Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity

Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes

(2014) Raymond E. Soccio et al.   Cell Metabolism

Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond

(2014) Niels Grarup et al.   DIABETOLOGIA

Studying the Elusive Environment in Large Scale

(2014) Chirag J. Patel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Toxicogenomics and Cancer Susceptibility: Advances with Next-Generation Sequencing

(2014) Baitang Ning et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

(2014) Rachel J Perry et al.   NATURE MEDICINE

Detecting epistasis in human complex traits

(2014) Wen-Hua Wei et al.   NATURE REVIEWS GENETICS

Searching for missing heritability: Designing rare variant association studies

(2014) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Next-generation sequencing in schizophrenia and other neuropsychiatric disorders

(2013) Matthew Schreiber et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Next-Generation Sequence Analysis of Genes Associated with Obesity and Nonalcoholic Fatty Liver Disease-Related Cirrhosis in Extreme Obesity

(2013) Glenn S. Gerhard et al.   HUMAN HEREDITY

Association of Peroxisome Proliferator-Activated Receptor ^|^alpha;/^|^delta;/^|^gamma; With Obesity, and Gene^|^ndash;Gene Interaction, in the Chinese Han Population

(2013) Wenshu Luo et al.   JOURNAL OF EPIDEMIOLOGY

Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases

(2013) Francisco A. Monsalve et al.   MEDIATORS OF INFLAMMATION

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

(2013) Keri L Monda et al.   NATURE GENETICS

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity

(2013) Eleanor Wheeler et al.   NATURE GENETICS

Genetic risk factors for BMI and obesity in an ethnically diverse population: Results from the population architecture using genomics and epidemiology (PAGE) study

(2013) Megan D. Fesinmeyer et al.   Obesity

Genome-wide linkage and regional association study of obesity-related phenotypes: The GenSalt study

(2013) Angela Y. Liu et al.   Obesity

FTOgenetic variants and risk of obesity and type 2 diabetes: A meta-analysis of 28,394 Indians

(2013) Senthil K. Vasan et al.   Obesity

Rare Genomic Structural Variants in Complex Disease: Lessons from the Replication of Associations with Obesity

(2013) Robin G. Walters et al.   PLoS One

Identification of Rare Recurrent Copy Number Variants in High-Risk Autism Families and Their Prevalence in a Large ASD Population

(2013) Nori Matsunami et al.   PLoS One

Obesity genomics: assessing the transferability of susceptibility loci across diverse populations

(2013) Yingchang Lu et al.   Genome Medicine

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

(2013) Ching-Ti Liu et al.   PLoS Genetics

Using Exome Sequencing to Reveal Mutations in TREM2 Presenting as a Frontotemporal Dementia–like Syndrome Without Bone Involvement

(2013) Rita João Guerreiro et al.   JAMA Neurology

Laboratory animals as surrogate models of human obesity

(2012) Cecilia Nilsson et al.   ACTA PHARMACOLOGICA SINICA

Elements of ‘missing heritability’

(2012) Ali J. Marian   CURRENT OPINION IN CARDIOLOGY

Association of copy number variation in the AHI1 gene with risk of obesity in the Chinese population

(2012) Liansha Huang et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Ethnic differentiation of copy number variation on chromosome 16p12.3 for association with obesity phenotypes in European and Chinese populations

(2012) T-L Yang et al.   INTERNATIONAL JOURNAL OF OBESITY

Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children

(2012) M Sällman Almén et al.   INTERNATIONAL JOURNAL OF OBESITY

A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population

(2012) Liming Tao et al.   MOLECULAR BIOLOGY REPORTS

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations

(2012) Yukinori Okada et al.   NATURE GENETICS

Meta-analysis identifies common variants associated with body mass index in east Asians

(2012) Wanqing Wen et al.   NATURE GENETICS

A genome-wide association meta-analysis identifies new childhood obesity loci

(2012)   NATURE GENETICS

Associations of Variants inFTOand NearMC4RWith Obesity Traits in South Asian Indians

(2012) Senthil K. Vasan et al.   Obesity

Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis

(2012) Bo Xi et al.   PLoS One

Beyond the fourth wave of genome-wide obesity association studies

(2012) C H Sandholt et al.   Nutrition & Diabetes

A novel familial 11p15.4 microduplication associated with intellectual disability, dysmorphic features, and obesity with involvement of the ZNF214 gene

(2011) Elvera Sofos et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Exome sequencing: Dual role as a discovery and diagnostic tool

(2011) Chee-Seng Ku et al.   ANNALS OF NEUROLOGY

Genome wide association study identifies KCNMA1contributing to human obesity

(2011) Hong Jiao et al.   BMC Medical Genomics

An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference

(2011) S. D. Rees et al.   DIABETIC MEDICINE

Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians

(2011) H. Li et al.   DIABETOLOGIA

Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity

(2011) R. D. Cox et al.   Disease Models & Mechanisms

Gene-environment interaction for childhood asthma and exposure to farming in Central Europe

(2011) Markus J. Ege et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARγ and histone acetylation

(2011) Su-Jin Kim et al.   JOURNAL OF LIPID RESEARCH

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Initial impact of the sequencing of the human genome

(2011) Eric S. Lander   NATURE

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

(2011) Sébastien Jacquemont et al.   NATURE

Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

(2011) Manuel A Rivas et al.   NATURE GENETICS

Genome-Wide Association of BMI in African Americans

(2011) Maggie C.Y. Ng et al.   Obesity

Common Genetic Variants and Central Adiposity Among Asian-Indians

(2011) Steven C. Moore et al.   Obesity

Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults – The GOYA Study

(2011) Lavinia Paternoster et al.   PLoS One

Genome-Wide Gene-Environment Study Identifies Glutamate Receptor Gene GRIN2A as a Parkinson's Disease Modifier Gene via Interaction with Coffee

(2011) Taye H. Hamza et al.   PLoS Genetics

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

A Genome-wide Study Reveals Copy Number Variants Exclusive to Childhood Obesity Cases

(2010) Joseph T. Glessner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FTO Polymorphisms Are Associated with Obesity But Not with Diabetes in East Asian Populations: A Meta-analysis

(2010) Bo XI et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China

(2010) Bo Xi et al.   BMC Medical Genetics

Comparative Epigenomic Analysis of Murine and Human Adipogenesis

(2010) Tarjei S. Mikkelsen et al.   CELL

Evolutionary evidence of the effect of rare variants on disease etiology

(2010) IP Gorlov et al.   CLINICAL GENETICS

Large Copy-Number Variations Are Enriched in Cases With Moderate to Extreme Obesity

(2010) K. Wang et al.   DIABETES

Combined Analyses of 20 Common Obesity Susceptibility Variants

(2010) C. H. Sandholt et al.   DIABETES

Associations of Six Single Nucleotide Polymorphisms in Obesity-Related Genes With BMI and Risk of Obesity in Chinese Children

(2010) L. Wu et al.   DIABETES

Fine mapping of the association with obesity at the FTO locus in African-derived populations

(2010) Mohamed T. Hassanein et al.   HUMAN MOLECULAR GENETICS

Genome-wide association of anthropometric traits in African- and African-derived populations

(2010) S. J. Kang et al.   HUMAN MOLECULAR GENETICS

Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis

(2010) Ivonne Jarick et al.   HUMAN MOLECULAR GENETICS

Cellular models for understanding adipogenesis, adipose dysfunction, and obesity

(2010) Andrea Armani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

(2010) R. G. Walters et al.   NATURE

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

(2010) Iris M Heid et al.   NATURE GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women

(2010) Damien C. Croteau-Chonka et al.   Obesity

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

(2010) André Scherag et al.   PLoS Genetics

Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity

(2009) Emily Sonestedt et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals

(2009) D. Meyre et al.   DIABETES

Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study

(2009) T. O. Kilpelainen et al.   HUMAN MOLECULAR GENETICS

Common body mass index-associated variants confer risk of extreme obesity

(2009) Chris Cotsapas et al.   HUMAN MOLECULAR GENETICS

Energy metabolism, fuel selection and body weight regulation

(2009) J Galgani et al.   INTERNATIONAL JOURNAL OF OBESITY

Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population

(2009) Bao-Yong Sha et al.   JOURNAL OF HUMAN GENETICS

Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha

(2009) L S Carroll et al.   MOLECULAR PSYCHIATRY

Large, rare chromosomal deletions associated with severe early-onset obesity

(2009) Elena G. Bochukova et al.   NATURE

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

(2009) Joseph T. Glessner et al.   NATURE

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

(2009) Yoon Shin Cho et al.   NATURE GENETICS

Replication of Association Between a Common Variant Near Melanocortin-4 Receptor Gene and Obesity-related Traits in Asian Sikhs

(2009) Latonya F. Been et al.   Obesity

The Medical Risks of Obesity

(2009) Xavier Pi-Sunyer   POSTGRADUATE MEDICINE

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

(2009) Cecilia M. Lindgren et al.   PLoS Genetics

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium

(2009) Nancy L. Heard-Costa et al.   PLoS Genetics

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

PPAR  and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

(2008) M. I. Lefterova et al.   GENES & DEVELOPMENT

Genome-wide association scans identified CTNNBL1 as a novel gene for obesity

(2008) Yong-Jun Liu et al.   HUMAN MOLECULAR GENETICS

Global burden of obesity in 2005 and projections to 2030

(2008) T Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY

The contribution of animal models to the study of obesity

(2008) John Speakman et al.   LABORATORY ANIMALS

Common nonsynonymous variants in PCSK1 confer risk of obesity

(2008) Michael Benzinou et al.   NATURE GENETICS

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

(2008) John C Chambers et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome

(2008) Joan C. Han et al.   NEW ENGLAND JOURNAL OF MEDICINE

McKusick's Online Mendelian Inheritance in Man (OMIM(R))

(2008) J. Amberger et al.   NUCLEIC ACIDS RESEARCH

No Association Between INSIG2 Gene rs7566605 Polymorphism and Being Overweight in Japanese Population

(2008) Yasuharu Tabara et al.   Obesity

Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP

(2008) Struan F. A. Grant et al.   PLoS One

Non-Replication of Genome-Wide Based Associations between Common Variants in INSIG2 and PFKP and Obesity in Studies of 18,014 Danes

(2008) Camilla H. Andreasen et al.   PLoS One