- Home
- Publications
- Publication Search
- Publication Details
Title
PABPN1 suppresses TDP-43 toxicity in ALS disease models
Authors
Keywords
-
Journal
HUMAN MOLECULAR GENETICS
Volume 24, Issue 18, Pages 5154-5173
Publisher
Oxford University Press (OUP)
Online
2015-07-01
DOI
10.1093/hmg/ddv238
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A fruitful endeavor: Modeling ALS in the fruit fly
- (2015) Ian Casci et al. BRAIN RESEARCH
- The role of TDP-43 in the pathogenesis of ALS and FTLD: Figure 1
- (2015) Marco Baralle et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events
- (2014) Meredith E. Jackrel et al. CELL
- Transportin-1 and Transportin-2: Protein nuclear import and beyond
- (2014) Laure Twyffels et al. FEBS LETTERS
- Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis
- (2014) K L Jackson et al. GENE THERAPY
- TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain
- (2014) Mauricio Budini et al. HUMAN MOLECULAR GENETICS
- Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species
- (2014) E. L. Scotter et al. JOURNAL OF CELL SCIENCE
- ALS-Linked Mutations Enlarge TDP-43-Enriched Neuronal RNA Granules in the Dendritic Arbor
- (2014) L. Liu-Yesucevitz et al. JOURNAL OF NEUROSCIENCE
- Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
- (2014) Sami J Barmada et al. Nature Chemical Biology
- Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis
- (2014) C. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of TDP-43 causes age-dependent progressive motor neuron degeneration
- (2013) Yohei Iguchi et al. BRAIN
- Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis
- (2013) P. S. Estes et al. Disease Models & Mechanisms
- PABPN1: molecular function and muscle disease
- (2013) Ayan Banerjee et al. FEBS Journal
- Stress granules in neurodegeneration - lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma
- (2013) Eva Bentmann et al. FEBS Journal
- Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
- (2013) Danielle C. Diaper et al. HUMAN MOLECULAR GENETICS
- RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy
- (2013) Ryoko Ihara et al. HUMAN MOLECULAR GENETICS
- TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo
- (2013) Darshana K. Choksi et al. HUMAN MOLECULAR GENETICS
- Stress granules as crucibles of ALS pathogenesis
- (2013) Yun R. Li et al. JOURNAL OF CELL BIOLOGY
- Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models
- (2013) Hyung-Jun Kim et al. NATURE GENETICS
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
- TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis?
- (2013) Lies Vanden Broeck et al. TRENDS IN MOLECULAR MEDICINE
- Control of mRNA stability contributes to low levels of nuclear poly(A) binding protein 1 (PABPN1) in skeletal muscle
- (2013) Luciano H Apponi et al. Skeletal Muscle
- Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects
- (2012) Glenda Halliday et al. ACTA NEUROPATHOLOGICA
- TDP-43 aggregation in neurodegeneration: Are stress granules the key?
- (2012) Colleen M. Dewey et al. BRAIN RESEARCH
- The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth
- (2012) Claudia Fallini et al. HUMAN MOLECULAR GENETICS
- Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)
- (2012) Eva Bentmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeted Depletion of TDP-43 Expression in the Spinal Cord Motor Neurons Leads to the Development of Amyotrophic Lateral Sclerosis-like Phenotypes in Mice
- (2012) Lien-Szu Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulated protein aggregation: stress granules and neurodegeneration
- (2012) Benjamin Wolozin Molecular Neurodegeneration
- Does a loss of TDP-43 function cause neurodegeneration?
- (2012) Zuo-Shang Xu Molecular Neurodegeneration
- Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models
- (2012) Maria Armakola et al. NATURE GENETICS
- NIH Image to ImageJ: 25 years of image analysis
- (2012) Caroline A Schneider et al. NATURE METHODS
- Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination
- (2012) Eric B. Dammer et al. PLoS One
- Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
- (2012) I.-F. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Proline-Tyrosine Nuclear Localization Signal (PY-NLS) Is Required for the Nuclear Import of Fission Yeast PAB2, but Not of Human PABPN1
- (2012) Pierre-Luc Mallet et al. TRAFFIC
- Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS
- (2011) Patricia S. Estes et al. HUMAN MOLECULAR GENETICS
- TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
- (2011) Karli K. McDonald et al. HUMAN MOLECULAR GENETICS
- Arginine Methylation of the Nuclear Poly(A) Binding Protein Weakens the Interaction with Its Nuclear Import Receptor, Transportin
- (2011) Katharina Fronz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
- (2011) Lionel M. Igaz et al. JOURNAL OF CLINICAL INVESTIGATION
- The Survival of Motor Neuron (SMN) Protein Interacts with the mRNA-Binding Protein HuD and Regulates Localization of Poly(A) mRNA in Primary Motor Neuron Axons
- (2011) C. Fallini et al. JOURNAL OF NEUROSCIENCE
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration
- (2011) Edward B. Lee et al. NATURE REVIEWS NEUROSCIENCE
- An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity
- (2011) Weirui Guo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism
- (2011) Chunxing Yang et al. PLoS One
- Hyperphosphorylation as a Defense Mechanism to Reduce TDP-43 Aggregation
- (2011) Huei-Ying Li et al. PLoS One
- A Yeast Model of FUS/TLS-Dependent Cytotoxicity
- (2011) Shulin Ju et al. PLOS BIOLOGY
- TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
- (2010) C. Lagier-Tourenne et al. HUMAN MOLECULAR GENETICS
- Ubiquilin Modifies TDP-43 Toxicity in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)
- (2010) Keith A. Hanson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prion-like disorders: blurring the divide between transmissibility and infectivity
- (2010) M. Cushman et al. JOURNAL OF CELL SCIENCE
- TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97
- (2010) G. P. Ritson et al. JOURNAL OF NEUROSCIENCE
- Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
- (2010) S. J. Barmada et al. JOURNAL OF NEUROSCIENCE
- TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
- (2010) Ian RA Mackenzie et al. LANCET NEUROLOGY
- TDP-43 toxicity in yeast
- (2010) Maria Armakola et al. METHODS
- High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function
- (2010) Claudia Fallini et al. Molecular Neurodegeneration
- Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments
- (2010) Yong-Jie Zhang et al. Molecular Neurodegeneration
- Enhancement of proteasome activity by a small-molecule inhibitor of USP14
- (2010) Byung-Hoon Lee et al. NATURE
- Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
- (2010) Andrew C. Elden et al. NATURE
- TAR DNA-binding protein 43 in neurodegenerative disease
- (2010) Alice S. Chen-Plotkin et al. Nature Reviews Neurology
- TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity
- (2010) Aaron Voigt et al. PLoS One
- Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
- (2010) Liqun Liu-Yesucevitz et al. PLoS One
- A Drosophila model for TDP-43 proteinopathy
- (2010) Y. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rethinking ALS: The FUS about TDP-43
- (2009) Clotilde Lagier-Tourenne et al. CELL
- Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
- (2009) Edor Kabashi et al. HUMAN MOLECULAR GENETICS
- Loss of nuclear poly(A)-binding protein 1 causes defects in myogenesis and mRNA biogenesis
- (2009) Luciano H. Apponi et al. HUMAN MOLECULAR GENETICS
- Expression of TDP-43 C-terminal Fragmentsin VitroRecapitulates Pathological Features of TDP-43 Proteinopathies
- (2009) Lionel M. Igaz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
- (2009) Brian S. Johnson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 is recruited to stress granules in conditions of oxidative insult
- (2009) Claudia Colombrita et al. JOURNAL OF NEUROCHEMISTRY
- Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases
- (2009) Felix Geser et al. JOURNAL OF NEUROLOGY
- Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
- (2009) Brian D. Freibaum et al. JOURNAL OF PROTEOME RESEARCH
- Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system
- (2009) Xiaoju Wang et al. NEUROSCIENCE LETTERS
- Structural insights into TDP-43 in nucleic-acid binding and domain interactions
- (2009) P.-H. Kuo et al. NUCLEIC ACIDS RESEARCH
- Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
- (2009) Y.-J. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nervous yeast: modeling neurotoxic cell death
- (2009) Ralf J. Braun et al. TRENDS IN BIOCHEMICAL SCIENCES
- TDP-43 accumulation is common in myopathies with rimmed vacuoles
- (2008) Benno Küsters et al. ACTA NEUROPATHOLOGICA
- Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
- (2008) Lionel M. Igaz et al. AMERICAN JOURNAL OF PATHOLOGY
- Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection
- (2008) Natalia B. Nedelsky et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells
- (2008) Takashi Nonaka et al. FEBS LETTERS
- Structural determinants of the cellular localization and shuttling of TDP-43
- (2008) Y. M. Ayala et al. JOURNAL OF CELL SCIENCE
- Structural basis for RNA recognition by a type II poly(A)-binding protein
- (2008) J. Song et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity
- (2008) B. S. Johnson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now