Journal
TETRAHEDRON-ASYMMETRY
Volume 19, Issue 16, Pages 1898-1903Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2008.08.004
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Funding
- CSIR, New Delhi
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The expedient synthesis of enantiopure masked 1.2-amino alcohols (ee >99%) including their alkyl substituted analogues has been achieved by the regioselective ring opening of epoxides using phthalimide, followed by highly efficient kinetic resolution under mild and environmentally friendly conditions. The addition of co-solvents during kinetic resolution significantly improved the enantioselectivity with reduction in time. (C) 2008 Elsevier Ltd. All rights reserved.
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