Physical, Spatial, and Molecular Aspects of Extracellular Matrix ofIn VivoNiches and Artificial Scaffolds Relevant to Stem Cells Research

Creating stiffness gradient polyvinyl alcohol hydrogel using a simple gradual freezing–thawing method to investigate stem cell differentiation behaviors

(2015) Tae Ho Kim et al.   BIOMATERIALS

Fibrillar, Fibril-associated and Basement Membrane Collagens of the Arterial Wall: Architecture, Elasticity and Remodeling Under Stress

(2015) M.S. Osidak et al.   CURRENT PHARMACEUTICAL DESIGN

Human neural stem cell-derived cultures in three-dimensional substrates form spontaneously functional neuronal networks

(2015) Imogen Smith et al.   Journal of Tissue Engineering and Regenerative Medicine

Three-dimensional differentiation of bone marrow-derived mesenchymal stem cells into insulin-producing cells

(2015) Layasadat Khorsandi et al.   TISSUE & CELL

Matrix elasticity, replicative senescence and DNA methylation patterns of mesenchymal stem cells

(2014) Anne Schellenberg et al.   BIOMATERIALS

Differential regulation of morphology and stemness of mouse embryonic stem cells by substrate stiffness and topography

(2014) Dongyuan Lü et al.   BIOMATERIALS

Physical regulation of stem cells differentiation into teno-lineage: current strategies and future direction

(2014) Jia Lin Chen et al.   CELL AND TISSUE RESEARCH

The effect of elastic biodegradable polyurethane electrospun nanofibers on the differentiation of mesenchymal stem cells

(2014) Yi-Chia Kuo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Mechanical regulation of mesenchymal stem cell differentiation

(2014) Andrew J. Steward et al.   JOURNAL OF ANATOMY

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

(2014) Yubing Sun et al.   NATURE MATERIALS

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

(2014) Matthew J. Dalby et al.   NATURE MATERIALS

Spatial control of membrane receptor function using ligand nanocalipers

(2014) Alan Shaw et al.   NATURE METHODS

Monolayer culturing and cloning of human pluripotent stem cells on laminin-521–based matrices under xeno-free and chemically defined conditions

(2014) Sergey Rodin et al.   Nature Protocols

Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment

(2014) Sergey Rodin et al.   Nature Communications

Influence of Nanohelical Shape and Periodicity on Stem Cell Fate

(2013) Rajat K. Das et al.   ACS Nano

Human mesenchymal stem cell culture on heparin-based hydrogels and the modulation of interactions by gel elasticity and heparin amount

(2013) Mihye Kim et al.   Acta Biomaterialia

Deconstructing the Effects of Matrix Elasticity and Geometry in Mesenchymal Stem Cell Lineage Commitment

(2013) Greg M. Harris et al.   ADVANCED FUNCTIONAL MATERIALS

Mechanobiology and Developmental Control

(2013) Tadanori Mammoto et al.   Annual Review of Cell and Developmental Biology

Differential regulation of stiffness, topography, and dimension of substrates in rat mesenchymal stem cells

(2013) Zhan Li et al.   BIOMATERIALS

Directing stem cell fate on hydrogel substrates by controlling cell geometry, matrix mechanics and adhesion ligand composition

(2013) Junmin Lee et al.   BIOMATERIALS

3D matrix microenvironment for targeted differentiation of embryonic stem cells into neural and glial lineages

(2013) Chandrasekhar R. Kothapalli et al.   BIOMATERIALS

Stimulation of adipogenesis of adult adipose-derived stem cells using substrates that mimic the stiffness of adipose tissue

(2013) D. Adam Young et al.   BIOMATERIALS

The effect of time-dependent deformation of viscoelastic hydrogels on myogenic induction and Rac1 activity in mesenchymal stem cells

(2013) Andrew R. Cameron et al.   BIOMATERIALS

Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength

(2013) Ludovic G. Vincent et al.   Biotechnology Journal

Mechanobiology of bone marrow stem cells: From myosin-II forces to compliance of matrix and nucleus in cell forms and fates

(2013) Jae-Won Shin et al.   DIFFERENTIATION

Effects of stress-shielding on the dynamic viscoelasticity and ordering of the collagen fibers in rabbit Achilles tendon

(2013) Kazuya Ikoma et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Epithelial mechanobiology, skin wound healing, and the stem cell niche

(2013) Nicholas D. Evans et al.   Journal of the Mechanical Behavior of Biomedical Materials

Role of the extracellular matrix in regulating stem cell fate

(2013) Fiona M. Watt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Nanotopographical Cues Augment Mesenchymal Differentiation of Human Embryonic Stem Cells

(2013) Emmajayne Kingham et al.   Small

Alginate microcapsule as a 3D platform for the efficient differentiation of human embryonic stem cells to dopamine neurons

(2013) Jaemin Kim et al.   Stem Cell Research

Virus activated artificial ECM induces the osteoblastic differentiation of mesenchymal stem cells without osteogenic supplements

(2013) Jianglin Wang et al.   Scientific Reports

High-efficiency matrix modulus-induced cardiac differentiation of human mesenchymal stem cells inside a thermosensitive hydrogel

(2012) Zhenqing Li et al.   Acta Biomaterialia

Enzymatically cross-linked gelatin-phenol hydrogels with a broader stiffness range for osteogenic differentiation of human mesenchymal stem cells

(2012) Li-Shan Wang et al.   Acta Biomaterialia

Compressive elasticity of three-dimensional nanofiber matrix directs mesenchymal stem cell differentiation to vascular cells with endothelial or smooth muscle cell markers

(2012) K. Wingate et al.   Acta Biomaterialia

Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages

(2012) Goh Jih Her et al.   Acta Biomaterialia

Functional Diversity of Laminins

(2012) Anna Domogatskaya et al.   Annual Review of Cell and Developmental Biology

Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche

(2012) Maria Felice Brizzi et al.   CURRENT OPINION IN CELL BIOLOGY

Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells

(2012) Florian Rehfeldt et al.   Integrative Biology

Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility

(2012) C. Lee-Thedieck et al.   JOURNAL OF CELL SCIENCE

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells

(2012) Takamichi Miyazaki et al.   Nature Communications

Magnetic Resonance Elastography Methodology for the Evaluation of Tissue Engineered Construct Growth

(2012) Evan T. Curtis et al.   Jove-Journal of Visualized Experiments

Screening of rat mesenchymal stem cell behaviour on polydimethylsiloxane stiffness gradients

(2011) Peng-Yuan Wang et al.   Acta Biomaterialia

Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis

(2011) Johanna Ivaska et al.   Annual Review of Cell and Developmental Biology

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

(2011) Andrew. R. Cameron et al.   BIOMATERIALS

The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β

(2011) Jennifer S. Park et al.   BIOMATERIALS

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

(2011) Denise Stenzel et al.   EMBO REPORTS

Melanoma cells produce multiple laminin isoforms and strongly migrate on α5 laminin(s) via several integrin receptors

(2011) Yuko Oikawa et al.   EXPERIMENTAL CELL RESEARCH

Indentation measurements of the subendothelial matrix in bovine carotid arteries

(2011) John Peloquin et al.   JOURNAL OF BIOMECHANICS

Mechanical Load Induces a 100-Fold Increase in the Rate of Collagen Proteolysis by MMP-1

(2011) Arjun S. Adhikari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-matrix adhesions in 3D

(2011) Jill S. Harunaga et al.   MATRIX BIOLOGY

Experimental and computational analysis of soft tissue stiffness in forearm using a manual indentation device

(2011) Jarkko T. Iivarinen et al.   MEDICAL ENGINEERING & PHYSICS

The Matrisome:In SilicoDefinition andIn VivoCharacterization by Proteomics of Normal and Tumor Extracellular Matrices

(2011) Alexandra Naba et al.   MOLECULAR & CELLULAR PROTEOMICS

Nanolithographic Control of the Spatial Organization of Cellular Adhesion Receptors at the Single-Molecule Level

(2011) Mark Schvartzman et al.   NANO LETTERS

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

Artificial niche microarrays for probing single stem cell fate in high throughput

(2011) Samy Gobaa et al.   NATURE METHODS

Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate

(2011) Justin R. Tse et al.   PLoS One

Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity

(2011) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Indentation Versus Tensile Measurements of Young's Modulus for Soft Biological Tissues

(2011) Clayton T. McKee et al.   TISSUE ENGINEERING PART B-REVIEWS

Biomimetic three-dimensional microenvironment for controlling stem cell fate

(2011) H. Zhang et al.   Interface Focus

Modulation of embryonic mesenchymal progenitor cell differentiation via control over pure mechanical modulus in electrospun nanofibers

(2010) Jin Nam et al.   Acta Biomaterialia

The role of stiffness of gelatin–hydroxyphenylpropionic acid hydrogels formed by enzyme-mediated crosslinking on the differentiation of human mesenchymal stem cell

(2010) Li-Shan Wang et al.   BIOMATERIALS

Embryonic Stem Cells Do Not Stiffen on Rigid Substrates

(2010) Yeh-Chuin Poh et al.   BIOPHYSICAL JOURNAL

Marrow-Derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness

(2010) Shelly R. Peyton et al.   BIOTECHNOLOGY AND BIOENGINEERING

Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells

(2010) Guokai Chen et al.   Cell Stem Cell

Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells

(2010) Yu-Ru V Shih et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Micropatterning as a tool to decipher cell morphogenesis and functions

(2010) M. Thery   JOURNAL OF CELL SCIENCE

Stem cell mechanobiology

(2010) David A. Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

How deeply cells feel: methods for thin gels

(2010) Amnon Buxboim et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells

(2010) Jeff Holst et al.   NATURE BIOTECHNOLOGY

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511

(2010) Sergey Rodin et al.   NATURE BIOTECHNOLOGY

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

(2010) John T. Connelly et al.   NATURE CELL BIOLOGY

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Stem Cell Shape Regulates a Chondrogenic Versus Myogenic Fate Through Rac1 and N-Cadherin

(2010) Lin Gao et al.   STEM CELLS

Basement Membranes: Cell Scaffoldings and Signaling Platforms

(2010) P. D. Yurchenco   Cold Spring Harbor Perspectives in Biology

Artificial Stem Cell Niches

(2009) Matthias P. Lutolf et al.   ADVANCED MATERIALS

Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis

(2009) Payaningal R. Somanath et al.   ANGIOGENESIS

The effect of matrix stiffness on mesenchymal stem cell differentiation in a 3D thixotropic gel

(2009) Y. Shona Pek et al.   BIOMATERIALS

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

Cellular Receptors of Extracellular Matrix Molecules

(2009) Jyrki Heino et al.   CURRENT PHARMACEUTICAL DESIGN

Biomechanical Properties of In Vivo Human Skin From Dynamic Optical Coherence Elastography

(2009) Xing Liang et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Intrinsic extracellular matrix properties regulate stem cell differentiation

(2009) Gwendolen C. Reilly et al.   JOURNAL OF BIOMECHANICS

Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function

(2009) Ren Xu et al.   JOURNAL OF CELL BIOLOGY

Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion

(2009) Jinghuan Huang et al.   NANO LETTERS

Designing materials to direct stem-cell fate

(2009) Matthias P. Lutolf et al.   NATURE

Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy

(2009) Martin Stolz et al.   Nature Nanotechnology

Isolation and cultivation of stem cells from adult mouse testes

(2009) Kaomei Guan et al.   Nature Protocols

Vascular Extracellular Matrix and Arterial Mechanics

(2009) Jessica E. Wagenseil et al.   PHYSIOLOGICAL REVIEWS

Stem cell fate dictated solely by altered nanotube dimension

(2009) S. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Chondrogenesis of Human Bone Marrow Mesenchymal Stem Cells in Fibrin–Polyurethane Composites Is Modulated by Frequency and Amplitude of Dynamic Compression and Shear Stress

(2009) Zhen Li et al.   TISSUE ENGINEERING PART A

Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation

(2008) Andrew S. Rowlands et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Anoikis: A necessary death program for anchorage-dependent cells

(2008) Paola Chiarugi et al.   BIOCHEMICAL PHARMACOLOGY

Substrate Modulus Directs Neural Stem Cell Behavior

(2008) Krishanu Saha et al.   BIOPHYSICAL JOURNAL

Effects of Cyclic Mechanical Stretching on the mRNA Expression of Tendon/Ligament-Related and Osteoblast-Specific Genes in Human Mesenchymal Stem Cells

(2008) Yi-Jane Chen et al.   CONNECTIVE TISSUE RESEARCH

Extracellular Matrix: A Matter of Life and Death

(2008) Stefano Marastoni et al.   CONNECTIVE TISSUE RESEARCH

Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling

(2008) Allison L Zajac et al.   CURRENT OPINION IN CELL BIOLOGY

Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location

(2008) Elisabetta Ada Cavalcanti‐Adam et al.   HFSP Journal

Fibronectin-Tissue Transglutaminase Matrix Rescues RGD-impaired Cell Adhesion through Syndecan-4 and β1Integrin Co-signaling

(2008) Dilek Telci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic loading of deformable porous media can induce active solute transport

(2008) Michael B. Albro et al.   JOURNAL OF BIOMECHANICS

Viscoelastic response of human skin to low magnitude physiologically relevant shear

(2008) Brian Holt et al.   JOURNAL OF BIOMECHANICS

Substrate rigidity regulates Ca2+oscillation via RhoA pathway in stem cells

(2008) Tae-Jin Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro

(2008) Stefan Plantman et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Recombinant Vitronectin Is a Functionally Defined Substrate That Supports Human Embryonic Stem Cell Self-Renewal via αVβ5 Integrin

(2008) Stefan R. Braam et al.   STEM CELLS

Laminin-511 but Not -332, -111, or -411 Enables Mouse Embryonic Stem Cell Self-Renewal In Vitro

(2008) Anna Domogatskaya et al.   STEM CELLS

Identification of the Critical Extracellular Matrix Proteins that Promote Human Embryonic Stem Cell Assembly

(2008) Denis Evseenko et al.   STEM CELLS AND DEVELOPMENT

Bone Marrow-Derived Human Mesenchymal Stem Cells Become Quiescent on Soft Substrates but Remain Responsive to Chemical or Mechanical Stimuli

(2008) Jessamine P. Winer et al.   TISSUE ENGINEERING PART A

In vivo measurements of the elastic mechanical properties of human skin by indentation tests

(2007) C. Pailler-Mattei et al.   MEDICAL ENGINEERING & PHYSICS