) Wenyu Luo et al.   AGING CELL

Circadian and sleep disorder in Huntington's disease

(2012) A. Jennifer Morton   EXPERIMENTAL NEUROLOGY

Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease

(2012) Rajnish Kumar Chaturvedi et al.   HUMAN MOLECULAR GENETICS

In Vivo Circadian Oscillation of dCREB2 and NF-κB Activity in the Drosophila Nervous System

(2012) Anne K. Tanenhaus et al.   PLoS One

Genetics of Sleep and Sleep Disorders

(2011) Amita Sehgal et al.   CELL

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

(2011) Albert Giralt et al.   HUMAN MOLECULAR GENETICS

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

Synaptic plasticity in sleep: learning, homeostasis and disease

(2011) Gordon Wang et al.   TRENDS IN NEUROSCIENCES

Asymptomatic Sleep Abnormalities Are a Common Early Feature in Patients with Huntington’s Disease

(2010) Anna O. G. Goodman et al.   Current Neurology and Neuroscience Reports

Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease

(2010) Takashi Kudo et al.   EXPERIMENTAL NEUROLOGY

CREB: a multifaceted regulator of neuronal plasticity and protection

(2010) Kensuke Sakamoto et al.   JOURNAL OF NEUROCHEMISTRY

Acute Inhibition of PKA Activity at Old Ages Ameliorates Age-Related Memory Impairment in Drosophila

(2010) D. Yamazaki et al.   JOURNAL OF NEUROSCIENCE

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis

(2010) Charlotte Soneson et al.   NEUROBIOLOGY OF DISEASE

Sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington's disease

(2010) N. Ahmad Aziz et al.   PARKINSONISM & RELATED DISORDERS

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Sleep Patterns in Patients With Huntington's Disease and Their Unaffected First-Degree Relatives: A Brief Report

(2009) Miroslav Cuturic et al.   Behavioral Sleep Medicine

Detection of early behavioral markers of Huntington's disease in R6/2 mice employing an automated social home cage

(2009) Olga Rudenko et al.   BEHAVIOURAL BRAIN RESEARCH

Identifying Sleep Regulatory Genes Using a Drosophila Model of Insomnia

(2009) L. Seugnet et al.   JOURNAL OF NEUROSCIENCE

The Effects of Caffeine on Sleep in Drosophila Require PKA Activity, But Not the Adenosine Receptor

(2009) M. N. Wu et al.   JOURNAL OF NEUROSCIENCE

The genetic and molecular regulation of sleep: from fruit flies to humans

(2009) Chiara Cirelli   NATURE REVIEWS NEUROSCIENCE

Two Different Forms of Arousal in Drosophila Are Oppositely Regulated by the Dopamine D1 Receptor Ortholog DopR via Distinct Neural Circuits

(2009) Tim Lebestky et al.   NEURON

Understanding the neurogenetics of sleep: progress from Drosophila

(2009) Susan T. Harbison et al.   TRENDS IN GENETICS

Rapid Eye Movement Sleep Disturbances in Huntington Disease

(2008) Isabelle Arnulf et al.   ARCHIVES OF NEUROLOGY

Large Ventral Lateral Neurons Modulate Arousal and Sleep in Drosophila

(2008) Vasu Sheeba et al.   CURRENT BIOLOGY

Octopamine Regulates Sleep in Drosophila through Protein Kinase A-Dependent Mechanisms

(2008) A. Crocker et al.   JOURNAL OF NEUROSCIENCE

Suppression of Neurodegeneration and Increased Neurotransmission Caused by Expanded Full-Length Huntingtin Accumulating in the Cytoplasm

(2008) Eliana Romero et al.   NEURON

Daytime somnolence and nocturnal sleep disturbances in Huntington disease

(2008) Aleksandar Videnovic et al.   PARKINSONISM & RELATED DISORDERS

Regulating gene transcription in response to cyclic AMP elevation

(2007) William A. Sands et al.   CELLULAR SIGNALLING