Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease

Energy deficit in Huntington disease: why it matters

(2011) Fanny Mochel et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

SIK2 Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB

(2011) Tsutomu Sasaki et al.   NEURON

Mitochondrial Approaches for Neuroprotection

(2010) Rajnish K. Chaturvedi et al.   Annals of the New York Academy of Sciences

The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke

(2010) Lingling Liu et al.   BRAIN RESEARCH BULLETIN

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

(2010) J. Kim et al.   HUMAN MOLECULAR GENETICS

Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation

(2010) R. K. Chaturvedi et al.   HUMAN MOLECULAR GENETICS

Partial Depletion of CREB-Binding Protein Reduces Life Expectancy in a Mouse Model of Huntington Disease

(2010) Alexandra M. Klevytska et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Inhibition of the Striatal Specific Phosphodiesterase PDE10A Ameliorates Striatal and Cortical Pathology in R6/2 Mouse Model of Huntington's Disease

(2010) Carmela Giampà et al.   PLoS One

Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington’s disease

(2009) Carmela Giampà et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial DNA background modifies the bioenergetics of NARP/MILS ATP6 mutant cells

(2009) M. D'Aurelio et al.   HUMAN MOLECULAR GENETICS

Impaired PGC-1α function in muscle in Huntington's disease

(2009) Rajnish K. Chaturvedi et al.   HUMAN MOLECULAR GENETICS

TORC1 Regulates Activity-Dependent CREB-Target Gene Transcription and Dendritic Growth of Developing Cortical Neurons

(2009) S. Li et al.   JOURNAL OF NEUROSCIENCE

CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease

(2009) Yun-Sik Choi et al.   NEUROBIOLOGY OF DISEASE

The Insulin-Regulated CREB Coactivator TORC Promotes Stress Resistance in Drosophila

(2008) Biao Wang et al.   Cell Metabolism

TORCing Up Metabolic Control in the Brain

(2008) Ville Hietakangas et al.   Cell Metabolism

PPAR: a therapeutic target in Parkinsons disease

(2008) Rajnish K. Chaturvedi et al.   JOURNAL OF NEUROCHEMISTRY

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE

Activation of TORC1 Transcriptional Coactivator through MEKK1-induced Phosphorylation

(2008) Yeung-Tung Siu et al.   MOLECULAR BIOLOGY OF THE CELL

Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

(2008) Zena DeMarch et al.   NEUROBIOLOGY OF DISEASE