Dicer partner protein tunes the length of miRNAs using base-mismatch in the pre-miRNA stem

The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2

(2017) Suresh K. Kandasamy et al.   RNA

Phosphate-binding pocket in Dicer-2 PAZ domain for high-fidelity siRNA production

(2016) Suresh K. Kandasamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Drosophila Dicer-1 Partner Loquacious Enhances miRNA Processing from Hairpins with Unstable Structures at the Dicing Site

(2016) Mandy Yu Theng Lim et al.   Cell Reports

Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis

(2016) Xiaoping Lin et al.   PLoS One

Variability of miRNA expression during the differentiation of human embryonic stem cells into retinal pigment epithelial cells

(2015) Zhidong Yuan et al.   GENE

Comprehensive expression analysis of miRNA in breast cancer at the miRNA and isomiR levels

(2015) Xianjin Wu et al.   GENE

Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis

(2015) Ross C. Wilson et al.   MOLECULAR CELL

Trbp regulates heart function through microRNA-mediated Sox6 repression

(2015) Jian Ding et al.   NATURE GENETICS

piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production

(2015) B. W. Han et al.   SCIENCE

piPipes: a set of pipelines for piRNA and transposon analysis via small RNA-seq, RNA-seq, degradome- and CAGE-seq, ChIP-seq and genomic DNA sequencing

(2014) Bo W. Han et al.   BIOINFORMATICS

Systematic Study of Drosophila MicroRNA Functions Using a Collection of Targeted Knockout Mutations

(2014) Ya-Wen Chen et al.   DEVELOPMENTAL CELL

Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain

(2014) R. Fukunaga et al.   EMBO JOURNAL

Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs

(2014) Jia Sheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

5′ isomiR variation is of functional and evolutionary importance

(2014) Geok Chin Tan et al.   NUCLEIC ACIDS RESEARCH

YM500v2: a small RNA sequencing (smRNA-seq) database for human cancer miRNome research

(2014) Wei-Chung Cheng et al.   NUCLEIC ACIDS RESEARCH

A Novel miR-451a isomiR, Associated with Amelanotypic Phenotype, Acts as a Tumor Suppressor in Melanoma by Retarding Cell Migration and Invasion

(2014) Sankhiros Babapoor et al.   PLoS One

Deletion of Human tarbp2 Reveals Cellular MicroRNA Targets and Cell-Cycle Function of TRBP

(2014) Yoosik Kim et al.   Cell Reports

Highly Improved Gene Targeting by Germline-Specific Cas9 Expression in Drosophila

(2013) Shu Kondo et al.   GENETICS

Substrate-specific structural rearrangements of human Dicer

(2013) David W Taylor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA arm selection and isomiR distribution in gastric cancer

(2012) Sung-Chou Li et al.   BMC GENOMICS

Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals

(2012) Ryuya Fukunaga et al.   CELL

Functional screening identifies miRNAs inducing cardiac regeneration

(2012) Ana Eulalio et al.   NATURE

The molecular architecture of human Dicer

(2012) Pick-Wei Lau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Plant secondary siRNA production determined by microRNA-duplex structure

(2012) P. A. Manavella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRBP alters human precursor microRNA processing in vitro

(2012) H. Y. Lee et al.   RNA

Phosphate and R2D2 Restrict the Substrate Specificity of Dicer-2, an ATP-Driven Ribonuclease

(2011) Elif Sarinay Cenik et al.   MOLECULAR CELL

Unique functionality of 22-nt miRNAs in triggering RDR6-dependent siRNA biogenesis from target transcripts in Arabidopsis

(2010) Josh T Cuperus et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of microRNA length variety

(2010) Julia Starega-Roslan et al.   NUCLEIC ACIDS RESEARCH

22-nucleotide RNAs trigger secondary siRNA biogenesis in plants

(2010) H.-M. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic isomiR regulation in Drosophila development

(2010) S. L. Fernandez-Valverde et al.   RNA

Structure of Arabidopsis HYPONASTIC LEAVES1 and Its Molecular Implications for miRNA Processing

(2010) Seong Wook Yang et al.   STRUCTURE

Characterization of the TRBP domain required for Dicer interaction and function in RNA interference

(2009) Sylvanne M Daniels et al.   BMC MOLECULAR BIOLOGY

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

Structural insights into RNA processing by the human RISC-loading complex

(2009) Hong-Wei Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Human Dicer-TRBP Complex by Electron Microscopy

(2009) Pick-Wei Lau et al.   STRUCTURE

Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells

(2008) R. D. Morin et al.   GENOME RESEARCH