Article
Cell Biology
Manish Pandey, Arthur Luhur, Nicholas S. S. Sokol, Geetanjali Chawla
Summary: This study investigated the impact of position, order, stem-base, and terminal loop sequences on the differential processing of miRNAs in clustered microRNAs. The results highlighted the importance of structural attributes in regulating the expression of polycistronic miRNAs and provided specific guidelines for achieving differential expression within a cluster.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kotaro Nakanishi
Summary: The biosynthesis pathways of microRNAs have been well characterized, with small RNAs shorter than 19 nt also binding to AGO proteins and regulating mRNA expression post-transcriptionally.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Cell Biology
William H. Walker
Summary: This article discusses the impact of microRNAs on male fertility, specifically focusing on the regulation of gene expression in germ cells and Sertoli cells. The study highlights the importance of miRNA in differentiating spermatogonia, spermatocytes, spermatids, and Sertoli cells, and how they contribute to the overall process of spermatogenesis. Additionally, the role of miRNAs in signaling the initiation of puberty in a non-human primate model is also discussed.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemical Research Methods
Leandro A. Bugnon, Cristian Yones, Diego H. Milone, Georgina Stegmayer
Summary: Six recent methods for predicting miRNAs in the genome were reviewed and compared on different genome-wide datasets. It was found that all methods performed similarly for smaller genomes and imbalances, but deep learning approaches using raw sequence information achieved the best scores for larger datasets like the human genome.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Cell & Tissue Engineering
Ali Rajool Dezfuly, Azadeh Safaee, Hossein Salehi
Summary: Extracellular vesicles (EVs), including microvesicles and exosomes, carry vital information such as lipids, proteins, mRNAs, and microRNAs to target cells. Studies have shown that the therapeutic effects of stem cells are attributed to the miRNAs in their EVs, which may help in developing new therapeutic techniques for retinal degenerative diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Soudeh Ghafouri-Fard, Mohammadreza Hajiesmaeili, Hamed Shoorei, Zahra Bahroudi, Mohammad Taheri, Guive Sharifi
Summary: Stem cells and cancer stem cells possess the abilities of self-renewal and differentiation, with molecular pathways like Wnt, Notch, and Hedgehog influencing their functions. miRNAs and lncRNAs have been found to regulate the functions of CSCs, particularly in breast cancer and hepatocellular carcinoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Claire Loussouarn, Yves-Marie Pers, Claire Bony, Christian Jorgensen, Daniele Noel
Summary: MSCs stimulate tissue repair by releasing EVs, which contain various molecules including miRNAs. These EVs impact the metabolism and oxidative stress of target cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Jian Zhou, Cheng Qiu, Zhihua Fan, Tianyi Liu, Tang Liu
Summary: Circular RNAs are novel endogenous non-coding RNAs that play a critical role in stem cell differentiation by modulating miRNA expression and related gene translation. With the rapid advancement of bioinformatics analysis tools and high-throughput RNA sequencing, numerous circRNAs with important biological features have been identified, providing reference guidance for future studies on stem cell differentiation.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Chemistry, Analytical
Yukiko Kamiya, Hiroshi Kamimoto, Hongyu Zhu, Hiroyuki Asanuma
Summary: miRNAs are small non-coding RNAs that regulate gene expression through the RNAi system in cells. Different steps regulate the generation of miRNA, and using FRET-labeled pre-miRNAs can help understand the maturation process of miRNA.
Article
Biochemistry & Molecular Biology
Xiaoyan Liu, Zhenzhen Chen, Shuangyue Li, Ling Jin, Xiao Cui, Changting Cui, Yue Deng, Qiannan Gao, Luyun Fan, Yaping Niu, Wenjie Wang, Chunmei Cui, Jiuchang Zhong, Qinghua Cui, Bin Geng, Jun Cai
Summary: G protein-coupled receptors (GPCRs) are the largest family of druggable targets, and their biological functions depend on different ligands and intracellular interactomes. Some microRNAs (miRNAs) bind as ligands to specific receptors to regulate various cellular responses. In this study, it was found that miRNA hsa-let-7a-2 binds non-competitively to the intracellular loop of AGTR2, negatively regulating its activated signals.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jessica J. Abner, Jeffrey L. Franklin, Margaret A. Clement, Scott A. Hinger, Ryan M. Allen, Xiao Liu, Stefanie Kellner, Junzhou Wu, John Karijolich, Qi Liu, Kasey C. Vickers, Peter Dedon, Alissa M. Weaver, Robert J. Coffey, James G. Patton
Summary: The study shows that METTL3 modification plays a role in cellular levels of specific miRNAs and their export into extracellular vesicles (EVs), with implications for the growth and drug resistance spread of colorectal cancer cells.
Review
Biochemistry & Molecular Biology
Victoria A. Stark, Caroline O. B. Facey, Vignesh Viswanathan, Bruce M. Boman
Summary: MicroRNAs play a critical role in regulating stem cells and their aberrant expression is associated with various cancers. They can target different SC genes alone or in clusters to influence CSC phenotype, and are linked to CRC patient survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Antara Banerjee, Dikshita Deka, Makalakshmi Muralikumar, Alexander Sun-Zhang, Atil Bisgin, Cynthia Christopher, Hong Zhang, Xiao-Feng Sun, Surajit Pathak
Summary: Colon cancer remains a major cause of death, and cancer stem cells play a significant role in its progression, metastasis, and recurrence. miRNAs have become increasingly important in the context of colon cancer, and a comprehensive understanding of their regulatory roles could lead to effective treatment strategies.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Neurosciences
Emad M. Elzayat, Sherif A. Shahien, Ahmed A. El-Sherif, Mohamed Hosney
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive impairment, memory loss, and behavioral changes. The exact causes of AD are not fully understood, but amyloid-beta peptides and tau proteins are believed to play a role. Various demographic, genetic, and environmental risk factors contribute to the onset and progression of AD. MicroRNA levels show promise as a diagnostic tool for AD, and while there are currently only two FDA-approved therapeutic drugs, new approaches such as acitretin and stem cells show potential for treatment. This review highlights promising diagnostic techniques and therapeutic approaches for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Karol Talkowski, Kamil Kielbasinski, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boron, Marcin Oplawski
Summary: Salinomycin has a strong pro-apoptotic effect on endometrial cancer cells, influencing the expression of genes related to stemness and regulating miRNA expression. Treatment with salinomycin at different concentrations can result in varying levels of cell death and changes in gene expression.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryuya Fukunaga
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Li Zhu, Suresh K. Kandasamy, Susan E. Liao, Ryuya Fukunaga
NATURE COMMUNICATIONS
(2018)
Correction
Multidisciplinary Sciences
Li Zhu, Suresh K. Kandasamy, Susan E. Liao, Ryuya Fukunaga
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Susan E. Liao, Suresh K. Kandasamy, Li Zhu, Ryuya Fukunaga
Article
Multidisciplinary Sciences
Li Zhu, Susan E. Liao, Yiwei Ai, Ryuya Fukunaga
Article
Biochemistry & Molecular Biology
Li Zhu, Susan E. Liao, Ryuya Fukunaga
Article
Genetics & Heredity
Li Zhu, Ryuya Fukunaga
Summary: This study identified a novel RNA-binding protein Maca crucial for the successful expression of gigantic male fertility factor genes, spermatogenesis, and male fertility in fruit fly Drosophila. Maca protein plays a key role in promoting transcription processivity, splicing of gigantic introns, and/or protection of transcripts from premature degradation of the fertility factor genes kl-2, kl-3, and kl-5.
Article
Multidisciplinary Sciences
Susan E. Liao, Yiwei Ai, Ryuya Fukunaga
Article
Medicine, Research & Experimental
Styliani Vakrou, Ryuya Fukunaga, D. Brian Foster, Lars Sorensen, Yamin Liu, Yufan Guan, Kirubel Woldemichael, Roberto Pineda-Reyes, Ting Liu, Jill C. Tardiff, Leslie A. Leinwand, Carlo G. Tocchetti, Theodore P. Abraham, Brian O'Rourke, Miguel A. Aon, M. Roselle Abraham