FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion

IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights

(2017) Heming Li et al.   Molecular Cancer

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

(2016) Richard Marcotte et al.   CELL

The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models

(2016) Sen Zhang et al.   CLINICAL CANCER RESEARCH

p66 Shc Couples Mechanical Signals to RhoA through Focal Adhesion Kinase-Dependent Recruitment of p115-RhoGEF and GEF-H1

(2016) Ru-Feng Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin

(2016) Ciara H. O’Flanagan et al.   Oncotarget

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients

(2016) A. Marcell Szász et al.   Oncotarget

Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer

(2015) Hye-Young Min et al.   Molecular Cancer

Targeting a cell state common to triple-negative breast cancers

(2015) M. K. Muellner et al.   Molecular Systems Biology

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling

(2015) Fernando G Osorio et al.   NATURE MEDICINE

Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression

(2015) C Oneyama et al.   ONCOGENE

FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells

(2015) LaTonia Taliaferro-Smith et al.   Oncotarget

Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation

(2015) Susan M. Farabaugh et al.   Frontiers in Endocrinology

Can we unlock the potential of IGF-1R inhibition in cancer therapy?

(2014) Helen King et al.   CANCER TREATMENT REVIEWS

Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells

(2014) Ghaffar Muharram et al.   DEVELOPMENTAL CELL

Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis and delayed HER2 tumor onset in Fer-deficient model systems

(2014) W Sangrar et al.   ONCOGENE

Src Regulates Sequence-Dependent Beta-2 Adrenergic Receptor Recycling via Cortactin Phosphorylation

(2014) Rachel Vistein et al.   TRAFFIC

Essential Function for PDLIM2 in Cell Polarization in Three-Dimensional Cultures by Feedback Regulation of the β1-Integrin–RhoA Signaling Axis

(2014) Ravi Kiran Deevi et al.   NEOPLASIA

The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem Cells

(2014) Roberta Malaguarnera et al.   Frontiers in Endocrinology

The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growthin Vivo

(2013) Johan Lennartsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis

(2013) Joseph Ahn et al.   MOLECULAR CANCER RESEARCH

FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance

(2013) I A Ivanova et al.   ONCOGENE

Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines

(2013) M. Niepel et al.   Science Signaling

SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome

(2012) Bernard A Liu et al.   Cell Communication and Signaling

Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase

(2012) Sabine Hellwig et al.   CHEMISTRY & BIOLOGY

Fer kinase regulates cell migration through α-dystroglycan glycosylation

(2012) Tohru Yoneyama et al.   MOLECULAR BIOLOGY OF THE CELL

Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis

(2011) Johanna Ivaska et al.   Annual Review of Cell and Developmental Biology

FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF- B

(2011) C. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

(2009) Sandra Andersson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Tyrosine Kinase Fer Is a Downstream Target of the PLD-PA Pathway that Regulates Cell Migration

(2009) T. Itoh et al.   Science Signaling

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

(2008) J. H. Law et al.   CANCER RESEARCH

Insulin-like Growth Factor-I-Dependent Up-regulation of ZEB1 Drives Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells

(2008) T. R. Graham et al.   CANCER RESEARCH