Article
Nutrition & Dietetics
Yu Qi Lee, Eugenie R. Lumbers, Tracy L. Schumacher, Clare E. Collins, Kym M. Rae, Kirsty G. Pringle
Summary: Suboptimal nutrition during pregnancy is recognized as a significant modifiable factor in the development of chronic diseases in offspring. The study found that dietary intake of pregnant Indigenous Australian women did not meet national guidelines and that maternal nutrition during pregnancy can impact fetal growth but not fetal kidney growth. Urgent strategies are needed to support and optimize nutrient intake in Indigenous pregnant women.
Review
Neurosciences
Sarah E. Steane, James S. M. Cuffe, Karen M. Moritz
Summary: Prenatal alcohol consumption can have a range of effects on pregnancy outcomes, including miscarriage, fetal growth restriction, and fetal alcohol spectrum disorder. One major mechanism behind these effects is altered DNA methylation and gene expression. Maternal intake of micronutrients like folate and choline can modify the effects of alcohol consumption on development, but more research is needed to fully understand their impact.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Cell Biology
Suqi Wu, Ketong Liu, Bingyan Zhou, Suwen Wu
Summary: Placenta, as a medium connecting pregnant women, environment, and fetus, plays a crucial role in regulating gene expression and maintaining cellular homeostasis through powerful and delicate epigenetic processes. N6-methyladenosine (m(6)A), the most prevalent RNA modification, shows dynamic reversibility and sensitivity to environmental stimuli, suggesting its significance in placental development and maternal-fetal crosstalk. Disturbance in proper m(6)A modifications due to environmental factors can lead to abnormal placentation, compromised function, and potential consequences of gestational diseases, fetal growth, and adult disease susceptibility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Nutrition & Dietetics
Eleonora Rubini, Katinka M. Snoek, Sam Schoenmakers, Sten P. Willemsen, Kevin D. Sinclair, Melek Rousian, Regine P. M. Steegers-Theunissen
Summary: High maternal homocysteine within the reference range is negatively associated with first trimester embryonic growth and birth weight, and the effects of homocysteine are dependent on conception mode.
Review
Biochemistry & Molecular Biology
Muhammad Anas, Wellison J. S. Diniz, Ana Clara B. Menezes, Lawrence P. Reynolds, Joel S. Caton, Carl R. Dahlen, Alison K. Ward
Summary: Maternal mineral nutrition during critical phases of fetal development can have lifelong impacts on individual productivity. Research has focused on the role of macronutrients in genome function and fetal programming, but little is known about the role of micronutrients and minerals in livestock species. This review will address the effects of maternal dietary mineral supply on fetal development in cattle and draw parallels with research in other animals and cell lines.
Article
Food Science & Technology
Xiaoli Gong, Xiaona Li, Yufeng Du, Jing Yang, Xuening Li, Jiaxin Li, Yangyu Zhao, Yuan Wei
Summary: This study investigates the associations between metabolites related to one-carbon metabolism and fetal growth in twins. The results show that maternal plasma levels of dimethylglycine are negatively correlated with birth weight and head circumference, while other metabolites show no significant associations. Additionally, maternal plasma levels of choline are negatively correlated with fetal abdominal circumference, and levels of dimethylglycine are negatively correlated with abdominal circumference, femur length, and estimated fetal weight. However, further studies with larger samples are needed.
FOOD SCIENCE & NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Fabio Coppede
Summary: One-carbon metabolism and epigenetic modifications regulate each other to maintain cellular homeostasis and gene expression levels. Impaired one-carbon metabolism and epigenetic modifications play crucial roles in neurodegenerative diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Agustin E. Morellato, Carla Umansky, Lucas B. Pontel
Summary: One-carbon metabolism is a crucial metabolic hub for providing one-carbon units for biosynthesis and epigenetic modifications. The central role in this hub is played by tetrahydrofolate (THF), which generates one-carbon THF intermediates through the folate or one-carbon cycle. THF derivatives feed one-carbon units into purine and thymidine synthesis, as well as the methionine cycle for AdoMet production.
Review
Obstetrics & Gynecology
Eleonora Rubini, Nicole Schenkelaars, Melek Rousian, Kevin D. Sinclair, Lieske Wekema, Marijke M. Faas, Regine P. M. Steegers-Theunissen, Sam Schoenmakers
Summary: A healthy diet before and during pregnancy is important for acquiring essential B vitamins and maintaining a healthy gut microbiota. Obese pregnant women often have derangements in 1-carbon metabolism and gut dysbiosis, which can lead to adverse pregnancy outcomes and impaired fetal development. Dietary and lifestyle counseling, along with monitoring B vitamin levels and gut microbiome, may be beneficial for preconceptional and pregnant obese women. Probiotic bacteria with folate biosynthetic capacity may also be used as intervention strategies.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ahlam Abuawad, Anne K. Bozack, Roheeni Saxena, Mary Gamble
Summary: The one-carbon metabolism-related micronutrients play a critical role in arsenic methylation, toxicity, and associated health outcomes. Folate has been shown to impact arsenic methylation, but the effects of other micronutrients are less studied and require further research.
Review
Biochemistry & Molecular Biology
Tomoki Sato, Paolo Sassone-Corsi
Summary: Food intake has a profound impact on systemic physiology, and there is a close link between food intake and circadian rhythms. The biological clock controls circadian rhythms through the cyclic expression of genes, and metabolic states also provide feedback to the molecular clock. Nutritional challenges can reprogram the circadian clock, and various factors are involved in the remodeling process.
Review
Biochemistry & Molecular Biology
Caitlyn E. Bowman, Zoltan Arany, Michael J. Wolfgang
Summary: Pregnancy is a nutritionally sensitive stage, and communication between mother and fetus through metabolites is crucial. Studies on humans and animals provide insights into the metabolic adaptations of the fetus, placenta, and mother during pregnancy. Understanding the dynamic nature of maternal-fetal metabolic communication may lead to the discovery of new biomarkers and therapeutic targets for metabolic disorders in pregnancy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Nutrition & Dietetics
Hui Peng, Huiting Xu, Jie Wu, Jiangyuan Li, Xian Wang, Zhimin Liu, Minjee Kim, Minsun S. Jeon, Ke K. Zhang, Linglin Xie
Summary: Recent studies have shown that prevention of obesity and non-alcoholic fatty liver disease should start with maternal dietary management. Maternal one-carbon supplement has been found to reduce the risk of offspring NAFLD by normalizing the methionine cycle.
Article
Oncology
Kristyna Kupkova, Savera J. Shetty, Rashidul Haque, William A. Petri, David T. Auble
Summary: This study explores how epigenetic changes in children's DNA can impact their growth and development, leading to stunting. Results show that children at risk of stunting exhibit elevated levels of H3K27ac, related to immune system activation, while overt stunting is associated with reduced H3K27ac levels, indicating metabolic changes and downregulation of immune pathways. The findings suggest that alterations in one-carbon metabolism may play a role in the development of stunting in children.
CLINICAL EPIGENETICS
(2021)
Article
Biochemistry & Molecular Biology
Carolyn F. McCabe, Jennifer L. LaBarre, Steven E. Domino, Marjorie C. Treadwell, Ana Baylin, Charles F. Burant, Dana C. Dolinoy, Vasantha Padmanabhan, Jaclyn M. Goodrich
Summary: Maternal prenatal status plays a crucial role in offspring health and disease, and alterations in DNA methylation may be a mechanism through which suboptimal prenatal conditions confer disease risk later in life. This study investigated the association between maternal one-carbon metabolites and DNA methylation patterns in newborns. The findings highlight the importance of maternal diet and cellular methylation potential in shaping offspring health.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Obstetrics & Gynecology
Isaac Gibbs, Katherine Leavey, Samantha J. Benton, David Grynspan, Shannon A. Bainbridge, Brian J. Cox
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Meeting Abstract
Developmental Biology
Samantha Benton, David Grynspan, Erika Mery, Laura Gaudet, Shannon Bainbridge
Meeting Abstract
Developmental Biology
Pascale Robineau-Charette, David Grynspan, Barbara C. Vanderhyden, Shannon A. Bainbridge
Article
Biology
S. Salsabili, A. Mukherjee, E. Ukwatta, A. D. C. Chan, S. Bainbridge, D. Grynspan
COMPUTERS IN BIOLOGY AND MEDICINE
(2019)
Article
Peripheral Vascular Disease
Pascale Robineau-Charette, David Grynspan, Samantha J. Benton, Jeremiah Gaudet, Brian J. Cox, Barbara C. Vanderhyden, Shannon A. Bainbridge
Article
Biochemical Research Methods
Jane Shearer, Matthias S. Klein, Hans J. Vogel, Shuhiba Mohammad, Shannon Bainbridge, Kristi B. Adamo
Summary: Pre-pregnancy obesity and excessive gestational weight gain are risk factors for future maternal and childhood obesity. Maternal obesity may affect the fetus through metabolic changes. Maternal serum metabolites show distinct profiles for different weight statuses, and certain metabolites can predict excessive gestational weight gain.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Developmental Biology
Sonia Dancey, Erika Mery, Ashley Esteves, Irina Oltean, Lamia Hayawi, Ken Tang, Shannon Bainbridge, Dina El Demellawy
Summary: A study examining placental histopathological lesions in pregnancies affected by hypertensive disorders and/or intrauterine growth restriction found no significant association between source of oocyte and main outcomes. However, oocyte donation IVF may increase the risk of inflammatory lesions and multiple gestation may be linked to reduced maternal vascular malperfusion and overall pathology.
Article
Medicine, General & Internal
Malia S. Q. Murphy, Samantha J. Benton, Brian Cox, Kara Nerenberg, Scott McComb, Lakshmi Krishnan, Risini D. Weeratna, Jean-Francois Pare, Alysha L. J. Dingwall-Harvey, Shannon A. Bainbridge, Andree Gruslin, Laura M. Gaudet
Summary: Women who develop preeclampsia are at high risk for cardiovascular disease. This study investigates the potential of cytokine and immune cell profiles in distinguishing low and high cardiovascular disease risk in the early postpartum period.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Fahmida Jahan, Goutham Vasam, Alex E. Green, Shannon A. Bainbridge, Keir J. Menzies
Summary: The placenta plays a crucial role in pregnancy, regulating various aspects such as adaptation to pregnancy, maternal-fetal exchange, and fetal development. Placental dysfunction, particularly in the case of preeclampsia, can lead to adverse pregnancy outcomes. This review examines the evidence of placental mitochondrial dysfunction in preeclampsia and discusses the potential of targeting mitochondria for therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Sonia R. Dancey, Samantha J. Benton, Anthea J. Lafreniere, Michal Leckie, Benjamin McLeod, Jordan Sim, Dina El-Demellawy, David Grynspan, Shannon A. Bainbridge
Summary: Placental pathology is important for investigating adverse pregnancy outcomes, but lack of standardization in reporting has limited its clinical utility. A novel placental pathology synoptic report was evaluated in comparison to narrative reports, showing that the synoptic report detected more lesions. Interobserver agreement varied based on experience. Further efforts to standardize placenta pathology reporting are needed.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Marina White, Eleanor Duffley, David Grynspan, Shannon Bainbridge, Felicia Molokoane, Theresa Rossouw, Ute Feucht, Kristin Connor
REPRODUCTIVE SCIENCES
(2020)
Meeting Abstract
Obstetrics & Gynecology
Erika Mery, Sonia Dancey, Ashley Esteves, Dina El Demellawy, Shannon Bainbridge
REPRODUCTIVE SCIENCES
(2020)
Meeting Abstract
Obstetrics & Gynecology
Anika Mukherjee, Sina Salsabili, Adrian D. C. Chan, Michal Leckie, David Grynspan, Shannon Bainbridge
REPRODUCTIVE SCIENCES
(2020)
Meeting Abstract
Obstetrics & Gynecology
Eleanor Duffl, Marina White, David Grynspan, Shannon Bainbridge, Kristin Connor
REPRODUCTIVE SCIENCES
(2020)
Meeting Abstract
Obstetrics & Gynecology
Samantha J. Benton, Erika Mery, David Grynspan, Laura Gaudet, Raywat Deonandan, Graeme Smith, Shannon A. Bainbridge
REPRODUCTIVE SCIENCES
(2020)
