Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1α/FNDC5/BDNF Pathway

Metabolic Reserve as a Determinant of Cognitive Aging

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The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats

(2017) Haiqin Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia

(2017) Dong-Jie Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Long-term voluntary exercise prevents post-weaning social isolation-induced cognitive impairment in rats

(2017) Nilsel Okudan et al.   NEUROSCIENCE

Can physical exercise in old age improve memory and hippocampal function?

(2016) Emrah Duzel et al.   BRAIN

DecreasedNpas4andArcmRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice

(2016) J. Qiu et al.   JOURNAL OF NEUROENDOCRINOLOGY

Associations between physical activity and cognitive functioning among middle-aged and older adults

(2016) Christina E. Miyawaki et al.   Journal of Nutrition Health & Aging

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(2016) Muaz Belviranli et al.   PHYSICIAN AND SPORTSMEDICINE

The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor

(2015) Muaz Belviranlı et al.   BEHAVIOURAL BRAIN RESEARCH

Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?

(2015) Mohammad Jodeiri Farshbaf et al.   NEUROMOLECULAR MEDICINE

Differential expression of sirtuins in the aging rat brain

(2015) Nady Braidy et al.   Frontiers in Cellular Neuroscience

Age-related learning and memory deficits in rats: role of altered brain neurotransmitters, acetylcholinesterase activity and changes in antioxidant defense system

(2014) Saida Haider et al.   AGE

Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats

(2014) Ferenc Torma et al.   BRAIN RESEARCH BULLETIN

Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus

(2014) SHENG-JUN WANG et al.   Molecular Medicine Reports

The PDE4 Inhibitor HT-0712 Improves Hippocampus-Dependent Memory in Aged Mice

(2014) Marco Peters et al.   NEUROPSYCHOPHARMACOLOGY

Curcumin improves spatial memory and decreases oxidative damage in aged female rats

(2013) Muaz Belviranlı et al.   BIOGERONTOLOGY

BDNF (I)rising from Exercise

(2013) Baoji Xu   Cell Metabolism

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Surgery-induced behavioral changes in aged rats

(2013) Iris B. Hovens et al.   EXPERIMENTAL GERONTOLOGY

Treadmill exercise induces age-related changes in aversive memory, neuroinflammatory and epigenetic processes in the rat hippocampus

(2013) Gisele Agustini Lovatel et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Exercise: Is it a neuroprotective and if so, how does it work?

(2013) Michael J. Zigmond et al.   PARKINSONISM & RELATED DISORDERS

BDNF mediates adaptive brain and body responses to energetic challenges

(2013) Krisztina Marosi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Evolutionary aspects of human exercise—Born to run purposefully

(2012) Mark P. Mattson   AGEING RESEARCH REVIEWS

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(2012) Anne Gürtler et al.   ANALYTICAL BIOCHEMISTRY

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Age and sex affect spatial and emotional behaviors in rats: The role of repeated elevated plus maze test

(2012) M. Belviranli et al.   NEUROSCIENCE

Long-term exercise treatment reduces oxidative stress in the hippocampus of aging rats

(2012) K. Marosi et al.   NEUROSCIENCE

Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

(2012) M.-S. Hashemi et al.   NEUROSCIENCE

Biogerontology: from here to where? The Lord Cohen Medal Lecture-2011

(2011) Suresh I. S. Rattan   BIOGERONTOLOGY

Exercise training increases mitochondrial biogenesis in the brain

(2011) Jennifer L. Steiner et al.   JOURNAL OF APPLIED PHYSIOLOGY

Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling

(2011) Aderbal S. Aguiar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Epigenetic regulation of the BDNF gene: implications for psychiatric disorders

(2011) F Boulle et al.   MOLECULAR PSYCHIATRY

Aerobic exercise prevents age-dependent cognitive decline and reduces anxiety-related behaviors in middle-aged and old rats

(2011) A. Pietrelli et al.   NEUROSCIENCE

Voluntary Wheel Running Reverses Age-Induced Changes in Hippocampal Gene Expression

(2011) Rachel A. Kohman et al.   PLoS One

Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume

(2010) K. I. Erickson et al.   JOURNAL OF NEUROSCIENCE

Spatial and emotional memory in aged rats: a behavioral-statistical analysis

(2010) J.A. Bergado et al.   NEUROSCIENCE

Aerobic fitness is associated with hippocampal volume in elderly humans

(2009) Kirk I. Erickson et al.   HIPPOCAMPUS

Inhibition of PI3K-Akt Signaling Blocks Exercise-Mediated Enhancement of Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus

(2009) Elodie Bruel-Jungerman et al.   PLoS One

Effects of age and anxiety on learning and memory

(2008) Ayşegül Küçük et al.   BEHAVIOURAL BRAIN RESEARCH

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols