Bexarotene attenuates early brain injury via inhibiting micoglia activation through PPARγ after experimental subarachnoid hemorrhage

Nanoformulation of dual bexarotene-tailed phospholipid conjugate with high drug loading

(2017) Ruiyu He et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Bexarotene protects against traumatic brain injury in mice partially through apolipoprotein E

(2017) Jianjun Zhong et al.   NEUROSCIENCE

Morphology, in vivo distribution and antitumor activity of bexarotene nanocrystals in lung cancer

(2016) Yongjie Wang et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Phase I/II study of the oral retinoid X receptor agonist bexarotene in Japanese patients with cutaneous T-cell lymphomas

(2016) Toshihisa Hamada et al.   JOURNAL OF DERMATOLOGY

Relaunching an old drug: the potential role of bexarotene in neurodegenerative diseases

(2016) Javier Riancho et al.   JOURNAL OF NEUROLOGY

PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats

(2016) Jerry J. Flores et al.   NEUROBIOLOGY OF DISEASE

An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage

(2016) Yue Wu et al.   NEUROSCIENCE LETTERS

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

(2016) Mikko T. Huuskonen et al.   Scientific Reports

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders

(2015) Paul D. Drew et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Rosiglitazone attenuates early brain injury after experimental subarachnoid hemorrhage in rats

(2015) Chi Gu et al.   BRAIN RESEARCH

MFGE8/Integrin β3 pathway alleviates apoptosis and inflammation in early brain injury after subarachnoid hemorrhage in rats

(2015) Fei Liu et al.   EXPERIMENTAL NEUROLOGY

Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity

(2015) A. Mounier et al.   JOURNAL OF NEUROSCIENCE

Activation of mGluR5 Attenuates Microglial Activation and Neuronal Apoptosis in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats

(2015) Zong-yong Zhang et al.   NEUROCHEMICAL RESEARCH

Activation of RXR/PPARγ underlies neuroprotection by bexarotene in ischemic stroke

(2015) Michelangelo Certo et al.   PHARMACOLOGICAL RESEARCH

Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats

(2015) Yue He et al.   STROKE

Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia

(2015) Lijuan Han et al.   STROKE

Identification of Bexarotene as a PPARγAntagonist with HDX

(2015) David P. Marciano et al.   PPAR Research

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages

(2014) B. Daniel et al.   GENES & DEVELOPMENT

The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage

(2013) Khalid A Hanafy   Journal of Neuroinflammation

Controversies and evolving new mechanisms in subarachnoid hemorrhage

(2013) Sheng Chen et al.   PROGRESS IN NEUROBIOLOGY

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms

(2008) Jae-Hyuk Yi et al.   BRAIN RESEARCH

Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists

(2007) Ramya Kapadia   Frontiers in Bioscience-Landmark