Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination

Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor

(2017) Yuning Liao et al.   Cell Death & Disease

USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites

(2016) Byung-Hoon Lee et al.   NATURE

The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin

(2015) Shu-Ting Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G

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Anacardic acid induces cell apoptosis associated with induction of ATF4-dependent endoplasmic reticulum stress

(2014) Hongbiao Huang et al.   TOXICOLOGY LETTERS

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

(2013) Z. Tian et al.   BLOOD

The E3 Ubiquitin Ligase Siah2 Contributes to Castration-Resistant Prostate Cancer by Regulation of Androgen Receptor Transcriptional Activity

(2013) Jianfei Qi et al.   CANCER CELL

Phase II Trial of Bicalutamide in Patients with Androgen Receptor-Positive, Estrogen Receptor-Negative Metastatic Breast Cancer

(2013) A. Gucalp et al.   CLINICAL CANCER RESEARCH

Gambogic Acid Induces Apoptosis in Imatinib-Resistant Chronic Myeloid Leukemia Cells via Inducing Proteasome Inhibition and Caspase-Dependent Bcr-Abl Downregulation

(2013) X. Shi et al.   CLINICAL CANCER RESEARCH

Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor

(2013) Urszula L. Burska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of USP14 Protease Reduces I-κB Protein Levels and Increases Cytokine Release in Lung Epithelial Cells

(2013) Rachel K. Mialki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells

(2012) S Sarkar et al.   ONCOGENE

Correction: Berberine Reduces Fibronectin Expression by Suppressing the S1P-S1P2 Receptor Pathway in Experimental Diabetic Nephropathy Models

(2012) Kaipeng Huang et al.   PLoS One

Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer

(2011) Min Ni et al.   CANCER CELL

Gambogic acid enhances proteasome inhibitor-induced anticancer activity

(2011) Hongbiao Huang et al.   CANCER LETTERS

Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the Nurses' Health Study

(2011) Laura C Collins et al.   MODERN PATHOLOGY

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

(2011) Pádraig D'Arcy et al.   NATURE MEDICINE

USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation

(2011) Ryan Draker et al.   NUCLEIC ACIDS RESEARCH

A refined molecular taxonomy of breast cancer

(2011) M Guedj et al.   ONCOGENE

Triple-Negative Breast Cancer

(2010) Anthony D. Elias   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

Physiological levels of ATP negatively regulate proteasome function

(2010) Hongbiao Huang et al.   CELL RESEARCH

The Deubiquitinating Enzyme USP26 Is a Regulator of Androgen Receptor Signaling

(2010) A. M. G. Dirac et al.   MOLECULAR CANCER RESEARCH

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Management of breast cancer with targeted agents: importance of heterogenicity

(2010) Serena Di Cosimo et al.   Nature Reviews Clinical Oncology

Androgen Receptor Inhibits Estrogen Receptor-  Activity and Is Prognostic in Breast Cancer

(2009) A. A. Peters et al.   CANCER RESEARCH

Androgen Receptor Levels and Association with PIK3CA Mutations and Prognosis in Breast Cancer

(2009) A. M. Gonzalez-Angulo et al.   CLINICAL CANCER RESEARCH

What’s positive about ‘triple-negative’ breast cancer?

(2009) Sara A Hurvitz et al.   Future Oncology