Article
Biochemistry & Molecular Biology
Bita Soltanian, Marzieh Dehghan Shasaltaneh, Gholam Hossein Riazi, Nahid Masoudian
Summary: The low dose of METH may have a protective effect in preventing and treating AD, reducing the expression of GSK3 beta, Cdk5, and PKC alpha genes in the prevention group while increasing GSK3 beta and Cdk5 in the treatment group. Additionally, it can inhibit the phosphorylated tau protein and show improvements in cell apoptosis and cell cycle in both treatment and prevention groups.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Medicine, Research & Experimental
Liting Yu, Xindong Wang, Wanheng Zhang, Eshan Khan, Chenyu Lin, Changying Guo
Summary: NM23-H1 plays a dual role in tumor metastasis, with both suppressive and promotive effects. Its versatile biochemical characteristics and the regulation by tumor cells contribute to the challenges in its clinical application for metastatic cancer therapy.
Article
Cell Biology
Shweta Kishor Sonawane, Vladimir N. Uversky, Subashchandrabose Chinnathambi
Summary: The study demonstrated the potential neuroprotective effect of Baicalein in inhibiting aggregation of human Tau protein, dissolving pre-formed fibrils, and being non-toxic to neuronal cells. Baicalein could be considered a lead molecule in combating Tau pathology in Alzheimer's disease.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Filippa Lo Cascio, Paola Marzullo, Rakez Kayed, Antonio Palumbo Piccionello
Summary: This review highlights recent research on modifying the structure of curcumin to search for new effective therapeutic agents against neurodegenerative diseases, with a particular focus on Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Vasileios Papaliagkas, Kallirhoe Kalinderi, Patroklos Vareltzis, Despoina Moraitou, Theodora Papamitsou, Maria Chatzidimitriou
Summary: Alzheimer's disease (AD) is a rapidly growing disease that urgently requires early diagnosis and treatment. Cerebrospinal fluid (CSF), which directly contacts the brain's extracellular space, is the most useful biological fluid for reflecting molecular events in the brain. Proteins and molecules that reflect the pathogenesis of AD, including neurodegeneration, accumulation of Abeta, hyperphosphorylation of tau protein, and apoptosis, can be used as biomarkers. The most commonly used CSF biomarkers for AD are total tau, phospho-tau, and Abeta42.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Batbayar Tumurbaatar, Anna Fracassi, Pietro Scaduto, Jutatip Guptarak, Randall Woltjer, Daniel Jupiter, Giulio Taglialatela
Summary: This study investigates the association of autophagy with cognitive integrity in individuals with Alzheimer's disease neuropathology but without dementia. The results suggest that preserved autophagy may protect against cognitive decline in these individuals.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Bokyung Kim, Kong-Joo Lee
Summary: Researchers have found that a small molecule called NMac1 can stabilize the protein Nm23-H1, which suppresses metastasis in breast cancer, preventing cancer cells from spreading to other tissues. This discovery may lead to the development of new anti-metastasis treatments.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Neurosciences
Longfei Li, Jin Miao, Dandan Chu, Nana Jin, Yunn Chyn Tung, Chun-Ling Dai, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Summary: Findings from this study suggest that the monoclonal tau antibody 77G7 effectively suppresses the seeding activity of AD O-tau and could potentially be developed as an immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Shuai Zhao, Ziqi Fan, Xinyi Zhang, Zheyu Li, Ting Shen, Kaicheng Li, Yaping Yan, Yunfeng Yuan, Jiali Pu, Jun Tian, Zhirong Liu, Yanxing Chen, Baorong Zhang
Summary: This study found that metformin can inhibit the propagation of tau protein in Alzheimer's disease and reduce its hyperphosphorylation. It also improves learning and memory deficits, suggesting that metformin could be a promising drug for the prevention and early treatment of AD.
Article
Biochemistry & Molecular Biology
Lei Liu, Yuqi Cai, Bianca M. Lauro, Angela L. Meunier, Jasmeer Chhatwal, Dennis J. Selkoe
Summary: This study aimed to establish a method for generating accurate calibrators as biomarkers for Alzheimer's disease. A semi-synthetic p-Tau181 calibrator was produced by coupling a recombinant tau fragment with a synthetic peptide containing a phosphorylated residue. The calibrator showed a low limit of quantification of 0.14 pg/ml when tested on multiple platforms. This simple and cost-effective method can be used to generate tau pT181 calibrators suitable for different immunoassay platforms and can be easily adapted for other phosphorylated epitopes relevant to Alzheimer's disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yanwen Wang, Miao Cai, Yue Lou, Siran Zhang, Xiaoli Liu
Summary: The study demonstrated that the upregulation of LncRNA ZBTB20-AS1 suppressed the expression of ZBTB20 and promoted the expression of GSK-3 beta and phosphorylation of Tau, thus contributing to the development of Alzheimer's disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Billie J. Matchett, Sarah J. Lincoln, Matt Baker, Nikoleta Tamvaka, Sydney A. Labuzan, Tiffany Hicks N. Sirmans, Christina M. Moloney, Jacqueline Helminger, Kelly M. Hinkle, Janisse Cabrera-Rodriguez, Daniel P. Wickland, Patrick W. Johnson, Michael G. Heckman, Joseph S. Reddy, Steven G. Younkin, Minerva M. Carrasquillo, Ranjan Duara, Neill R. Graff-Radford, Cyril Pottier, Niluefer Ertekin-Taner, Owen A. Ross, Rosa Rademakers, Dennis W. Dickson, Melissa E. Murray
Summary: We investigated the involvement of genetic variants in the SERPINA5 gene in Alzheimer's disease (AD) and found a rare missense variant (p.E228Q) that was present in a small percentage of AD cases. However, there was no significant difference in demographic or clinicopathologic characteristics between carriers and noncarriers of this variant. Moreover, our findings suggest that SERPINA5 genetic variants may not play a major role in clinicopathologic differences in AD.
Article
Clinical Neurology
Madeline S. Morrison, Hugo J. Aparicio, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, Thomas K. Karikari, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Michael A. Sugarman, Brandon Frank, Eric G. Steinberg, Katherine W. Turk, Andrew E. Budson, Rhoda Au, Lee E. Goldstein, Gyungah R. Jun, Neil W. Kowall, Ronald Killiany, Wei Qiao Qiu, Robert A. Stern, Jesse Mez, Ann C. McKee, Thor D. Stein, Michael L. Alosco
Summary: In one of the largest studies of its kind, researchers found that ante-mortem plasma phosphorylated-tau(181) concentrations can accurately differentiate brain donors with and without Alzheimer's disease. This blood test could serve as a minimally invasive and cost-effective tool for the detection and monitoring of Alzheimer's disease.
Article
Clinical Neurology
Emma M. Coomans, Jori Tomassen, Rik Ossenkoppele, Sandeep S. Golla, Marijke den Hollander, Lyduine E. Collij, Emma Weltings, Sophie M. van der Landen, Emma E. Wolters, Albert D. Windhorst, Frederik Barkhof, Eco J. C. de Geus, Philip Scheltens, Pieter Jelle Visser, Bart N. M. van Berckel, Anouk den Braber
Summary: Coomans et al. found substantial similarities in tau load and spatial distribution among identical twins, indicating a significant role of genetic factors in tau pathology. However, differences between twin pairs suggest the influence of environmental factors in tau accumulation. This study provides insights into factors associated with tau pathology and may be important for preventive strategies against Alzheimer's disease.
Article
Clinical Neurology
Alfonso Martinisi, Martin Flach, Frederik Sprenger, Stephan Frank, Markus Tolnay, David T. Winkler
Summary: The study showed that toxic tau species causing neuronal dysfunction can be cleared without inducing seeding effects, suggesting an effective therapeutic intervention in tauopathies. Moreover, recovered mice did not develop more motor impairment or tau pathology in the long term compared to control groups.
Article
Cell Biology
Yang-Ping Shentu, Yuda Huo, Xiao-Long Feng, James Gilbert, Qing Zhang, Zhen-Yu Liuyang, Xiu-Lian Wang, Guan Wang, Huan Zhou, Xiao-Chuan Wang, Jian-Zhi Wang, You-Ming Lu, Jukka Westermarck, Heng-Ye Man, Rong Liu
Article
Neurosciences
Qing Zhang, Yiyuan Xia, Yongjun Wang, Yangping Shentu, Kuan Zeng, Yacoubou A. R. Mahaman, Fang Huang, Mengjuan Wu, Dan Ke, Qun Wang, Bin Zhang, Rong Liu, Jian-Zhi Wang, Keqiang Ye, Xiaochuan Wang
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Cell Biology
Maibouge Tanko Mahamane Salissou, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Fang Huang, Yuman Wang, Zhendong Xu, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Bin Zhang, Xiaochuan Wang
Article
Clinical Neurology
Fang Huang, Minghui Wang, Rong Liu, Jian-Zhi Wang, Eric Schadt, Vahram Haroutunian, Pavel Katsel, Bin Zhang, Xiaochuan Wang
ALZHEIMERS & DEMENTIA
(2019)
Article
Clinical Neurology
Xing Li, Xiaoqin Run, Zhen Wei, Kuan Zeng, Zhihou Liang, Fang Huang, Dan Ke, Qun Wang, Jian-Zhi Wang, Rong Liu, Bin Zhang, Xiaochuan Wang
CURRENT ALZHEIMER RESEARCH
(2019)
Article
Geriatrics & Gerontology
Yang-Ping Shentu, Wen-Ting Hu, Qing Zhang, Yuda Huo, Jia-Wei Liang, Zhen-Yu Liuyang, Huan Zhou, Hui Wei, Dan Ke, Xiao-Chuan Wang, Jian-Zhi Wang, Heng-Ye Man, Jukka Westermarck, Rong Liu
NEUROBIOLOGY OF AGING
(2019)
Article
Clinical Neurology
Yang-Ping Shentu, Wen-Ting Hu, Jia-Wei Liang, Zhen-Yu Liuyang, Hui Wei, Wang Qun, Xiao-Chuan Wang, Jian-Zhi Wang, Jukka Westermarck, Rong Liu
CURRENT ALZHEIMER RESEARCH
(2019)
Article
Clinical Neurology
Hui Wei, Hui-liang Zhang, Xiao-chuan Wang, Jia-zhao Xie, Dan-dan An, Lu Wan, Jian-zhi Wang, Yi Zeng, Xi-ji Shu, Jukka Westermarck, You-ming Lu, Michael Ohlmeyer, Rong Liu
Article
Medicine, Research & Experimental
Hui Wei, Hui-liang Zhang, Jia-zhao Xie, Dong-li Meng, Xiao-chuan Wang, Dan Ke, Ji Zeng, Rong Liu
CURRENT MEDICAL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Ying Zhou, Dichen Yang, Hao Chen, Chenfei Zheng, Huanchang Jiang, Xiaoyuan Liu, Xingzhou Huang, Simin Ye, Shuangshuang Song, Nan Jiang, Zhongyuan Zhao, Shuqing Ma, Jun Ma, Kate Huang, Chaosheng Chen, Xiaofang Fan, Yongsheng Gong, Xiaochuan Wang, Junming Fan, Rong Liu, Yangping Shentu
Article
Multidisciplinary Sciences
Margaret O'Connor, Yang-Ping Shentu, Guan Wang, Wen-Ting Hu, Zhen-Dong Xu, Xiao-Chuan Wang, Rong Liu, Heng-Ye Man
Article
Biochemistry & Molecular Biology
Ying Zhou, Xiaoyuan Liu, Shuqing Ma, Nan Zhang, Dichen Yang, Ling Wang, Simin Ye, Qiongying Zhang, Jing Ruan, Jun Ma, Shiyi Wang, Nan Jiang, Zongyuan Zhao, Shujue Zhao, Chenfei Zheng, Xiaofang Fan, Yongsheng Gong, Mahaman Yacoubou Abdoul Razak, Wenting Hu, Jingye Pan, Xiaochuan Wang, Junming Fan, Jianmin Li, Rong Liu, Yangping Shentu
Summary: This study found that the activation of DNA damage-related Checkpoint kinase 1 (ChK1) in Alzheimer's disease leads to overexpression of CIP2A, which in turn causes reactive astrogliosis, neurodegeneration, and exacerbation of AD.
Article
Biochemistry & Molecular Biology
Zhang Huiliang, Yang Mengzhe, Wang Xiaochuan, Wei Hui, Du Min, Wang Mengqi, Wang Jianzhi, Chen Zhongshan, Peng Caixia, Liu Rong
Summary: High levels of zinc in AD brains induce harmful A1-type reactive astrogliosis, which promotes synaptic degeneration. Zinc activates ERK and JAK2 to phosphorylate Stat3, leading to astrogliosis.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Clinical Neurology
Wenting Hu, Zhuoqun Wang, Huiliang Zhang, Yacoubou Abdoul Razak Mahaman, Fang Huang, Dongli Meng, Ying Zhou, Shiyi Wang, Nan Jiang, Jing Xiong, Jukka Westermarck, Youming Lu, Jianzhi Wang, Xiaochuan Wang, Yangping Shentu, Rong Liu
Summary: This study reveals that DNA damage-induced Chk1 activation promotes the development of Alzheimer's disease through CIP2A-mediated tau and APP hyperphosphorylation and cognitive dysfunction, highlighting the therapeutic potential of Chk1 inhibitors in AD.
Review
Biochemistry & Molecular Biology
Hui-Liang Zhang, Xiao-Chuan Wang, Rong Liu
Summary: Zinc is crucial for human growth and development, particularly in regulating the mechanisms of neurodegenerative diseases.
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
