Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling
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Title
Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling
Authors
Keywords
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Journal
ONCOGENE
Volume 33, Issue 30, Pages 3970-3979
Publisher
Springer Nature
Online
2013-09-30
DOI
10.1038/onc.2013.386
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Note: Only part of the references are listed.- Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF- signaling pathways
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- (2013) Charlotte Anderberg et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2012) Christopher C. Pan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer
- (2012) L. S. Rosen et al. CLINICAL CANCER RESEARCH
- Clinical significance of sCD105 in angiogenesis and disease activity in multiple myeloma
- (2012) G. Tsirakis et al. European Journal of Internal Medicine
- Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis
- (2012) Nam Y. Lee et al. MOLECULAR BIOLOGY OF THE CELL
- Endoglin Requirement for BMP9 Signaling in Endothelial Cells Reveals New Mechanism of Action for Selective Anti-Endoglin Antibodies
- (2012) Olivier Nolan-Stevaux et al. PLoS One
- Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients
- (2011) Ana M Blázquez-Medela et al. BMC Medicine
- S100A7 Enhances Mammary Tumorigenesis through Upregulation of Inflammatory Pathways
- (2011) M. W. Nasser et al. CANCER RESEARCH
- Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling
- (2011) Marcelo Ehrlich et al. CELLULAR SIGNALLING
- Formation of Stable Homomeric and Transient Heteromeric Bone Morphogenetic Protein (BMP) Receptor Complexes Regulates Smad Protein Signaling
- (2011) Barak Marom et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth
- (2011) Roselyne Castonguay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion
- (2011) Mario A. Shields et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tumor angiogenesis: molecular pathways and therapeutic targets
- (2011) Sara M Weis et al. NATURE MEDICINE
- The Role of the TGF-β Coreceptor Endoglin in Cancer
- (2011) Eduardo Pérez-Gómez et al. TheScientificWorldJOURNAL
- The physiological role of endoglin in the cardiovascular system
- (2010) José M. López-Novoa et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis
- (2010) L. J. A. C. Hawinkels et al. CANCER RESEARCH
- The TGF-β co-receptor endoglin modulates the expression and transforming potential of H-Ras
- (2010) Juan F. Santibanez et al. CARCINOGENESIS
- Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours
- (2009) E. Fonsatti et al. CARDIOVASCULAR RESEARCH
- Casein kinase 2β as a novel enhancer of activin-like receptor-1 signaling
- (2009) Nam Y. Lee et al. FASEB JOURNAL
- Anti-endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature
- (2009) Shima Uneda et al. INTERNATIONAL JOURNAL OF CANCER
- Endoglin (CD105): A Marker of Tumor Vasculature and Potential Target for Therapy
- (2008) N. A. Dallas et al. CLINICAL CANCER RESEARCH
- Anti-tumor activity of an anti-endoglin monoclonal antibody is enhanced in immunocompetent mice
- (2008) Masanori Tsujie et al. INTERNATIONAL JOURNAL OF CANCER
- Endoglin Promotes Transforming Growth Factor β-mediated Smad 1/5/8 Signaling and Inhibits Endothelial Cell Migration through Its Association with GIPC
- (2008) Nam Y. Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transforming Growth Factor -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth
- (2008) A. C. Daly et al. MOLECULAR AND CELLULAR BIOLOGY
- MMP-9 protein level does not reflect overall MMP activity in the airways of patients with COPD
- (2008) Gillian E. Lowrey et al. RESPIRATORY MEDICINE
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