Article
Biochemistry & Molecular Biology
Jin Dai, Nansi S. Boghossian, Mark A. Sarzynski, Feng Luo, Xiaoqian Sun, Jian Li, Oliver Fiehn, Jihong Liu, Liwei Chen
Summary: In this metabolome-wide association study, metabolomic markers associated with excessive gestational weight gain (GWG) were identified. Novel metabolites in the first and third trimesters were found to be associated with GWG, shedding light on the pathophysiology of GWG.
Article
Medicine, General & Internal
Ksawery Golawski, Wojciech Giermaziak, Michal Ciebiera, Cezary Wojtyla
Summary: Adequate weight gain during pregnancy is important for a healthy pregnancy, but excessive weight gain is associated with adverse pregnancy outcomes. Based on a Polish national survey of 10,319 women and 6930 children, excessive gestational weight gain is associated with higher birthweight, increased risk of birthweight over 4500 g, cesarean section/assisted delivery, pregnancy induced hypertension, hospitalization during pregnancy, and lower Apgar score in the first minute of neonate's life. However, there was no significant difference in premature rupture of membranes and labor inductions. Our study highlights the increased risk of adverse pregnancy outcomes with excessive gestational weight gain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jing-Xian Xie, Qiu-Fang Chen, Yan-Feng Fan, Yao Qin, Xue-Qin Zhang, Hong-Xiu Zhong
Summary: This study aimed to investigate the physiological variations induced by chronic hypoxia during pregnancy using a rat model. Plasma and urine metabolite profiles were analyzed at different stages of pregnancy, and multiple metabolites were found to be affected by hypoxia, including acetic acid, acetone, choline, and citric acid. The most significant changes were observed on the 11th day of gestation.
Article
Endocrinology & Metabolism
Jemina Kivela, Heidi Sormunen-Harju, Polina Girchenko, Emilia Huvinen, Beata Stach-Lempinen, Eero Kajantie, Pia M. Villa, Rebecca M. Reynolds, Esa K. Hamalainen, Marius Lahti-Pulkkinen, Katja K. Murtoniemi, Hannele Laivuori, Johan G. Eriksson, Katri Raikkonen, Saila B. Koivusalo
Summary: The study reveals that pregnant women with obesity and pregnancy disorders have similar metabolic impacts, indicating a shared metabolic origin. Furthermore, women with obesity show smaller metabolic changes during pregnancy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Otilia Perichart-Perera, Jennifer Mier-Cabrera, Claudia Montserrat Flores-Robles, Nayeli Martinez-Cruz, Lidia Arce-Sanchez, Itzel Nallely Alvarado-Maldonado, Araceli Montoya-Estrada, Jose Romo-Yanez, Ameyalli Mariana Rodriguez-Cano, Guadalupe Estrada-Gutierrez, Salvador Sosa, Mario Guzman-Huerta, Rodrigo Ayala-Yanez, Enrique Reyes-Munoz
Summary: The addition of metformin to intensive medical nutrition therapy does not provide any benefit in preventing gestational diabetes mellitus among high-risk Mexican women.
Article
Nutrition & Dietetics
Carla Patricia Novaes dos Santos Fechine, Mussara Gomes Cavalcanti Alves Monteiro, Josean Fechine Tavares, Augusto Lopes Souto, Rafaella Cristhine Pordeus Luna, Cassia Surama Oliveira da Silva, Jairo Alves da Silva, Socrates Golzio dos Santos, Maria Jose de Carvalho Costa, Darlene Camati Persuhn
Summary: Metabolomics was used to evaluate metabolic changes in overweight and obese hypertensive women before and after intervention with dietary fiber. After fiber supplementation, there was an increase in metabolites such as HDL-C, choline, and hydroxybutyrate, along with a decrease in blood pressure. Metabolomic analysis identified metabolites associated with hypertension, excess weight, and fiber intake, contributing to an increase in HDL-C and reduced blood pressure.
Article
Environmental Sciences
Andrea L. Deierlein, Haotian Wu, Allan C. Just, Allison J. Kupsco, Joseph M. Braun, Emily Oken, Diana C. Soria-Contreras, Alejandra Cantoral, Ma Luisa Pizano, Nia McRae, Martha M. Tellez-Rojo, Robert O. Wright, Andrea A. Baccarelli
Summary: The study found that prenatal exposure to phthalates was negatively associated with gestational weight gain and positively associated with long-term changes in maternal weight. Further investigation is needed to understand how phthalates influence body composition and whether they contribute to the development of obesity and other cardiometabolic diseases in women.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Karen L. Lindsay, Lauren E. Gyllenhammer, Sonja Entringer, Pathik D. Wadhwa
Summary: Objective: The study aimed to determine the association between rate of gestational weight gain (rGWG) and glucose-insulin metabolism in Hispanic pregnant women with overweight and obesity. The findings revealed that rGWG was inversely associated with beta-cell function in a high-risk population of Hispanic pregnant women with overweight and obesity, potentially contributing to the development of type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Surgery
Christos Iacovou, Tanya Maric, Miriam Bourke, Deesha Patel, Makrina Savvidou
Summary: This study compared the gestational weight gain (GWG) between women with previous bariatric surgery and those without, and investigated the correlation between GWG and birthweight (BW) or delivery of small-for-gestational-age (SGA) neonates. The results showed that post-bariatric women had similar GWG but delivered smaller babies compared to women without surgery. Additionally, GWG was not a significant predictor of BW or delivery of SGA neonates in women with previous bariatric surgery.
Article
Obstetrics & Gynecology
Xiao-guang Yin, Peng Wang, Mei-ting Zhou, De-qin Li, Rui-xue Tao, Fang-biao Tao, Yang Wang, Peng Zhu
Summary: The timing of gestational diabetes mellitus (GDM) diagnosis and gestational weight gains (GWG) during pregnancy are associated with the growth trajectory of children from perinatal to early childhood. GDM diagnosed before 26 weeks increases the risk of fetal overgrowth and higher birth weight, as well as higher BMI peak within 48 months. Maternal early GDM diagnosis and excessive gestational weight gains have additive impacts on offspring overgrowth, with higher levels of hsCRP observed in the early EGWG group.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Nutrition & Dietetics
Nicola Heslehurst, Angela C. Flynn, Lem Ngongalah, Catherine McParlin, Kathryn V. Dalrymple, Kate E. Best, Judith Rankin, Elaine McColl
Summary: This study found that pregnant women living with obesity in high deprivation areas had suboptimal dietary intake and predominantly light intensity physical activity. Most women gained weight outside of guideline recommendations, with those in class 3 obesity most likely to have inadequate weight gain. Support is needed for this population to achieve guideline recommendations.
Article
Nutrition & Dietetics
Zainab Akhter, Nicola Heslehurst, Dries Ceulemans, Judith Rankin, Roger Ackroyd, Roland Devlieger
Summary: Prior bariatric surgery is a significant risk factor for delivering small for gestational age (SGA) babies, with factors such as gestational weight gain, receiving nutritional advice, and weight management playing significant roles in influencing the risk of SGA babies.
Article
Medicine, General & Internal
Aiqi Yin, Fuying Tian, Xiaoxia Wu, Yixuan Chen, Kan Liu, Jianing Tong, Xiaonian Guan, Huafan Zhang, Linlin Wu, Jianmin Niu
Summary: This study evaluated the effect of weight gain in different trimesters on the risk of gestational diabetes mellitus (GDM). The results showed that insufficient weight gain in early pregnancy and excessive weight gain in middle pregnancy were associated with an increased risk of GDM. Strict control of weight gain in early pregnancy and sufficient nutrition in middle pregnancy are necessary.
CHINESE MEDICAL JOURNAL
(2022)
Article
Obstetrics & Gynecology
Insaf Kouba, Jaclyn Del Pozzo, Martin L. L. Lesser, Disha Shahani, Moti Gulersen, Luis A. A. Bracero, Matthew J. J. Blitz
Summary: The purpose of this study was to identify the socioeconomic and clinical factors associated with Excessive Gestational Weight Gain (EGWG). The results showed that EGWG was associated with being of Black race, being an English speaker, being overweight or obese before pregnancy, and having a mood disorder diagnosis. On the other hand, patients who were underweight, multiparous, and those with gestational diabetes were less likely to have EGWG.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Caro Minschart, Astrid Lammertyn, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: The level of gestational weight gain (GWG) during pregnancy is associated with adverse pregnancy outcomes in women with gestational diabetes (GDM) compared to women with normal glucose tolerance (NGT). Low GWG below recommended levels frequently occurs in GDM women without increased risk for adverse outcomes. Excessive GWG is associated with increased risk for neonatal hypoglycemia and worse metabolic profile postpartum in GDM women, and with higher rates of instrumental delivery and larger infants in NGT women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Sport Sciences
Catherine Everest, Taniya S. Nagpal, Sara C. S. Souza, Danilo F. Da Silva, Laura Gaudet, Shuhiba Mohammad, Jayonta Bhattacharjee, Kristi B. Adamo
Summary: Adherence to physical activity and gestational weight gain recommendations during pregnancy has been shown to improve maternal and fetal health outcomes, but does not compromise placental efficiency. Further research is needed to evaluate the potential mechanistic benefits of meeting PA and GWG guidelines on the placenta.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Developmental Biology
Kayla L. Dobson, Danilo F. da Silva, Sheila Dervis, Shuhiba Mohammad, Taniya S. Nagpal, Kristi B. Adamo
Summary: The study found that physiological/perceptual responses were higher in late-pregnancy compared to earlier time points and were associated with physical activity levels, gestational weight gain, prepregnancy body mass index, and age. These findings can be utilized to modify exercise prescriptions for future physical activity interventions in pregnant women.
BIRTH DEFECTS RESEARCH
(2021)
Review
Developmental Biology
Taniya S. Nagpal, Jayonta Bhattacharjee, Danilo F. da Silva, Sara C. S. Souza, Shuhiba Mohammad, Jessica L. Puranda, Anas Abu-Dieh, Jocelynn Cook, Kristi B. Adamo
Summary: This scoping review summarized the literature on the relationship between prenatal exercise and substance use disorders. Studies suggest that pregnant women with substance use disorders are interested in physical activity interventions during pregnancy, but may experience impaired acute metabolic and physiological responses to exercise. Animal models show preliminary evidence for improved mental health outcomes following prenatal exercise for substance use disorders.
BIRTH DEFECTS RESEARCH
(2021)
Article
Clinical Neurology
Zhiguang Zhang, Kristi B. Adamo, Nancy Ogden, Gary S. Goldfield, Anthony D. Okely, Nicholas Kuzik, Mitchell Crozier, Stephen Hunter, Madison Predy, Valerie Carson
Summary: This study longitudinally examined the relationships between sleep duration in young children and demographic factors and screen time using data from the HATCH study. The results revealed that non-Caucasian children, those from lower income families, with less-educated parents, or those who had more screen time tended to have shorter sleep duration. Targeting these groups and reducing screen time may be important for promoting adequate sleep duration in early childhood.
Article
Cell Biology
Joji Kusuyama, Ana Barbara Alves-Wagner, Royce H. Conlin, Nathan S. Makarewicz, Brent G. Albertson, Noah B. Prince, Shio Kobayashi, Chisayo Kozuka, Magnus Moller, Mette Bjerre, Jens Fuglsang, Emily Miele, Roeland J. W. Middelbeek, Yang Xiudong, Yang Xia, Lea Garneau, Jayonta Bhattacharjee, Celine Aguer, Mary Elizabeth Patti, Michael F. Hirshman, Niels Jessen, Toshihisa Hatta, Per Glud Ovesen, Kristi B. Adamo, Eva Nozik-Grayck, Laurie J. Goodyear
Summary: Poor maternal diet increases the risk of obesity and type 2 diabetes in offspring, while maternal exercise improves their metabolic health. The increase in placenta-derived SOD3 through maternal exercise activates an AMPK/TET signaling axis in the fetal offspring liver, resulting in improved glucose tolerance and liver function. This cross talk between SOD3 and offspring liver provides a central mechanism for enhancing offspring metabolic health.
Article
Anatomy & Morphology
Jayonta Bhattacharjee, Shuhiba Mohammad, Kristi B. Adamo
Summary: Exercise during pregnancy has been shown to have positive effects on the health outcomes of both mother and fetus. While the placenta plays a crucial role in pregnancy, the impact of exercise on placental biology and function is not well understood. Further research is needed to explore the potential benefits of prenatal exercise on placental growth and development.
Article
Anatomy & Morphology
S. Mohammad, J. Bhattacharjee, T. Vasanthan, C. S. Harris, S. A. Bainbridge, K. B. Adamo
Summary: Metabolomics, the application of analytical chemistry methodologies to survey the chemical composition of a biological system, is valuable for studying the maternal-fetal interface and has shown moderate usefulness in pregnancy complications. However, the placental metabolome in a healthy pregnancy remains poorly characterized and understood, with potentials for future opportunities in this emerging field.
Article
Medicine, General & Internal
Malia S. Q. Murphy, Samantha J. Benton, Brian Cox, Kara Nerenberg, Scott McComb, Lakshmi Krishnan, Risini D. Weeratna, Jean-Francois Pare, Alysha L. J. Dingwall-Harvey, Shannon A. Bainbridge, Andree Gruslin, Laura M. Gaudet
Summary: Women who develop preeclampsia are at high risk for cardiovascular disease. This study investigates the potential of cytokine and immune cell profiles in distinguishing low and high cardiovascular disease risk in the early postpartum period.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Akram Abolbaghaei, Shuhiba Mohammad, Danilo Fernandes da Silva, Kelly Ann Hutchinson, Robert L. Myette, Kristi B. Adamo, Dylan Burger
Summary: Exercise has different effects on circulating EV levels in pregnant and non-pregnant women, with a significant decrease in circulating endothelial EVs observed in the non-pregnant group. Fitness level is positively associated with baseline levels of platelet and total EVs in non-pregnant individuals, but not in pregnant individuals.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Fahmida Jahan, Goutham Vasam, Alex E. Green, Shannon A. Bainbridge, Keir J. Menzies
Summary: The placenta plays a crucial role in pregnancy, regulating various aspects such as adaptation to pregnancy, maternal-fetal exchange, and fetal development. Placental dysfunction, particularly in the case of preeclampsia, can lead to adverse pregnancy outcomes. This review examines the evidence of placental mitochondrial dysfunction in preeclampsia and discusses the potential of targeting mitochondria for therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Sonia R. Dancey, Samantha J. Benton, Anthea J. Lafreniere, Michal Leckie, Benjamin McLeod, Jordan Sim, Dina El-Demellawy, David Grynspan, Shannon A. Bainbridge
Summary: Placental pathology is important for investigating adverse pregnancy outcomes, but lack of standardization in reporting has limited its clinical utility. A novel placental pathology synoptic report was evaluated in comparison to narrative reports, showing that the synoptic report detected more lesions. Interobserver agreement varied based on experience. Further efforts to standardize placenta pathology reporting are needed.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Bethany N. Radford, Xiang Zhao, Tali Glazer, Malcolm Eaton, Danielle Blackwell, Shuhiba Mohammad, Lucas Daniel Lo Vercio, Jay Devine, Tali Shalom-Barak, Benedikt Hallgrimsson, James C. Cross, Henry M. Sucov, Yaacov Barak, Wendy Dean, Myriam Hemberger
Summary: This study demonstrates that the placenta might be a significant cause of congenital heart defects, using mouse genetic tools.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Shuhiba Mohammad, Jayonta Bhattacharjee, Velislava Tzaneva, Kelly Ann Hutchinson, Madeeha Shaikh, Danilo Fernandes da Silva, Dylan Burger, Kristi. B. B. Adamo
Summary: Exercise induces the release of small extracellular vesicles (sEVs) that may play a role in tissue cross-talk during exercise. In this study, sEVs released after exercise in pregnant and non-pregnant individuals were evaluated for their impact on trophoblasts in vitro. The results showed that exercise-associated sEVs localized within the cytoplasm of trophoblast cells, but did not significantly affect cell proliferation, gene expression, or hormone release. Further investigation is needed to reveal the potential role of exercise-associated sEVs in communicating the effects of exercise to the maternal-fetal interface.
Article
Education & Educational Research
Brianne A. Bruijns, Kristi B. Adamo, Shauna M. Burke, Valerie Carson, Jennifer D. Irwin, Patti-Jean Naylor, Brian W. Timmons, Leigh M. Vanderloo, Patricia Tucker
Summary: Educators play a significant role in shaping children's behaviors, and this study explores how their perspectives on physical activity and screen-viewing influence their provision of these activities in childcare. The findings highlight the importance of PA-related training and personal PA habits in positively influencing ECE candidates' values and perceptions of their role in promoting PA in childcare. Most candidates also express an interest in further PA/SV training.
JOURNAL OF EARLY CHILDHOOD TEACHER EDUCATION
(2022)