Antagonizing CD105 enhances radiation sensitivity in prostate cancer

Androgen Suppression Combined with Elective Nodal and Dose Escalated Radiation Therapy (the ASCENDE-RT Trial): An Analysis of Survival Endpoints for a Randomized Trial Comparing a Low-Dose-Rate Brachytherapy Boost to a Dose-Escalated External Beam Boost for High- and Intermediate-risk Prostate Cancer

(2017) W. James Morris et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer

(2017) William U. Shipley et al.   NEW ENGLAND JOURNAL OF MEDICINE

What is the best way to radiate the prostate in 2016?

(2017) Dominic H. Moon et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Combining p53 stabilizers with metformin induces synergistic apoptosis through regulation of energy metabolism in castration-resistant prostate cancer

(2016) Long Chen et al.   CELL CYCLE

Endoglin overexpression mediates gastric cancer peritoneal dissemination by inducing mesothelial cell senescence

(2016) Zhi-Feng Miao et al.   HUMAN PATHOLOGY

A phase I study of TRC105 anti-endoglin (CD105) antibody in metastatic castration-resistant prostate cancer

(2015) Fatima H. Karzai et al.   BJU INTERNATIONAL

The regulation of radiosensitivity by p53 and its acetylation

(2015) Jing Zhang et al.   CANCER LETTERS

Taselisib (GDC-0032), a Potent  -Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations

(2015) Z. S. Zumsteg et al.   CLINICAL CANCER RESEARCH

Radiation Therapy Intensification for Solid Tumors: A Systematic Review of Randomized Trials

(2015) Kosj Yamoah et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Anatomical Patterns of Recurrence Following Biochemical Relapse in the Dose Escalation Era of External Beam Radiotherapy for Prostate Cancer

(2015) Zachary S. Zumsteg et al.   JOURNAL OF UROLOGY

TGF-β& BMP Receptors Endoglin and ALK1: Overview of their Functional Role and Status as Antiangiogenic Targets

(2014) Leon Jonker   MICROCIRCULATION

Inhibition of Endoglin-GIPC Interaction Inhibits Pancreatic Cancer Cell Growth

(2014) K. Pal et al.   MOLECULAR CANCER THERAPEUTICS

Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling

(2013) S Kumar et al.   ONCOGENE

Radiation induces aerobic glycolysis through reactive oxygen species

(2013) Jim Zhong et al.   RADIOTHERAPY AND ONCOLOGY

CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma

(2012) Stuart J. Smith et al.   ACTA NEUROPATHOLOGICA

Resistance of Glioblastoma-Initiating Cells to Radiation Mediated by the Tumor Microenvironment Can Be Abolished by Inhibiting Transforming Growth Factor-β

(2012) Matthew E. Hardee et al.   CANCER RESEARCH

Endoglin (CD105) Contributes to Platinum Resistance and Is A Target for Tumor-Specific Therapy in Epithelial Ovarian Cancer

(2012) A. J. Ziebarth et al.   CLINICAL CANCER RESEARCH

A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer

(2012) L. S. Rosen et al.   CLINICAL CANCER RESEARCH

Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint

(2012) Tohru Yamamori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genome-wide DNA Methylation Events in TMPRSS2–ERG Fusion-Negative Prostate Cancers Implicate an EZH2-Dependent Mechanism with miR-26a Hypermethylation

(2012) Stefan T. Börno et al.   Cancer Discovery

Mitochondrial Regulation of Cell Cycle and Proliferation

(2011) Valeria Gabriela Antico Arciuch et al.   ANTIOXIDANTS & REDOX SIGNALING

Acetylation is indispensable for p53 antiviral activity

(2011) Cesar Muñoz-Fontela et al.   CELL CYCLE

TGF 1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo

(2011) F. Bouquet et al.   CLINICAL CANCER RESEARCH

Understanding the limitations of radiation-induced cell cycle checkpoints

(2011) Dorothee Deckbar et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Overexpression of endoglin (CD105) is associated with recurrence in radically resected gastric cancer

(2010) YOSHIHISA KOYAMA et al.   Experimental and Therapeutic Medicine

Elevated plasma endoglin (CD105) predicts decreased response and survival in a metastatic breast cancer trial of hormone therapy

(2009) M. N. Vo et al.   BREAST CANCER RESEARCH AND TREATMENT

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration

(2009) Diana Romero et al.   CARCINOGENESIS

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Pancreatic Cancer

(2008) Anirban Maitra et al.   Annual Review of Pathology-Mechanisms of Disease

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Stromal Transforming Growth Factor-  Signaling Mediates Prostatic Response to Androgen Ablation by Paracrine Wnt Activity

(2008) V. R. Placencio et al.   CANCER RESEARCH

Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer

(2008) Brittney Jung-Hynes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoglin Promotes Transforming Growth Factor β-mediated Smad 1/5/8 Signaling and Inhibits Endothelial Cell Migration through Its Association with GIPC

(2008) Nam Y. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY