Biocatalytic approaches towards the stereoselective synthesis of vicinal amino alcohols

Transaminase biocatalysis: optimization and application

(2017) Fei Guo et al.   GREEN CHEMISTRY

Hybrid Organo- and Biocatalytic Process for the Asymmetric Transformation of Alcohols into Amines in Aqueous Medium

(2017) Elisa Liardo et al.   ACS Catalysis

Synthesis of 1-(S)-phenylethanol and ethyl (R)-4-chloro-3-hydroxybutanoate using recombinant Rhodococcus erythropolis alcohol dehydrogenase produced by two yeast species

(2016) Jakub Kasprzak et al.   BIOCHEMICAL ENGINEERING JOURNAL

Easy kinetic resolution of some β-amino alcohols by Candida antarctica lipase B catalyzed hydrolysis in organic media

(2016) Affef Alalla et al.   TETRAHEDRON-ASYMMETRY

Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis

(2016) Shuke Wu et al.   Nature Communications

EngineeredL-Serine Hydroxymethyltransferase fromStreptococcus thermophilusfor the Synthesis of α,α-Dialkyl-α-Amino Acids

(2015) Karel Hernandez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanding the threonine aldolase toolbox for the asymmetric synthesis of tertiary α-amino acids

(2015) Kateryna Fesko et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Modelling and optimisation of the one-pot, multi-enzymatic synthesis of chiral amino-alcohols based on microscale kinetic parameter determination

(2015) L. Rios-Solis et al.   CHEMICAL ENGINEERING SCIENCE

Multi-step biocatalytic strategies for chiral amino alcohol synthesis

(2015) Maria F. Villegas-Torres et al.   ENZYME AND MICROBIAL TECHNOLOGY

Chemoenzymatic synthesis of ( R )- and ( S )-propranolol using an engineered epoxide hydrolase with a high turnover number

(2015) Xu-Dong Kong et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Multi-step synthesis strategies towards 1,2-amino alcohols with special emphasis on phenylpropanolamines

(2015) Torsten Sehl et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Highly selective chemoenzymatic synthesis of enantiopure orthogonally protected trans-3-amino-4-hydroxypiperidines

(2015) Ángela Villar-Barro et al.   TETRAHEDRON

Efficient 2-step biocatalytic strategies for the synthesis of all nor(pseudo)ephedrine isomers

(2014) Torsten Sehl et al.   GREEN CHEMISTRY

Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials

(2013) Torsten Sehl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent trends and novel concepts in cofactor-dependent biotransformations

(2013) Selin Kara et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Non-linear kinetic modelling of reversible bioconversions: Application to the transaminase catalyzed synthesis of chiral amino-alcohols

(2013) L. Rios-Solis et al.   BIOCHEMICAL ENGINEERING JOURNAL

Protein engineering with unnatural amino acids

(2013) William H Zhang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

One-pot combination of enzyme and Pd nanoparticle catalysis for the synthesis of enantiomerically pure 1,2-amino alcohols

(2013) Joerg H. Schrittwieser et al.   GREEN CHEMISTRY

DrugBank 4.0: shedding new light on drug metabolism

(2013) Vivian Law et al.   NUCLEIC ACIDS RESEARCH

Chemoenzymatic synthesis of orthogonally protected (3R,4R)- and (3S,4S)-trans-3-amino-4-hydroxypyrrolidines

(2013) Jesús A. Rodríguez-Rodríguez et al.   TETRAHEDRON

Biocatalytic Approaches to the Henry (Nitroaldol) Reaction

(2012) Sinéad E. Milner et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diastereoselective synthesis of vicinal amino alcohols

(2012) Oskari K. Karjalainen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cyclic trans-β-amino alcohols: preparation and enzymatic kinetic resolution

(2012) Abdul Rouf et al.   TETRAHEDRON-ASYMMETRY

An Efficient Dynamic Kinetic Resolution of N-Heterocyclic 1,2-Amino Alcohols

(2011) Richard Lihammar et al.   ADVANCED SYNTHESIS & CATALYSIS

Selective biocatalytic aminolysis of (±)-epichlorohydrin: Synthesis and ICAM-1 inhibitory activity of (S)-(+)-3-arylamino-1-chloropropan-2-ols

(2011) Pankaj Gupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

S-Selective Mixed Carboligation by Structure-Based Design of the Pyruvate Decarboxylase from Acetobacter pasteurianus

(2011) Dörte Rother neé Gocke et al.   ChemCatChem

Enzymatic synthesis of optical pure β-nitroalcohols by combining d-aminoacylase-catalyzed nitroaldol reaction and immobilized lipase PS-catalyzed kinetic resolution

(2011) Fan Xu et al.   GREEN CHEMISTRY

Synthesis of (R)-β-nitro alcohols catalyzed by R-selective hydroxynitrile lyase from Arabidopsis thaliana in the aqueous–organic biphasic system

(2011) Ken-ichi Fuhshuku et al.   JOURNAL OF BIOTECHNOLOGY

Hydroxynitrile Lyases: Insights into Biochemistry, Discovery, and Engineering

(2011) Mohammad Dadashipour et al.   ACS Catalysis

Threonine aldolases—screening, properties and applications in the synthesis of non-proteinogenic β-hydroxy-α-amino acids

(2010) Nina Dückers et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Kinetic studies of the asymmetric Henry reaction catalyzed by hydroxynitrile lyase fromHevea brasiliensis

(2010) Ruslan Yuryev et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo

(2010) Caroline D. Scatena et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Enzymatic Synthesis of Enantiomerically Pure β-Amino Ketones, β-Amino Esters, and β-Amino Alcohols with Baeyer-Villiger Monooxygenases

(2010) Jessica Rehdorf et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Developments in Methodology for the Direct Oxyamination of Olefins

(2010) Timothy J. Donohoe et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent progress in stereoselective synthesis with aldolases

(2010) Pere Clapés et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Directed evolution of an aminoalcohol dehydrogenase for efficient production of double chiral aminoalcohols

(2010) Nobuyuki Urano et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Enzymatic resolution of methyl (2E, 4R*,5S*)-4-(N-benzyl-N-methyl)amino-5-hydroxyhex-2-enoate

(2010) Mikio Fujii et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Resolution of 2,2-Disubstituted Epoxides via Biocatalytic Azidolysis

(2010) Carmela Molinaro et al.   ORGANIC LETTERS

Protein-Mediated Nitroaldol Addition in Aqueous Media. Catalytic Promiscuity or Unspecific Catalysis?

(2010) Eduardo Busto et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Chiral azo compounds: enantioselective synthesis and transformations into β-amino alcohols and α-amino acids with a quaternary stereocenter

(2010) Friedrich R. Dietz et al.   TETRAHEDRON LETTERS

Enantioselective Enzyme-Catalysed Synthesis of Cyanohydrins

(2009) Jarle Holt et al.   CURRENT ORGANIC SYNTHESIS

Hydrolase-catalyzed fast Henry reaction of nitroalkanes and aldehydes in organic media

(2009) Jun-Liang Wang et al.   JOURNAL OF BIOTECHNOLOGY

Highly efficient chemoenzymatic syntheses of trans-2-aminocyclopentanol derivatives

(2009) Javier González-Sabín et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Enzyme-catalyzed Henry (nitroaldol) reaction

(2009) Rong-Chang Tang et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Enantioselective Chemoenzymatic Synthesis oftrans-Aziridines

(2009) Bas Ritzen et al.   JOURNAL OF ORGANIC CHEMISTRY

Deracemization of Mexiletine Biocatalyzed by ω-Transaminases

(2009) Dominik Koszelewski et al.   ORGANIC LETTERS

A Multidisciplinary Approach Toward the Rapid and Preparative-Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase-/ω-Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol

(2009) Mark E. B. Smith et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

The first enantioselective synthesis of imino-deoxydigitoxose and protected imino-digitoxose by using l-threonine aldolase-catalyzed aldol condensation

(2009) Toshihiro Nishiyama et al.   TETRAHEDRON-ASYMMETRY

Stereoselectivity of an ω-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one

(2009) Kirsty Smithies et al.   TETRAHEDRON-ASYMMETRY

Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω-Transaminases

(2008) Dominik Koszelewski et al.   ADVANCED SYNTHESIS & CATALYSIS

Formal Asymmetric Biocatalytic Reductive Amination

(2008) Dominik Koszelewski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cloning and expression of the l-1-amino-2-propanol dehydrogenase gene from Rhodococcus erythropolis, and its application to double chiral compound production

(2008) M. Kataoka et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Catalytic Promiscuity of Halohydrin Dehalogenase and its Application in Enantioselective Epoxide Ring Opening

(2008) Ghannia Hasnaoui-Dijoux et al.   CHEMBIOCHEM

Synthesis of Optically Pure 2-Azido-1-arylethanols with Isolated Enzymes and Conversion to Triazole-Containing β-Blocker Analogues Employing Click Chemistry

(2008) Haribabu Ankati et al.   JOURNAL OF ORGANIC CHEMISTRY

New stereoselective synthesis of thiamphenicol and florfenicol from enantiomerically pure cyanohydrin: a chemo-enzymatic approach

(2008) Wenya Lu et al.   TETRAHEDRON

An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols

(2008) Pankaj Gupta et al.   TETRAHEDRON-ASYMMETRY

Lipase-catalysed kinetic resolution as the key step in the synthesis of a new class of optically active 5,6-trans-9,10-dihydrophenanthroline derivatives

(2008) Claudia Sanfilippo et al.   TETRAHEDRON-ASYMMETRY

Chemoenzymatic preparation of optically active anthracene derivatives

(2008) F. Javier Quijada et al.   TETRAHEDRON-ASYMMETRY

Synthesis of pharmaceutically active compounds containing a disubstituted piperidine framework

(2007) Sara Källström et al.   BIOORGANIC & MEDICINAL CHEMISTRY